국제(WO) | 공개 | 출원인 : AGRICULTURE VICTORIA SERVICES PTY. LTD.;PIG RESEARCH AND DEVELOPMENT CORPORATION;CHAPPEL, Roderick, J.; | 출원번호 : AU-0000145 ( 1998-03-06 ) | 특허번호 : WO-9840099 (1998-09-17) | IPC : A61K-039/02; C12N-001/20; C12N-015/30 The present invention relates generally to novel isolated species of pathogenic bacteria and to immunoreactive molecules which are derived therefrom and their use in compositions of matter such as vaccine preparations. More particularly, the present invention is directed to a new isolated serovar of i(Leptospira) designated as serovar hurstbridge or serogroup Hurstbridge or i(L. fainei) and diagnostic assays therefor. The present invention further provides vaccines compositions which provide for the passive and active vaccination of animal subjects against i(Leptospira), in particular serovar hurstbridge or serogroup Hurstbridge or i(L. fainei).

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유럽(EP) | 공개 | 출원인 : THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; | 출원번호 : EP-0920286 ( 1996-05-17 ) | 특허번호 : EP-0837694 (1998-04-29) | IPC : A61K-039/02; C07H-021/04 The present invention presents novel leptospiral membrane lipoproteins, LipL1 and LipL2, associated with pathogenic strains of Leptospira. LipL1 is of about 35 kDa, and LipL2 is of about 41 kDa. Also disclosed are the method for purifying these proteins from Leptospira, their nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, methods for producing antibodies to these proteins, the resulting antibodies. These proteins, their immunogenic fragments, and antibodies against them, are useful for inducing an immune response to pathogenic Leptospira as well as providing a diagnostic target for leptospirosis.

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국제(WO) | 공개 | 출원인 : THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; | 출원번호 : US-0007186 ( 1996-05-17 ) | 특허번호 : WO-9636355 (1996-11-21) | IPC : A61K-039/02; C07H-021/04 The present invention presents novel leptospiral membrane lipoproteins, LipL1 and LipL2, associated with pathogenic strains of Leptospira. LipL1 is of about 35 kDa, and LipL2 is of about 41 kDa. Also disclosed are the method for purifying these proteins from Leptospira, their nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, methods for producing antibodies to these proteins, the resulting antibodies. These proteins, their immunogenic fragments, and antibodies against them, are useful for inducing an immune response to pathogenic Leptospira as well as providing a diagnostic target for leptospirosis.

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미국(US) | 등록 | 출원인 : The Regents of the University of California; | 출원번호 : US-0444646 ( 1995-05-19 ) | 특허번호 : US-5837263 (1998-11-17) | IPC : A61K-039/02; C12P-021/02; C07K-001/00 The present invention presents novel leptospiral membrane lipoproteins, LipL1 and LipL2, associated with pathogenic strains of Leptospira. LipL1 is of about 35 kDa, and LipL2 is of about 41 kDa. Also disclosed are the method for purifying these proteins from Leptospira, their nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, methods for producing antibodies to these proteins, the resulting antibodies. These proteins, their immunogenim. fragments, and antibodies against them, are useful for inducing an immune response to pathogenic Leptospira as well as providing a diagnostic target for leptospirosis. 대표청구항

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미국(US) | 등록 | 출원인 : Cornell Research Foundation, Inc.; | 출원번호 : US-0876007 ( 2015-10-06 ) | 특허번호 : US-9366671 (2016-06-14) | 등록번호 : US-9366671 (2016-06-14) | IPC : C07K-014/20(2006.01); G01N-033/569(2006.01) The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits. 대표청구항

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미국(US) | 등록 | 출원인 : Cornell Research Foundation, Inc.; | 출원번호 : US-0259782 ( 2008-10-28 ) | 특허번호 : US-8168207 (2012-05-01) | 등록번호 : US-8168207 (2012-05-01) | IPC : A61K-039/002(2006.01) The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits. 대표청구항

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미국(US) | 등록 | 출원인 : Cornell Research Foundation, Inc.; | 출원번호 : US-0534218 ( 2014-11-06 ) | 특허번호 : US-9176133 (2015-11-03) | 등록번호 : US-9176133 (2015-11-03) | IPC : G01N-033/53(2006.01); G01N-033/569(2006.01) The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits. 대표청구항

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미국(US) | 등록 | 출원인 : Cornell Research Foundation, Inc.; | 출원번호 : US-0459791 ( 2012-04-30 ) | 특허번호 : US-8900825 (2014-12-02) | 등록번호 : US-8900825 (2014-12-02) | IPC : G01N-033/554(2006.01); G01N-033/569(2006.01); C07K-014/20(2006.01); A61K-039/00(2006.01) The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits. 대표청구항

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일본(JA) | 공개 | 출원인 : INTERVET INTERNATIONAL B V; | 출원번호 : JP-0115593 ( 2017-06-13 ) | 공개번호 : JP-0200935 (2017-11-09) | IPC : A61K-039/002(2006.01); A61P-031/04(2006.01); C12P-001/04(2006.01); C12N-001/20(2006.01) PROBLEM TO BE SOLVED: To provide a method for producing a vaccine for Leptospira.SOLUTION: According to the present invention, there is provided a method for producing a vaccine for Leptospira in which the antigenic mass of a Leptospira culture is significantly increased, independent from any increase in biomass, by supplementing a Leptospira culture with one or more polyunsaturated C18 fatty acids selected from linoleic acid, α-linolenic acid, γ-linolenic acid. This provides advantages in the production Leptospira antigens, and also enables more safe and more effective production of an improved Leptospirosis vaccine.SELECTED DRAWING: None

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국제(WO) | 공개 | 출원인 : INTERVET INT BV;INTERVET INC; | 출원번호 : EP-0077590 ( 2013-12-20 ) | 공개번호 : WO-0096311 (2014-06-26) | IPC : C12N-001/20(2006.01); A61K-039/02(2006.01) The antigenic mass of Leptospira cultures can be significantly increased, independent from any increase in biomass, by supplementing Leptospira cultures with a specific type of fatty acid: a polyunsaturated C18 fatty acid. This provides advantages in the production Leptospira antigens. Also this enables the production of improved Leptospirosis vaccines, that are safer and more effective.

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