미국(US) | 공개 | 출원인 : | 출원번호 : US-0199263 ( 2002-07-18 ) | 공개번호 : US-0186340 (2003-10-02) | IPC : G01N-033/554; G01N-033/569 The epitope recognized by a mouse monoclonal antibody (MAb) to the crystalline surface layer protein (SLP) ofRickettsia typhi, SRT10, is mapped to ten amino acid residues (SRTag, TFIGAIATDT). The oligonucleotide sequence covering the epitope recognized by SRT10 is inserted to a mammalian expression vector together with multiple cloning sites. When the SRTag is fused in frame to the coding region of protein gene and expressed in bacteria or mammalian cells, the MAb SRT10 can detect the tagged protein by immunoblotting, immunocytochemistry, and immunoprecipitation. 대표청구항

원문보기 초록 연관자료탐색

미국(US) | 등록 | 출원인 : The United States of America as represented by the Secretary of the Navy; | 출원번호 : US-0169927 ( 1993-12-20 ) | 특허번호 : US-5783441 (1998-07-21) | IPC : C12N-015/00; C12N-001/20; A61K-039/00; C07H-021/02 All or part of the DNA sequence of the gene which encodes the S-layer protein of R. prowazekii as illustrated in Sequence ID No. 1 as well as a truncated identical piece of this gene in R. typhi as well as the 5' and 3' noncoding regions can be used for vaccination against typhus and spotted fever rickettsial infection or to diagnose the diseases caused by these bacteria. The invention is also accomplished by the deduced amino acid sequence of the S-layer protein of R. prowazekii derived from the DNA sequence of the encoding gene. Further, the invention includes the peptide or protein products based on all or parts of this gene. 대표청구항

원문보기 초록 연관자료탐색

국제(WO) | 공개 | 출원인 : THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY; | 출원번호 : US-0009376 ( 2007-04-18 ) | 공개번호 : WO-7123906 (2007-11-01) | IPC : A61K-039/02; A61P-031/04; G01N-033/53; G01N-033/543 The invention relates to the construction of recombinant, immunodominant Rickettsia typhi proteins. The invention also relates to a method for the use of the recombinant proteins, either singly or in combination, in detection and diagnostic assays. The proteins can also be used in anti-Rickettsia typhi immunogenic formulations.

원문보기 초록 연관자료탐색

미국(US) | 공개 | 출원인 : | 출원번호 : US-0454038 ( 2009-04-27 ) | 공개번호 : US-0311088 (2010-12-09) | IPC : G01N-033/53(2006.01); C07K-014/29(2006.01); A61K-039/02(2006.01); A61P-031/04(2006.01); A61K-031/00(2006.01) The invention relates to the construction of recombinant, immunodominant Rickettsia typhi proteins. The invention also relates to a method for the use of the recombinant proteins, either singly or in combination, in detection and diagnostic assays. The proteins can also be used in anti-Rickettsia typhi immunogenic formulations. 대표청구항

원문보기 초록 연관자료탐색

미국(US) | 공개 | 출원인 : Ching,Wei Mei; | 출원번호 : US-0789122 ( 2007-04-18 ) | 공개번호 : US-0298047 (2007-12-27) | IPC : A61K-039/02(20060101); A61P-031/04(20060101); A61P-031/00(20060101); G01N-033/53(20060101); G01N-033/543(20060101) The invention relates to the construction of recombinant, immunodominant Rickettsia typhi proteins. The invention also relates to a method for the use of the recombinant proteins, either singly or in combination, in detection and diagnostic assays. The proteins can also be used in anti-Rickettsia typhi immunogenic formulations. 대표청구항

원문보기 초록 연관자료탐색

미국(US) | 등록 | 출원인 : The United States of America as represented by the Secretary of the Navy; | 출원번호 : US-0454038 ( 2009-04-27 ) | 특허번호 : US-8012699 (2011-09-06) | 등록번호 : US8012699 (2011-08-23) | IPC : G01N-033/53(2006.01) The invention relates to the construction of recombinant, immunodominant Rickettsia typhi proteins. The invention also relates to a method for the use of the recombinant proteins, either singly or in combination, in detection and diagnostic assays. The proteins can also be used in anti-Rickettsia typhi immunogenic formulations. 대표청구항

원문보기 초록 연관자료탐색

미국(US) | 등록 | 출원인 : The United States of America as represented by the Secretary of the Navy; | 출원번호 : UP-0789122 ( 2007-04-18 ) | 특허번호 : US-7544778 (2009-06-09) | 등록번호 : US-7544778 (2009-07-01) | IPC : C07K-014/00(2006.01) The invention relates to the construction of recombinant, immunodominant Rickettsia typhi proteins. The invention also relates to a method for the use of the recombinant proteins, either singly or in combination, in detection and diagnostic assays. The proteins can also be used in anti-Rickettsia typhi immunogenic formulations. 대표청구항

원문보기 초록 연관자료탐색

미국(US) | 공개 | 출원인 : | 출원번호 : US-0047899 ( 2011-03-15 ) | 공개번호 : US-0171245 (2011-07-14) | IPC : A61K-039/02(2006.01) The invention relates to a recombinant immunogenic composition from Rickettsia typhi. The invention also relates to a method for the use of the recombinant proteins in detection and diagnostic assays and as a component in formulations for the induction of an anti-R. typhi immune response. 대표청구항

원문보기 초록 연관자료탐색

미국(US) | 공개 | 출원인 : United States of America as Represented by the Secretary of the Navy; | 출원번호 : US-0881498 ( 2007-07-27 ) | 공개번호 : US-0022754 (2009-01-22) | IPC : A61K-039/02(20060101); C07K-014/29(20060101); C07K-014/195(20060101); A61P-031/04(20060101); A61P-031/00(20060101); G01N-033/569(20060101) The invention relates to a recombinant immunogenic composition from Rickettsia typhi. The invention also relates to a method for the use of the recombinant proteins in detection and diagnostic assays and as a component in formulations for the induction of an anti-R. typhi immune response. 대표청구항

원문보기 초록 연관자료탐색

미국(US) | 등록 | 출원인 : The United States of America as represented by the Secretary of the Navy; | 출원번호 : US-0047899 ( 2011-03-15 ) | 특허번호 : US-8900818 (2014-12-02) | 등록번호 : US-8900818 (2014-12-02) | IPC : G01N-033/53(2006.01); G01N-033/554(2006.01); A61K-039/02(2006.01); G01N-033/569(2006.01) The invention relates to a recombinant immunogenic composition from Rickettsia typhi. The invention also relates to a method for the use of the recombinant proteins in detection and diagnostic assays and as a component in formulations for the induction of an anti-R. typhi immune response. 대표청구항

원문보기 초록 연관자료탐색