The purpose of this study is to predict factors on leave planning of nurses working in medium-sized hospital. Subjects were 381 nurses working in 4 medium-sized hospitals in the metropolitan area (less than 300 beds), located in I city and P city. Empirical data was collected from a self-administered survey using a structured questionnaire including general characteristics, practice environment perception, job satisfaction, turnover intention, leave planning (yes or no). The data were analyzed using logistic regression with the SPSS WIN 20.0 program. There were significant differences in leave planning depending on general characteristics (age, marital status, grade in nursing management fee). Major reasons of leave planning are ‘low salary’ and ‘heavy workload’. Predictive factors on leave planning of subjects were marital status (married) (OR: 0.386, 95% CI: 0.181-0.820), practice environment perception in nursing (OR: 3.822, 95% CI: 1.325-11.022), job satisfaction (OR: 7.627, 95% CI: 2.570-22.633), turnover intention (OR: 0.110, 95% CI: 0.060-0.203). Thus, it is needed to improve practice environment in nursing and job satisfaction, and to increase a monthly salary for decreasing leave planning among nurse working in medium-sized hospital.