The purpose of this study is to establish an ACT group counseling program for the improvement of the quality of life of women with infertility and those with subfertility and to validate its effects. I designed this program to improve the women’s quality of life by identifying their characteristics and organizing ACT's main treatment mechanisms (acceptance, decentering [cognitive defusion], and a value-centered life). The participants were women with infertility between 30 and 50 years of age who had been married over a year but had never had a child. A total of 21 participants were selected; 11 were randomly assigned to the experimental group and 10 to the control group. For the experimental group, the ACT program was performed once a week for 150 minutes for 8 weeks. The experimental group and control group participated in pre-post questionnaires to analyze the program’s effects. The Fertility Problem Inventory (FPI), Experience Questionnaire (EQ), and Fertility Quality of Life Questionnaire (FertiQoL) were used as research tools. To analyze effect validation, I used covariance analysis (ANCOVA), where the pre-score was the covariate variable, in order to control the influence of the pre-score on post-mortem, and analyzed the content of the activities and experience reports by period. The results of this study were as follows: FPI, EQ, and FertiQoL were significantly influenced in the experimental group, and this program has proven to be effective in improving the quality of life of women with infertility. In addition, we also reported on the experience of helping to shape the spouse’s self-awareness and acceptance through the change of perception in the sub-domain of the quality of life, and consequently to develop intimacy in the couple.