Lysosomes are structurally and chemically spherical vesicles containing hydrolytic enzymes, which are capable of breaking down actually all kinds of organic molecules. Transportation of lysosomal enzymes into the lysosomes depends on the phosphorylation of their chains and the binding of the phospho...
Lysosomes are structurally and chemically spherical vesicles containing hydrolytic enzymes, which are capable of breaking down actually all kinds of organic molecules. Transportation of lysosomal enzymes into the lysosomes depends on the phosphorylation of their chains and the binding of the phosphorylated residues to M6P receptors. The M6P recognition marker is generated in a two-step enzyme reaction. One of them phosphodiesterase(PDEs) on the activity of phosphorylation of mannose residues can be determined in vitro (Radons et al 1994). PDEs play a important role in regulation of activation of lysosomes. Corynebacterium glutamicum is a small, non-pathogenic, non-moving Gram-positive soil bacterium. it has particular importance in biotechnology. In this study, the main object is to control the function of lysosome by regulating the phosphodiesterase 4(PDE 4). Also, it tried to find out efficacy of C. glutamicum in decomposition process of carcass and whether it can be what action lysosomes to microbial contamination generated from the decay of livestock. It was observed that lysosomes were inhibited by rolipram and transfection. PDE4 series of protein expression was reduced in high concentration of rolipram. But result of transfection, protein expression was confirmed to be reduced. Lysosome was activated at low concentrations, lysosome was suppressed at high concentrations by rolipram had to deal with high concentration that emerges original function. The anticancer activity of rolipram concentration was shown in lysosomal enzyme treated with rolipram of low concentration. Reason for the anticancer activity was confirmed through the cathepsin B and D assay. In fluorescence intensity treated antisense on the PDE4 A, B, C, and D was decreased activity of lysosomes and ROS. A result that was up to anticancer activity, lysosome treated antisense on PDE4B, C and D has decreased anticancer activity. These results showed the PDE4 series are conjunctly related with lysosomal activity. Condition of C. glutamicum is activated, regardless both anaerobic and aerobic conditions, soil exists and, to be close to the optimum conditions as possible temperatures, moisture content is about 1/10 of the culture. Circumference changes, the bloated stage gradually occur in containers not processing C. glutamicum but, it found that bloated stage happened rapidly to 30 days, entering skeleton based from 40 days in containers processing C. glutamicum. Using the C. glutamicum is rapidly decaying bodies, processing the carcass was found to be that treated the lysosomes can remove toxic microorganisms adversely affecting the environment. Therefore, C. glutamicum which is soil microorganism strain was trying to accelerate the decay of the carcass. Further, we tried to find a way to purify the soil contamination is caused by decomposition of livestock. In conclusion, PDE4 has been found to be an enzyme capable of modulating the activity of the lysosome. Also, we were desired to solve microbial contamination from burial through the lysosome and accelerate carcass decomposition.
Lysosomes are structurally and chemically spherical vesicles containing hydrolytic enzymes, which are capable of breaking down actually all kinds of organic molecules. Transportation of lysosomal enzymes into the lysosomes depends on the phosphorylation of their chains and the binding of the phosphorylated residues to M6P receptors. The M6P recognition marker is generated in a two-step enzyme reaction. One of them phosphodiesterase(PDEs) on the activity of phosphorylation of mannose residues can be determined in vitro (Radons et al 1994). PDEs play a important role in regulation of activation of lysosomes. Corynebacterium glutamicum is a small, non-pathogenic, non-moving Gram-positive soil bacterium. it has particular importance in biotechnology. In this study, the main object is to control the function of lysosome by regulating the phosphodiesterase 4(PDE 4). Also, it tried to find out efficacy of C. glutamicum in decomposition process of carcass and whether it can be what action lysosomes to microbial contamination generated from the decay of livestock. It was observed that lysosomes were inhibited by rolipram and transfection. PDE4 series of protein expression was reduced in high concentration of rolipram. But result of transfection, protein expression was confirmed to be reduced. Lysosome was activated at low concentrations, lysosome was suppressed at high concentrations by rolipram had to deal with high concentration that emerges original function. The anticancer activity of rolipram concentration was shown in lysosomal enzyme treated with rolipram of low concentration. Reason for the anticancer activity was confirmed through the cathepsin B and D assay. In fluorescence intensity treated antisense on the PDE4 A, B, C, and D was decreased activity of lysosomes and ROS. A result that was up to anticancer activity, lysosome treated antisense on PDE4B, C and D has decreased anticancer activity. These results showed the PDE4 series are conjunctly related with lysosomal activity. Condition of C. glutamicum is activated, regardless both anaerobic and aerobic conditions, soil exists and, to be close to the optimum conditions as possible temperatures, moisture content is about 1/10 of the culture. Circumference changes, the bloated stage gradually occur in containers not processing C. glutamicum but, it found that bloated stage happened rapidly to 30 days, entering skeleton based from 40 days in containers processing C. glutamicum. Using the C. glutamicum is rapidly decaying bodies, processing the carcass was found to be that treated the lysosomes can remove toxic microorganisms adversely affecting the environment. Therefore, C. glutamicum which is soil microorganism strain was trying to accelerate the decay of the carcass. Further, we tried to find a way to purify the soil contamination is caused by decomposition of livestock. In conclusion, PDE4 has been found to be an enzyme capable of modulating the activity of the lysosome. Also, we were desired to solve microbial contamination from burial through the lysosome and accelerate carcass decomposition.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.