Sleep is essential for homeostatic function as well as neuronal plasticity. Reduced sleep time and quality, which is easily influenced by socioeconomic factors, lifestyle factors, stress, and age, are common in modern society. Sleep deprivation depresses cellular function, which unavoidably leads to...
Sleep is essential for homeostatic function as well as neuronal plasticity. Reduced sleep time and quality, which is easily influenced by socioeconomic factors, lifestyle factors, stress, and age, are common in modern society. Sleep deprivation depresses cellular function, which unavoidably leads to a variety of neurobiological, physiological, metabolic, and cognitive deficiencies. Based on the trends of sleep time and insomnia-related symptoms, the demand to improve sleep deprivation and its side effects is increasing.
To investigate a natural plants that have an anti-stress effect on sleep deprivation, chapter I describes the anti-stress effects of Rosa rugosa Thunb. (family Rosaceae) on sleep deprived rats in vivo and H2O2 or corticosterone-induced cells in vitro. Sleep deprivation impairs not only physiological (survival, body weight, and drowsiness scores) but also behavioral activities, including cognitive dysfunction. It was significantly recovered by the treatment of R. rugosa distilled water extracts administrated orally in a concentration dependent manner. H2O2 (100 μM) or corticosterone (1 mM)-induced cell death was also significantly prevented by the pretreatment of RO extract. The neuroprotective effect against sleep deprivation and H2O2 or corticosterone was performed as an antagonist of the 5-HT6 receptor by inhibiting cyclic AMP activity. Also, activation of ERK 1/2 and MEK induced by a 5-HT6 receptor were inhibited by R. rugosa extract. Column fractions of RO eluted by water:methanol in HP-20 resins were performed to identify the active components contained in the R. rugosa extract. The 50% and, 80% MeOH fractions showed a strong inhibition effect of cAMP. In conclusion, R. rugosa has effective and potential benefits for anti-stress regarding stress induced by sleep deprivation due to the 5-HT6 antagonist that inhibits cAMP.
The anti-stress effects of Punica granatum L. (family Lythraceae) and Citrus junos sieb ex Tanaka (family Rutaceae) on cell and sleep-deprived rats are discussed in chapter II. The P. granatum and C. junos extracts showed a neuroprotective effect in H2O2/corticosterone-induced SH-SY5Y cells. The P. granatum recovered impairments of physiological (survivals, body weight, and drowsiness score) and, behavioral (rotarod, passive avoidance, hot hyperalgesia, and Y maze) parameters as well as biochemical factors (cortisol, serotonin, dopamine, testosterone, and IGF-1 contents in serum) induced by sleep deprivation. The C. junos extract had a weak efficacy for sleep deprivation-induced impairments, however, it was significantly recovered by the treatment of the P. granatum distilled water extracts administrated orally in dependent concentration . In addition, the P. granatum extract improved chronic sleep deprivation-induced reduction in the brain's GSH, catalase, and SOD. In conclusion, sleep deprivation induces impairments of body functions, and P. granatum prevents these impairments, likely through its antioxidant activity in the brain.
Therefore, these findings suggest that R. rugosa, P. granatum, and C. junos have neuroprotective effects against H2O2 and corticosterone-induced stress in vitro, and R. rugosa and P. granatum have strong protective effects against sleep deprivation-induced stress in vivo.
Sleep is essential for homeostatic function as well as neuronal plasticity. Reduced sleep time and quality, which is easily influenced by socioeconomic factors, lifestyle factors, stress, and age, are common in modern society. Sleep deprivation depresses cellular function, which unavoidably leads to a variety of neurobiological, physiological, metabolic, and cognitive deficiencies. Based on the trends of sleep time and insomnia-related symptoms, the demand to improve sleep deprivation and its side effects is increasing.
To investigate a natural plants that have an anti-stress effect on sleep deprivation, chapter I describes the anti-stress effects of Rosa rugosa Thunb. (family Rosaceae) on sleep deprived rats in vivo and H2O2 or corticosterone-induced cells in vitro. Sleep deprivation impairs not only physiological (survival, body weight, and drowsiness scores) but also behavioral activities, including cognitive dysfunction. It was significantly recovered by the treatment of R. rugosa distilled water extracts administrated orally in a concentration dependent manner. H2O2 (100 μM) or corticosterone (1 mM)-induced cell death was also significantly prevented by the pretreatment of RO extract. The neuroprotective effect against sleep deprivation and H2O2 or corticosterone was performed as an antagonist of the 5-HT6 receptor by inhibiting cyclic AMP activity. Also, activation of ERK 1/2 and MEK induced by a 5-HT6 receptor were inhibited by R. rugosa extract. Column fractions of RO eluted by water:methanol in HP-20 resins were performed to identify the active components contained in the R. rugosa extract. The 50% and, 80% MeOH fractions showed a strong inhibition effect of cAMP. In conclusion, R. rugosa has effective and potential benefits for anti-stress regarding stress induced by sleep deprivation due to the 5-HT6 antagonist that inhibits cAMP.
The anti-stress effects of Punica granatum L. (family Lythraceae) and Citrus junos sieb ex Tanaka (family Rutaceae) on cell and sleep-deprived rats are discussed in chapter II. The P. granatum and C. junos extracts showed a neuroprotective effect in H2O2/corticosterone-induced SH-SY5Y cells. The P. granatum recovered impairments of physiological (survivals, body weight, and drowsiness score) and, behavioral (rotarod, passive avoidance, hot hyperalgesia, and Y maze) parameters as well as biochemical factors (cortisol, serotonin, dopamine, testosterone, and IGF-1 contents in serum) induced by sleep deprivation. The C. junos extract had a weak efficacy for sleep deprivation-induced impairments, however, it was significantly recovered by the treatment of the P. granatum distilled water extracts administrated orally in dependent concentration . In addition, the P. granatum extract improved chronic sleep deprivation-induced reduction in the brain's GSH, catalase, and SOD. In conclusion, sleep deprivation induces impairments of body functions, and P. granatum prevents these impairments, likely through its antioxidant activity in the brain.
Therefore, these findings suggest that R. rugosa, P. granatum, and C. junos have neuroprotective effects against H2O2 and corticosterone-induced stress in vitro, and R. rugosa and P. granatum have strong protective effects against sleep deprivation-induced stress in vivo.
주제어
#Anti-stress sleep deprivation Rosa rugosa Punica granatum Citrus junos
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