Abstract ▼ AI-Helper

The purpose of this study was to investigate the effect of Fermented extract of Artemisiae Iwayomogii Herba, Curcumae Longae, Crataegi Fructus and Salvia miltiorrhiza Bunge(FMH) on Anti-inflammation associated with Dyslipidemia and Anti-oxidation in RAW264.7 and HUVEC Cell.
at first, total poly...

The purpose of this study was to investigate the effect of Fermented extract of Artemisiae Iwayomogii Herba, Curcumae Longae, Crataegi Fructus and Salvia miltiorrhiza Bunge(FMH) on Anti-inflammation associated with Dyslipidemia and Anti-oxidation in RAW264.7 and HUVEC Cell.
at first, total polyphenol, total flavonoids, DPPH radical scavenging activity, ABTS radical scavenging activity and safety in cytotoxicity of FMH were measured. after treatment with FMH in RAW264.7 cell, production of NO, cytokines, LTB4 were measured and after treatment with FMH in HUVEC cell, production of cDNA of genes related to inflammation were measured.

The result were summarized as follows :
1. FMH contained polyphenol and flavonoids. and DPPH and ABTS radical scavenging activity increased in FMH in a concentration-dependent manner.
2. FMH showed inhibitory effect on nitric oxide(NO), cytokines and LTB4 in RAW264.7 cell compared to control group.
3. FMH decreased transcription of pro-inflammatory genes, whereas increased transcription of anti-inflammatory genes in HUVEC cell.

These results suggest that FMH is effective in antioxidation and treatment and prevention of dyslipidemia, atherosclerosis, ischemic heart disease, stroke and other cardiocerebrovascular disease.

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