정신지체와 인체내 카드뮴 함량과의 관련성을 보기 위해 정신지체아 297명(가정이 있는 아동이 다니는 특수학교 1개교의 132명과 고아로 구성된 특수학교 1개교의 165명)을 대상으로 두발중 카드뮴 및 아연함량을 측정하였으며 학업성적이 중위권 이상인 일반 국민학교 학생 117명을 대조군으로 하여 비교해 보았다. 시료의 분석은 원자흡광광도계를 이용하였다. 두발 중 카드뮴 함량의 연령에 따른 차이는 없었으며 아연은 대조군 남자의 경우 연령 증가에 비례하였다. 가정이 있는 정신지체아의 경우 카드뮴 함량이 남녀 각각
The relationship between cadmium level and mental retardation was investigated. The 297 subjects with mental retardation were drawn from two schools providing special educational services, one, consisted of children living in an orphan home, another, children with parents. The 117 control subjects were drawn from whom had got average or above average academic achivement in a general elementary school. Hair sample was taken from the nape of the neck and the cadmium and zinc analysis were carried out on an atomic absorption spectrophotometer (IL 551). Children in the retarded group had significantly higher cadmium levels compared with control but not in zinc levels. There was no relationship between metal concentrations and age except control male group, which showed significant positive linear relationship in zinc, and there was no difference between sex in both metal except the male orphan group in cadmium. In the orphan group, there was relationship between severity of retardation and cadmium concentration in both sex but not in retarded children with parents. No difference in cadmium levels between the group with Down's syndrome, one of causes of mental retardation, and the control group suggested the cadmium as a possible cause of mental retardation. In the case of accompanying autism, zinc level was significantly lower than that of other accompanying diseases. Although not establishing an etiologic relationship, findings of this study suggest that there are some influeces of cadmium on mental retardation, and call for a continuing study.
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