수은($HgCl_2$) 중독 흰쥐에서 마늘즙의 antidotic effect를 검토하기 위한 4주간 실험에서 흰쥐 체중 kg당 주 1회 수은을 2.5mg 투여하고 아울러 마늘즙을 매일 식이의 2%를 투여한 흰주의 성장율이 수은만을 투여한 흰주 보다 약 30% 증가(개선)되었다. 마늘즙 단독 투여군은 오히려 대조군 보다 상장율이 15% 증가되어 마늘이 일반 tonic 효과를 나타냈다. 혈액검사에서 수은 투여군(M)은 GPT, GOT 상승과 cholesterol, triglyceride, Alk.p의 병적 감소를 보이고, 무기수은 중독 표기 기관인 신장에 대한 그의 기능검사 지표항목인 BUN과 uric산 creatinine의 측정값들이 수은 투여로 상승했으나 마늘즙을 투여(MG군)하여 이들 측정값이 유의적으로 감소하였다. 혈액과 신장의 수은 함량 조사에서 대조군(0.015, 0.02ppm)과 비교한 수은만 투여군이 각각 0.46, 0.51ppm로 높으나 수은과 함께 마늘즙 투여군은 각각 0.3, 0.33ppm으로 유의적인 감소를 보였다. 따라서 마늘즙의 non protein sulfur amino acid가 수은에 대하여 antidotic effect을 갖는 것으로 관찰되었다.
수은($HgCl_2$) 중독 흰쥐에서 마늘즙의 antidotic effect를 검토하기 위한 4주간 실험에서 흰쥐 체중 kg당 주 1회 수은을 2.5mg 투여하고 아울러 마늘즙을 매일 식이의 2%를 투여한 흰주의 성장율이 수은만을 투여한 흰주 보다 약 30% 증가(개선)되었다. 마늘즙 단독 투여군은 오히려 대조군 보다 상장율이 15% 증가되어 마늘이 일반 tonic 효과를 나타냈다. 혈액검사에서 수은 투여군(M)은 GPT, GOT 상승과 cholesterol, triglyceride, Alk.p의 병적 감소를 보이고, 무기수은 중독 표기 기관인 신장에 대한 그의 기능검사 지표항목인 BUN과 uric산 creatinine의 측정값들이 수은 투여로 상승했으나 마늘즙을 투여(MG군)하여 이들 측정값이 유의적으로 감소하였다. 혈액과 신장의 수은 함량 조사에서 대조군(0.015, 0.02ppm)과 비교한 수은만 투여군이 각각 0.46, 0.51ppm로 높으나 수은과 함께 마늘즙 투여군은 각각 0.3, 0.33ppm으로 유의적인 감소를 보였다. 따라서 마늘즙의 non protein sulfur amino acid가 수은에 대하여 antidotic effect을 갖는 것으로 관찰되었다.
It was attempted to observe the antidotic effects of garlic on mercury intoxicated rat model in vivo. The experimental model group consists of garlic juice treated group (G), garlic juice-mercury treated group(MG), mercury treated group (M), and control group (basal diet), The garlic juice of 2% to ...
It was attempted to observe the antidotic effects of garlic on mercury intoxicated rat model in vivo. The experimental model group consists of garlic juice treated group (G), garlic juice-mercury treated group(MG), mercury treated group (M), and control group (basal diet), The garlic juice of 2% to the daily diet by weight was administered orally to G and MG groups, The single dose of 2.5mgHG/Kg per week was given orally to M and MG groups. the study was carried out for 4 weeks. The results of experiment were as follows. For the group of Mg, and the weight increasing rate was improved to about 30% compared to that of group M. Furthermore a general tonic efficay of garlic was observed in G group in term of increased weight gain rate (bout 15%) than control. In the biochemical studies of rat blood garlic showed effects on lowering the abnormally elevated GPT, GOT, uric acid creatinine value, and especially in lowering the BUN value of Hg treated rat that was selectively elevated in the case of impared renal function such as acute gromerulonephritis caused by Hg intoxication. In the analytical studies blood and renal Hg contents. HG group showed lower value (0.3, 0.33ppm) than that of M group (0.46, 0.51 ppm) Significant difference in reducing Hg level due to the antidotic effect of garlic was observed. In conclusion, it was revealed out from this research, the main principles of garlic, nonprotein sulfur amino acid (alliin) and sulfur compounds (allicin and diallyl disulfides) seem to almost certainly have an antidotic effect on mercury intoxication of rat in vivo.
It was attempted to observe the antidotic effects of garlic on mercury intoxicated rat model in vivo. The experimental model group consists of garlic juice treated group (G), garlic juice-mercury treated group(MG), mercury treated group (M), and control group (basal diet), The garlic juice of 2% to the daily diet by weight was administered orally to G and MG groups, The single dose of 2.5mgHG/Kg per week was given orally to M and MG groups. the study was carried out for 4 weeks. The results of experiment were as follows. For the group of Mg, and the weight increasing rate was improved to about 30% compared to that of group M. Furthermore a general tonic efficay of garlic was observed in G group in term of increased weight gain rate (bout 15%) than control. In the biochemical studies of rat blood garlic showed effects on lowering the abnormally elevated GPT, GOT, uric acid creatinine value, and especially in lowering the BUN value of Hg treated rat that was selectively elevated in the case of impared renal function such as acute gromerulonephritis caused by Hg intoxication. In the analytical studies blood and renal Hg contents. HG group showed lower value (0.3, 0.33ppm) than that of M group (0.46, 0.51 ppm) Significant difference in reducing Hg level due to the antidotic effect of garlic was observed. In conclusion, it was revealed out from this research, the main principles of garlic, nonprotein sulfur amino acid (alliin) and sulfur compounds (allicin and diallyl disulfides) seem to almost certainly have an antidotic effect on mercury intoxication of rat in vivo.
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