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논문 상세정보

Elfvingia applanata 엑스의 항균력 및 Naringenin과의 병용효과

Antimicrobial Activity of Elfvingia applanata Extract Alone and in Combination with Naringenin

초록

담자균류의 하나인 잔나비걸상 자실체로부터 얻은 수성엑스의 항세균 시험과 항진균 시험을 액체배지 희석법으로 실시하고 naringenin과의 병용시험을 checkerboard assay 법으로 평가하였다. 항세균 시험결과 전반적으로 그람음성균보다 그람양성균에 대해 비교적 양호한 항균력을 나타내었으나 사용된 균주중 그람음성균인 Proteus vulgaris 78615는 MIC가 1.125 mg/ml로 가장 양호한 항균효과를 나타내었다. 11종의 균주에 대해 실시된 항진균 시험결과 Candida albicans, Fusarium spp. 그리고 Trichophyton mentagraphytes의 MIC가 7.5 mg/ml로 다른 균주에 대한 항진균 효과보다 두배 더 강한 효과를 나타내었다. naringenin과의 병용시험에서 Staphylococcus aureus ATCC 25923에 대하여 부분적 상승효과를 나타내었고, Klebsiella pneumoniae ATCC 10031과 Salmonella typhi ATCC 6229 두 균주에서 상가효과가 관찰되었다. 그리고 Bacillus subtilis ATCC 6633을 비롯한 7종의 균주에서 무관효과를 나타내었으며 길항효과는 관찰되지 않았다.

Abstract

As part of our search for less toxic antimicrobial agents from natural resources, the antimicrobial activity of Elfvingia applanata $(P_{ers.})\;K_{arst.}$ extract was examined alone and in combination with naringenin. EA, the aqueous extract from the carpophores of E. applanata, was lyophilized and a dark brownish powder was obtained. Antimicrobial activity of EA was tested in vitro against nineteen strains of bacteria and eleven strains of fungi by serial broth dilution method, and expressed by minimal inhibitory concentration (MIC). Among nineteen strains of bacteria tested, the antimicrobial activity of EA was the most potent against Proteus vulgaris showing MIC of 1.125 mg/ml. EA also inhibited the growth of the selected fungi at higher concentrations ranging from 7.5 mg/ml to 15.0 mg/ml. To investigate the effect of antimicrobial combinations of EA with naringenin, the fractional inhibitory concentration index (FICI) was determined by checkerboard assay for each strain. The antimicrobial combinations of EA with naringenin resulted in partial synergism against Staphylococcus aureus only, and showed additive effect in two strains including Klebsiella pneumoniae and Salmonella typhi. Antagonism was not found.

참고문헌 (34)

  1. Antibiotics from Basidiomycetes. 26, Phlebiakauranol aldehydean antifungal and cytotoxic metabolite from Punctularia alropurpurascens , Anke, H.;Casser, I.;Steglich, W. , J. Antibiotics / v.40,pp.443-449, 1986
  2. Antibiotics from basidiomycetes. X. Scorodonin, a new antibacterial and antifungal metabolite from Marrassmius scorodonius (FR.) , Anke, T.;Kupa, J.;Schramm, G.;Steglich, W. , FR. J. antibiotics / v.33,pp.463-467, 1980
  3. Prosthetic valve endocarditis by Staphylococcus epidermidis. Development of rifampin resistance during vancomycin and rifampin therapy , Chamovitz, B.;Bryant, R.E.;Gibert, D.N.;Harstein, A.I. , J.A.M.A. / v.253,pp.2867-2868, 1985
  4. Studies on the constituents of the Higher Fungi of Korea (IV). An antibiotic component and a sterol of Coriolus sanguineus Fr. , Chung, K.S.;Shim, M.J.;Kim, B.K. , Arch. Pharm. Res. / v.10,pp.33, 1978
  5. Antibacterial sesquiterpene arylester from Armillaria mellea , Donelly, D.;Abe, F.;Conveney, D.;Fukuda, N.;O'Reilly, J. , J. Natural Product. / v.48,pp.10-16, 1985
  6. Antagonists of nucleic acid derivatives VIII. synergism in combination of biochemicaloly related metabolites , Elion, G.B.;Singer, S.;Hitchings, G.H. , J. Biol. Chem. / v.,pp.477-488, 1954
  7. Acta Pathol. et Microbiol , Ericsson, H.;Sherris, J.C. , / v.,pp., 1971
  8. Mycology for the clinical Laboratory , Gary, S.M.;Douglas, M.J. , / v.,pp.262-266, 1979
  9. Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method , Hallander, H.O.;Dornbusch, L.;Gezelius, L.;Jacobson, K.;Karlsson, I. , Agents Chemother / v.22,pp.743-752, 1982
  10. Studies on inorganic constituents and antimicrobial activity of Elfvingia applanata (Per) $K_{ARST}$ in Korea , Han, S.S.;Baik, S.R. , Chungbuk J. Pharm. Sci. / v.3,pp.44-50, 1988
  11. Invitro interactions between fifampin and ampicillin or chloramphenicol against haemophilus influenzae , Jadavji, T.;Prober, C.G.;Cheung, R. , Agents Chemother / v.26,pp.91-93, 1984
  12. The combined action of penicillin with streptomycin or chloromycetin on Enterococci in vitro , Jawetz, E.;Gunnison, J.B.;Colman, V.R. , Science / v.111,pp.254, 1950
  13. Fungal nucleic acids as interferon inducers , Kandefer, S.M.;Kawecki, Z.;Guz, M. , Acta. Microbiol. Pol. / v.28,pp.277-291, 1979
  14. A pictorial book of the Korean mushroom , Kim, S.S.;Kim, Y.B. , / v.,pp.298-299, 1990
  15. Moxa compositions containing germanium , Kondo, A.;Kondo, K. , / v.,pp., 1987
  16. Antimicrobial combinations;Antibiotics in Laboratory Medicine , Krogsted, D.J.;Moellering, R.C.;Lorian, V.(ed.) , / v.,pp.537-595, 1986
  17. Illustrated flora and fauna of Korea, 28(Mushroom) , Lee, J.Y.;Hong, S.W. , / v.,pp.366-367, 1983
  18. Studies on the antibacterial activity of Poria cocos , Lee, K.S.;Lee, M.W.;Lee, J.Y. , Kor. J. Mycol. / v.10,pp.27-31, 1982
  19. Therapy for experimental intraabdominal sepsis: Comparison of four cephalosprins with clindamycin plus gentamycin , Louie, T.J.;Onderdonk, A.B.;Gorbach, S.L.;Bartlett, J.G. , J. Infect. Dis. / v.135,pp., 1977
  20. Manufactures of a new ${\beta}-glucan$ , Misaki, A.;Sone, Y.;Yoshida, M.;Takeuchi, K. , / v.,pp., 1985
  21. Studies on the host-mediated antitumor polysaccharides. VI. Isolation and characterization of antitumor active ${\beta}-D-glucan $ from mycelial cells fo Ganoderma applanatum , Mizuno, T.;Ushiyama, M.;Usui, T.;Arakawa, M.;Shinkai, K.;Shimizu, M. , Shizuoka Daigaku Nogakubu Kenkyu Hokuku / v.32,pp.41-58, 1982
  22. Effect of polysaccharides from Ganoderma applanatum on immune responses. I. Enhancing effect on the induction of delayed hypersensitivity in mice , Nakashima, S.;Umeda, Y.;Kanada, T. , Microbiol. Immunol. / v.23,pp.501-513, 1979
  23. Production of milk-clotting enzymes by basidiomycetes , Nerud, F.;Misurcova, Z.;Musilek, V. , Folia Microbiol.(Proque) / v.34,pp.310-315, 1989
  24. Bitter triterpenoids from the fungus Ganoderma applanatum , Nishitoba, T.;Goto, S.;Sato, H.;Sakamura, S. , Phytochemistry / v.28,pp.193-197, 1988
  25. Antibacterial synergism. A proposal for chmotherapeutic potentiation between trimethoprim and sulfamethoxazole , Poe, M. , Science / v.194,pp.533, 1976
  26. Triterpenes. LXIII. Triterpenes and steroids from Ganoderma applanatum , Protiva, J.;Skorkovska, H.;Urban, J.;Vystrcil, A. , Collect. Czech. Chem. Commun. / v.45,pp.2710-2713, 1980
  27. Steroids from Ganoderma applanatum , Ripperger, H.;Budzikiewicz, H. , Phytochemistry / v.14,pp.2297-2298, 1975
  28. Antibiotic substances from basidiomycetes. I , Robbins, W.J.;Kavanagh, F.;Hervey, A. , Pleurotus Proceeding of the National Academy of Science / v.33,pp.171-176, 1947
  29. Efficacy and safty of aztreonam-clindamycin versus tobramycin-clindamycin in the treatment of lower respiratory tract infections caused by aerobic Gram-negative bacilli , Rodriguez, J.R.;Ramirez Ronda, C.H.;Nevarez, M. , Antimicrob. Agents Chemother / v.27,pp.246-251, 1985
  30. The emergence of isoiazidresistant cultures in patients with pulmonary tuverculosis during treatment with isoniazid alone or isoniazid plus PAS , Selkon, J.B.;Devadatta, S.;Kulkarnia, K.G.;Mitchison, D.A.;Narayana, A.S.L.;Narayana Nair, C.;Ramachandran, K. , Bull. W.H.O. / v.31,pp.273-294, 1964
  31. Isolation and identification of ergosterol peroxide from Cetraria richardsonii and Ganoderma applanatum , Svridonov, V.N.;Strigina, L.I. , Khim. Prir. Soedin. / v.5,pp.669, 1976
  32. Antibiotics in Laboratory Medicine , Lorian, V.M.D. , / v.,pp.537-545, 1991
  33. Chemotherapy of tuberculosis;Pharmacological Basis of Therapeutics, 5 , Weistein, L.;Goodman, L.S.(ed.);Gilman, A.(ed.) , / v.,pp.1214, 1975
  34. Chemical constituents of fungi. II. Coenzymes $Q_9$ from Ganoderma applanatum , Yamada, Y.;Hsu, C.S.;Iguchi, K.;Suzuki, M. , Tohoku Yakka Daigaku Kenkyu Nempo / v.23,pp.290-292, 1973

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