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논문 상세정보

당뇨 모델쥐의 간관 췌장에서 타우린이 지질과산화물 생성과 글루타티온 의존성 효소의 활성에 미치는 영향

Effect of Taurine Supplement on the Lipid Peroxide Formation and the Activity of Glutathione-Dependent Enzyme in the Liver and Islet of Diabetic Model Mice

한국영양식량학회지 v.24 no.2 , 1995년, pp.195 - 201  
초록

당뇨 모델에서 타우린의 보강에 의한 지질과산화물의 생성과 GSH 관련 효소들의 활성에 미치는 영향을 알아보고자 alioxan을 이용한 I형과 KK-mouse에 고열량식이를 이용하여 II형 당뇨를 유도하였다. I형과 II형 각각에 정상대조군, 타우린보강군, 당뇨군, 타우린보강 당뇨군을 두어, 모두 8개 군으로 나누었으며, 타우린의 보강은 7일 동안 5%(w/v) 수준으로 자유로이 마시게 하였다. 간과 췌장에서 malondialdehycel(MDA), gluta-thione peroxidase(GPX), glutathions S-transferase(GST)의 활성을 측정하였다. 간조직에서 지질과산화물의 함량은 I형의 경우 당뇨군에서 매우 증가했고 타우린 보강에 의한 유의적으로 감소한 것을 볼 수 있었으며, II형에서는 타우린보강에 의해 유의적인 차이가 없었다. 췌장도 간과 같은 결과를 나타내었다. GPX의 활성은 간에서 I형 당뇨군이 유의적으로 증가했으나, II형 당뇨군에서는 유의적으로 감소했다. 타우린의 보강에 의해 GPX활성에는 유의적인 차이가 없었으며 췌장에서도 간과 비슷한 결과를 보였다. GST의 경우에도 당뇨 유도에 의한 활성 변화는 있었으나 타우린의 보강에 의한 활성 변화는 보이지 않았다. 이상의 결과들로 미루어 당뇨에 있어 타우린의 항산화작용은 당뇨 모델의 종류에 따라 다르며, GSH 관련 효소들의 활성변화 보다는 I형 당뇨 모델의 간과 췌장에서 지질과산화물의 생성을 억제하는 작용을 하리라고 생각 된다.

Abstract

In this study we wanted to investigate the effect of taurine supplement on the lipid peroxide formation and the activities of glutathione(GSH) dependent enzyme in diabetic model mice. We induce type I diabetes mellitus with alloxan injeciton in ICR mice and type II with high calorie diet in genetically hyperglycemic KK mice. Taurine was given in drinking water at the level of 5%(w/v) for seven days. In type I diabetic model, the malondialdehyde(MDA) of liver and islet significantly increased compared to control group and they significantly decreased by taurine supplement. In type II diabetic model, the concentration of MDA was not changed by taurine supplement. The activities of GSH-peroxidase(GPX) of liver and islet increased in type I diabetic group while decreased in type II. GPX activities were not changed by taurine supplement in the liver of both types but increased in the islet of type II. Taurine supplement has no effect on the activities of GSH S-transferase(GST) in both types. From these results, we suggest that taurine supplement protect against lipid peroxide formation in diabetic model of type I.

저자의 다른 논문

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이 논문을 인용한 문헌 (5)

  1. 1998. "The Effect of Butanol Fraction of Polygonatum odoratum with Vitamin E on Blood Glucose Levels and Lipid Peroxidations in Streptozotocin-Induced Diabetic Rats" 韓國營養學會誌 = The Korean journal of nutrition., 31(9): 1385~1393 
  2. 1999. "Effects of Taurine and $\beta$-alanine on Blood Glucose and Blood Lipid Concentrations in Streptozotocin-induced Diabetic Rats" 韓國營養學會誌 = The Korean journal of nutrition., 32(3): 213~220 
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  5. Kim, Ae-Jung ; Lim, Young-Hee ; Kim, Moung-Hee ; Kim, Mi-Won 2007. "The Development of Yellow Layer Cake with Cuttlefish Ink" 한국식품영양학회지 = The Korean journal of food and nutrition, 20(3): 311~316 

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