Abstract

Purpose : To determine whether 1H magnetic resonance spectroscopy (MRS) is useful in differentiatingidiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP), based on metabolite ratios.Materials and Methods : Using a 1.5 T MR Unit, single voxel 1H MRS using STEAM with a TR of 2000ms and a TE of135ms was performed in seven PD and eight PSP patients. Five age-matched volunteers(mean age, 63 years) andanother five younger healthy volunteers(mean age, 30 years) were studied as normal controls. The regions ofinterest were the putamen and pallidum, with a size of 2 X 2 X 2cm. After measuring the spectral intensities ofeach metabolite (N-acetylaspartate=NAA, choline=Cho, creatine=Cr and lactate), relative peak height ratios ofNAA/Cr, Cho/Cr and Naa/Cho, and lactate levels among four groups were compared. Results : NAA/Cho and NAA/Crratios were statistically lower in the PSP group than the IPD group (1.21 $\pm$ 0.26 versus 1.45 $\pm$ 0.20, and 1.26 $\pm$0.23 versus 1.38 $\pm$ 0.19, respectively : p<0.05). NAA/Cho and NAA/Cr ratios were significantly lower inage-matched controls than in younger normal controls (1.39 $\pm$ 0.21 versus 1.76 $\pm$ 0.15, and 1.36 $\pm$ 0.13 versus1.79 $\pm$ 0.17, respectively : p0.05). Cho/Cr ratios were not different among four groups. Lactate was not detectedin any patients. Conclusion : NAA/Cho and NAA/Cr ratios in the corpus striatum were significantly lower in the PSPgroup than in the age-matched control and IPD groups. These results suggest that loss of neuron cells in thecorpus striatum is more prominent in PSP than in IPD, and that NAA/Cho and NAA/Cr ratios may help in differentialdiagnosis of IPD and PSP.

주제어

#Magnetic resonance(MR), spectroscopy   #Brain, atrophy   #Brain, diseases  

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참고문헌 (15)

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이 논문을 인용한 문헌 (1)

1. Lim, Myung Kwan ; Suh, Chang Hae ; Cho, Young Kook ; Kim, Jin Hee ; Lee, Jung Hee ; Lim, Tae Hwan 1998. "H MR Spectroscopy of the Normal Human Brains : Comparison of Aytinated Prescan Method with Manual Method" 대한방사선의학회지 = Journal of the Korean Radiological Society, 38(3): 385~390  원문보기 상세보기