$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

Purpose : To determine whether 1H magnetic resonance spectroscopy (MRS) is useful in differentiatingidiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP), based on metabolite ratios.Materials and Methods : Using a 1.5 T MR Unit, single voxel 1H MRS using STEAM with a TR of 2000ms and a TE of135ms was performed in seven PD and eight PSP patients. Five age-matched volunteers(mean age, 63 years) andanother five younger healthy volunteers(mean age, 30 years) were studied as normal controls. The regions ofinterest were the putamen and pallidum, with a size of 2 X 2 X 2cm. After measuring the spectral intensities ofeach metabolite (N-acetylaspartate=NAA, choline=Cho, creatine=Cr and lactate), relative peak height ratios ofNAA/Cr, Cho/Cr and Naa/Cho, and lactate levels among four groups were compared. Results : NAA/Cho and NAA/Crratios were statistically lower in the PSP group than the IPD group (1.21 $\pm$ 0.26 versus 1.45 $\pm$ 0.20, and 1.26 $\pm$0.23 versus 1.38 $\pm$ 0.19, respectively : p<0.05). NAA/Cho and NAA/Cr ratios were significantly lower inage-matched controls than in younger normal controls (1.39 $\pm$ 0.21 versus 1.76 $\pm$ 0.15, and 1.36 $\pm$ 0.13 versus1.79 $\pm$ 0.17, respectively : p0.05). Cho/Cr ratios were not different among four groups. Lactate was not detectedin any patients. Conclusion : NAA/Cho and NAA/Cr ratios in the corpus striatum were significantly lower in the PSPgroup than in the age-matched control and IPD groups. These results suggest that loss of neuron cells in thecorpus striatum is more prominent in PSP than in IPD, and that NAA/Cho and NAA/Cr ratios may help in differentialdiagnosis of IPD and PSP.

참고문헌 (15)

  1. Imaging of the aging brain : part 1. normal findings , Drayer BP , Radiology / v.166,pp.785-796, 1988
  2. Prevalence and natural history of progressive supranuclear palsy , Golbe LI;Davis PH;Schoenberg BS(et al.) , Neurology / v.38,pp.1031-1034, 1988
  3. Core assessment program for intracerebral transplantation(CAPIT) , Langston JW;Widner H;Goetz CG;Brooks D;Fahn S;Freeman T;Watts R , Mov Disord / v.7,pp.2-13, 1992
  4. Progressive supranuclear palsy : a heterogeneous degeneration involving the brainstem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia , Steele JC;Richardson JC;Olszewski J , Arch Neurol / v.10,pp.333-359, 1964
  5. Proton MR spectroscopy of the brain in 14 patients with Parkinson disease , Bowen BC;Block RE;Snachez-Ramos J(et al.) , AJNR / v.16,pp.61-68, 1995
  6. Parkinsonism , Fahn S;Rowland LP(ed.) , Merritt's Textbook of Neurology(9th Ed.) / v.,pp.713-730, 1995
  7. Differing patterns of stiatal 18F fluorodoa uptake in Pakinson's disease, multiple system atrophy, and progressive supranucler palsy , Brooks DJ;Ibanez V;Sawle G(et al) , Ann Neurol / v.28,pp.547-555, 1990
  8. Magnetic resonance imaging in Parkinson's disease and parkinsonian syndromes , Stern MB;Braffman BH;Skolnick BE(et al.) , Neurology / v.39,pp.1524-1526, 1989
  9. Proton MR spectroscopy of the striatum in patients with Parkinson's disease. Abstract Book SMRM , Heerschap A;Zijlmans JCM;Koster A;Boogert HJ;Thijssen HOM;Horstink HWIM , 11th Annual Meeting / v.,pp.1949, 1992
  10. The clinical features and natural history of Steele-Richardson-Olszewski disease (progressive supranuclear psalsy) , Maher ER;Lees AJ , Neurology / v.36,pp.1005-1009, 1986
  11. MR imaging in progressive supranuclear palsy and Shy-Drager syndrome , Savoiardo M;Strada L;Girotti F(et al.) , J Comput Assist Tomogr / v.13,pp.555-560, 1989
  12. Parkinson plus syndrome : diagnosis using high field MR imaging of brain iron , Drayer BP;Olanow W;Burger P(et al) , Radiology / v.159,pp.493-498, 1989
  13. localized proton NMR spectroscopy in the striatum of patients with idiopathic Parkinson's disease : A multicenter poilot study , Holshouser BA;Komu M;Moller HE(et al.) , Magn Reson Med / v.33,pp.589-594, 1995
  14. Accuracy of clinical diagnosis of idiopathic Parkinson's disease-A clinico-pathological study of 100 cases , Hughes AJ;Daniel SE;Kilford L;lees AJ , J Neurol Neurosug Psychiatry / v.55,pp.181-184, 1992
  15. Progressive supranucler palsy : postmortem chemical analysis , Young AB , Ann Neurol / v.18,pp.521-522, 1985

이 논문을 인용한 문헌 (1)

  1. Lim, Myung Kwan ; Suh, Chang Hae ; Cho, Young Kook ; Kim, Jin Hee ; Lee, Jung Hee ; Lim, Tae Hwan 1998. "H MR Spectroscopy of the Normal Human Brains : Comparison of Aytinated Prescan Method with Manual Method" 대한방사선의학회지 = Journal of the Korean Radiological Society, 38(3): 385~390 

원문보기

원문 PDF 다운로드

  • 원문 PDF 정보가 존재하지 않습니다.

원문 URL 링크

  • 원문 URL 링크 정보가 존재하지 않습니다.

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일