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Bacterial Resistance to LB20304, a New Fluoroquinolone Antibiotic 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.19 no.5, 1996년, pp.400 - 405  

Kim, Mu-Yong (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ,  Paek, Kyoung-Sook (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ,  Kim, In-Chull (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ,  Kwak, Jin-Hwan (School of Bioscience and Food Technology, Handong University)

Abstract AI-Helper 아이콘AI-Helper

In vitro studies were conducted to dertermine the frequency rate of spontaneous resistance to LB20304 and to dertermine whether cross-resistance to other antimicrobial agents develops. In eight strains of bacteria, the frequency of mutation to LB20304 at the concentrations of four and eight times t...

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참고문헌 (16)

  1. J. Antimicrob. Chemother. J. F. Acar 26 Supply B 207 1990 10.1093/jac/26.suppl_B.207 Acar, J. F. and Francoual, S., The clinical problems of bacterial resistance to the new quinolones.J. Antimicrob. Chemother. 26 (Supply B), 207-213 (1990). 

  2. Drugs F. W. Goldstein 49 Supply. 2 36 1995 10.2165/00003495-199500492-00007 Goldstein, F. W. and Acar, J. F., Epidermiology of quinolone resistance: Europe and North and South America.Drugs, 49 (Supply. 2), 36-42 (1995). 

  3. Antimicrob. Agents Chemother. D. C. Hooper 29 639 1986 10.1128/AAC.29.4.639 Hooper, D. C., Wolfson, J. S., Sousa, K. S., Tung, C., McHugh, G. L. and Swartz, M. N., Genetic and biochemical characterization of norfloxacin resistance inEscherichia coli.Antimicrob. Agents Chemother., 29, 639-644 (1986). 

  4. Y. K. Kim 148 1995 Synthesis and antibacterial activities of LB20304: a new fluoronaphthyridone antibiotic containing novel oxime functionalized pyrrolidine Kim, Y. K., Choi, H., Kim, S. H., Chang, J. H., Nam, D. H., Kim, Y. Z., Kwak, J. H. and Hong, C. Y., Synthesis and antibacterial activities of LB20304: a new fluoronaphthyridone antibiotic containing novel oxime functionalized pyrrolidine.In Abstracts of the 35th Interscience Conference on Antimicrobial agents and Chemotherapy, San Francisco, CA, 1995. Abstract F204, p. 148. American Society for Microbiology, Washington, D.C. (1995). 

  5. Arch. Pharm. Res. M. Y. Kim 19 52 1996 10.1007/BF02976820 Kim, M. Y., Oh, J. I., Paek, K. S., Hong, C. Y., Kim, I. C. and Kwak, J. H.,In vitro activities of LB20304, a new fluoroquinolone,Arch. Pharm. Res. 19, 52-59 (1996). 

  6. Antimicrob. Agents Chemother. X. Z. Li 38 1732 1994 10.1128/AAC.38.8.1732 Li, X. Z., Livermore, D. M. and Nikaido, H., Role of efflux pump(s) in intrisic resistance of Pseudompnas aeruginosa: resistance to tetracycline, chloramphenicol and norfloxacin.Antimicrob. Agents Chemother., 38, 1732-1741 (1994). 

  7. National Committee for Clinical Laboratory Standards 1993 Approved standard M7-A3 Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically Third edition National Committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, Third edition; Approved standard M7-A3. NCCLS, Villanova, Pa. (1993). 

  8. Rev. Infect. Dis. H. C. Neu 10 Suppl. 1 S57 1988 10.1093/clinids/10.Supplement_1.S57 Neu, H. C., Bacterial resistance to fluoroquinolones.Rev. Infect. Dis. 10 (Suppl. 1), S57-S62 (1988). 

  9. J. I. Oh 148 1995 In vitro andin vivo antibacterial activities of LB20304, a new fluoronaphthyridone Oh, J. I., Paek, K. S., Kim, M. Y., Seo, S. M., Lee, Y. H., Hong, C.-Y., Nam, D. H., Kim, Y. Z., Kim, I. C. and Kwak, J. H.,In vitro andin vivo antibacterial activities of LB20304, a new fluoronaphthyridone.In Abstracts of the 35th Interscience Conference on Antimicrobial agents and Chemotherapy, San Francisco, CA, 1995. Abstract F205, p. 148. American Society for Microbiology, Washington, D.C. (1995). 

  10. Antimicrob. Agents Chemother. J. I. Oh 40 1564 1996 10.1128/AAC.40.6.1564 Oh, J. I., Paek, K. S., Ahn, M. J., Kim, M. Y., Hong, C. Y., Kim, I. C. and Kwak, J. H.,In vitro andin vivo evaluations of LB20304, a new fluoronaphthyridone.Antimicrob. Agents Chemother., 40, 1564-1568 (1996). 

  11. Arch. Pharm. Res. K. S. Paek 19 143 1996 10.1007/BF02976850 Paek, K. S., Ahn, M. J., Kim, M. Y., Kim, I. C. and Kwak, J. H., Factors affectingin vitro activity of LB 20304, a new fluoroquinolone.Arch. Pharm. Res., 19, 143-147 (1996). 

  12. J. Antimicrob. Chemother. L. J. V. Piddock 27 399 1991 10.1093/jac/27.4.399 Piddock, L. J. V., Mechanisms of quinolone uptake into bacterial cells.J. Antimicrob. Chemother., 27, 399-405 (1991). 

  13. Drugs L. J. V. Piddock 49 Suppl. 2 29 1995 10.2165/00003495-199500492-00006 Piddock, L. J. V., Mechanisms of resistance to fluoroquinolones: State-of-the-art 1992-1994.Drugs 49 (Suppl. 2), 29-35 (1995). 

  14. Antimicrob. Agents Chemother. C. C. Sanders 26 797 1984 10.1128/AAC.26.6.797 Sanders, C. C., Sanders, W. E., Jr., Goering, R. V. and Werner, V., Selection of multiple antibiotic resistance by quinolones, β-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes.Antimicrob. Agents Chemother., 26, 797-801 (1984). 

  15. Antimicrob. Agents Chemother. K. Sato 30 777 1986 10.1128/AAC.30.5.777 Sato, K., Inoue, Y., Fujii, T., Aoyama, H., Inoue, M. and Mitsuhashi, S., Purification and properties of DNA gyrase from a fluoroquinolone resistant strain ofEscherichia coli.Antimicrob. Agents Chemother., 30, 777-780 (1986). 

  16. Mol. Gen. Genet. J. I. Yamagishi 204 367 1986 10.1007/BF00331012 Yamagishi, J. I., Yoshida, H., Yamayoshi, M. and Nakamura, S., Nalidixic acid resistant mutations of thegyrB gene ofEscherichia, coli.Mol. Gen. Genet., 204, 367-373 (1986). 

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