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논문 상세정보

Abstract

Palmatine, an protoberberine isoquinoline alkaloid, has been found to inhibit dopamine biosynthesis by reducing tyrosine hydroxylase (TH) activity in PC12 cells (Lee and Kim, 1996). We have therefore investigated the effects of palmatine on bovine adrenal TH. Palmatine showed a mild inhibition on bovine adrenal TH (36.4% inhibition at concentration of $200\muM$). Bovine adrenal TH was inhibited competitively by palmatine with a substrate L-tyrosine. The Ki value was found to be 0.67 mM. This result suggests that the inhibition of TH activity by palmatine may be partially involved in the reduction of dopamine biosynthesis in PC12 cells.

참고문헌 (17)

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이 논문을 인용한 문헌 (4)

  1. Jin, Chun-Mei ; Lee, Jae-Joon ; Yin, Shou-Yu ; Kim, Yu-Mi ; Kim, Young-Kyoon ; Rhu, Shi-Yong ; Lee, Myung-Koo 2003. "Effects of Liriodenine on Dopamine Biosynthesis in PC12 Cells" 생약학회지, 34(1): 55~59 
  2. Kim, Yu-Mi ; Lee, Jae-Joon ; Jin, Chun-Mei ; Yang, Yoo-Jung ; Kang, Min-Hee ; Lee, Myung-Koo 2003. "Effects of Chelidonine on L-DOPA-Induced Cytotoxicity in PC12 Cells" 생약학회지, 34(3): 242~245 
  3. 2003. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 26(7): 540~544 
  4. Lee, Sung-Ja ; Bae, Jung-Mi ; Suk, Kui-Duk 2004. "Inhibitory Effects of Cuscuta japonica Extract and C. australis Extract on Mushroom Tyrosinase Activity" 생약학회지, 35(4): 380~383 

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