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논문 상세정보

한국산 잡견에서 허혈시 장시간심근보존을 위한 각 심정지액간 효과의 차이

Comparison of Three Cardioplegic Solutions for Prolonged Cardiac Preservation During Ischemia in Korean Mongrel Dogs

초록

한국산 잡견을 대상으로 세 종류의 심정지액으로 심장을 정지 보존 후,심장을 적출하여 $0^{\circ}C$에서 보존하면서 일정한 시간별로 6회에 걸쳐 좌심실 근육조직을 채취하여 -75$^{\circ}C$ 냉동고에 저장한 후,초고속 액체 크로마토그라피법으로 purine metabolites를 측정하였다. UW 용액(UWS)군의 ATP 농도는 St. Thomas 용액 (5751군과 혈성 심정 지액 (BCPS)군에 비하여 높으나, 575 군과 BCPS 군 간에는 특이한 차이가 없었다. UWS 군과 BCPS 군의 ADP 농도가 4,8, 12, 24 시간대의 575 군보다 높지만, UWS 군과 BCPS 군 사이에는 특이한 차이가 없었다. AMP 농도는 세군 모두에서 변화가 많지 않았고, adenosine, inoslne, hypoxanthlnc 농도는 시간 경과 에 따라 점차 증가하였고, xanthine의 농도는 매우 소량이어서 비교가 불가능하였다. 본 연구 결과, UW용액이 장시간의 심근보존능력에는 아직 문제점이 있으나, 전신 저체온법을 동시에 시행한 St. Thomas 용액이나 혈성 용액 보다는 보다 우수한 보존용액으로 사료된다.

Abstract

To compare the efficacy of cardiac preservation, we examined purine metabolites during 24 hours of cold storage($0^{\circ}C$) of the Korean ongrel dog hearts after using three different types of cardioplegic solutions. The hypothermic arrest with total cardiopulmonAry bypass method was employed in 51. Thomas solution(575) and blood cardioplegic solution(BCPS) preservation cases. Specimens were analyzed for levels of adenine nucleotides and their precursors by high performance liquid chromatography. The ATP content in the UW(University of Wisconsin) solution group tends to be higher than that of the combined hypothermic arrest group(575 and BCPS groups) after 2,4,8, and 12 hours of preservation respectively, but there were no significant differences between 575 and BCPS groups. The ADP contents in the UWS and BCPS groups were higher than that of the 575 group at 4,8, 12, and 24 hours, but the difference was not statistically significant between UWS and BCPS groups. The AMP contents did not change significantly in the three groups. The adenosine, Inosine, and hypoxanthine concentrations increased progressively, but the lev l of xanthine was very low in the three groups.

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