• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Detection of Rifampin Resistance Mutation and Its Altered Nucleotide Sequences in Mycobacterium leprae Isolated from Korean Patients with Leprosy

The journal of microbiology v.34 no.3 , 1996년, pp.236 - 240  

Rifampin is the most powerful drug for treating leprosy and tuberculosis today. It inhibits initiation and elongation of RNA transcription by binding to $\beta$-subunit of RNA polymerase, leading to kill mycobacteria. We isolated one variant strain of Mycobacterium leprae from 24 Korean leprosy patients who are less susceptible to rifampin or have suffered from relapse by polymerase chain reaction and single strand conformation polymorphism (PCR-SSCP) of the rpoB gene. Direct sequencing of the rpoB region of M. leprae variant revealed missense mutations which altered the amino acids sequenceof RpoB to Ser-464, Arg-465, Arg-467 and Ala-468. This is the first finding on rpoB gene mutation of M. leprae from Korean patients ; moreover the mutant type was found to be different from the previously reported cases in other countries.

참고문헌 (17)

  1. Detection of Mycobacterium leprae and the potential for monitoring antileprosy drug therapy directly from skin biopsies by PCR , Williams, D.L. , Molecular and Cellular Probes / v.6,pp.401-410, 1992
  2. A non-radioactive method for simultaneous detection of single-strand conformation polymorphisms (SSCP) and heteroduplexes , Lee, S.T.;S.K. Park;K.H. Lee;S.A. Holmes;R.A. Spritz , Mol. Cells / v.5,pp.668-672, 1995
  3. A simple and rapid technique for the detection of rifampin resistance in Mycobacterium leprae , Honore, N.;E. Perrani;A. Telenti;J. Grosset;S.T. Cole , Int. J. Lep. / v.61,pp.600-604, 1993
  4. Screening for mutations by RNA single-strand conformation polymorphism (rSSCP): comparison with DNA-SSCP , Sakar, G.;Yoon, H.S.;S.S. Sommer , Nucleic. Acids. Res. / v.20,pp.871-878, 1992
  5. Study of 39 documented relapses of multibacillary leprosy after treatment with rifampin , Groset, J.H.;C.-C. Guelpa-Lauras;P. Bobin;G. Brucker;J.-L. Cartel;M. Constant-Desportes;B. Flageul;M. Frederic;J.-C. Guillaume;J. Millan , Intl. J. Lep. / v.57,pp.607-614, 1989
  6. Detection of rifampin resistance mutation in Mycobacterium tuberculosis and M. leprae. 994 , Imboden, P.;C. Stewart;T. Bodmer;A. Telenti;D.H. Persing(ed.) , Diagnostic molecular microbiology, principles and applications / v.,pp.519-526, 1994
  7. Implications of multidrug resistance of the future of short-course chemotherapy of tuberculosis: a molecular study , Heym, B.;N. Honore;C. Truffot-Pernot;A. Banerjee;C/ Schurra;W.R. Jacobs Jr.;J.D.A. van Embden;J.H. Grosset;S.T. Cole , Lancet / v.344,pp.293-298, 1994
  8. Nucleotide sequence of the first cosmid from the Mycobacterium leprae genome project: Structure and function of the Rif-Str regions , Honore,N.T.;S. Berght;S. Chanteau;F. Doucet-Populaire;K. Eiglmeier;T. Garnier;C. Georges;P. Launois;T. Limpaiboon;S. Newton;K. Niang;P. Del Portillo;G.R. Ramesh;P. Reddi;P.R. Ridel;N. Sittisombut;S. Wu-Hunter;S.T. Cole , Mol. Microbiol. / v.7,pp.207-214, 1993
  9. A rapid method for the detection of potentially viable Mycobacterium leprae in human biopsies: A novel application of PCR , Words, S.A.;S.T. Cole , FRMS Mocrobiol. Lett. / v.65,pp.305-310, 1989
  10. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction , Orita, M.;Y. Suzuki;T. Sekiya;K. Hayashi , Genomics / v.5,pp.874-879, 1989
  11. Molecular basis of rifampin resistance in Mycobacterium leprae , Honore, N.;S.T. Cole , Antimicrob. Agents. Chemother / v.37,pp.414-418, 1993
  12. Detection of polymorphisms of human DNA by gel electrophoresis as single-stand conformation polymorphisms , Orita, M.;H. Iwahana;H. Kanazawa;K. Hayashi;T. Sekiya , Proc. Natl. Acad. Sci. USA / v.86,pp.2766-2770, 1989
  13. The sensitivity of single=stand conformation polymorphism analysis for the detection of single base substitutions , Sheffield, V.C.;J.S. Back;A.E. Kwitek;D.W. Sandstrom;E.M. Stone , Genomics / v.16,pp.325-332, 1993
  14. Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance , Jin, D.J.;C.A. Gross , J. Mol. Biol. / v.202,pp.45-58, 1988
  15. Detection of rifampicin-resistance mutation in Mycobacterium tuberculosis , Telenti, A.;P. Imboden;F. Marchesi;D. Lowrie;S. Cole;M.J. Colston;L. Matter;K. Schopfer;T. Bodmer , Lancet / v.341,pp.647-650, 1993
  16. Rifampin-resistant leprosy , Jacobson, R.R.;R.C. Hastings , Lancet / v.2,pp.1304-1305, 1976
  17. The euglena gracillis chloroplast rpoB gene. Novel gene organization and transcription of the RNA prolymerase subunit operon , Yepiz-Plascencia, G.M.;Radebaugh, C.A.;R.B. Hallick , Nucleic. Acids. Res. / v.18,pp.1869-1878, 1990

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일