$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

Exposure of splenocytes to 2-chloroethylethyl sulfide (CEES) resulted in the cell death, and the cytotoxicity of CEES was prevented by inhibitors of lysosomal hydrolases. Therefore, it has been postulated that the cytotoxicity of CEES may be partially due to the lysosomal labilization. This study, based on this mechanism, was undertaken to determine whether aminoglycoside antibiotics as inhibitors of lysosomal phospholipases and their combinations with other lysosome stabilizers can be useful as a treatment to reduce the CEES toxicity in mice. 2-Chloroethylethyl sulfide (20 mg/kg body weight) was injected ip into female ICR mice, and candidate compounds were administered ip before or after the CEES challenge. Kanamycin (40 mg/kg body weight) as effective as deferoxamine (100 mg/kg body weight) enhanced the survival rate after 5 days of intoxication from 10% of control to 50 - 60%. The most effective was found to be the combination of kanamycin, cycloheximide, deferoxamine and dextrose showing an almost full protection against 2LD50 of CEES. Consistent with the protection of the CEES toxicity, the decrease of body weight in mice intoxicated with CEES was effectively prevented by kanamycin or its combinations. It is suggested that kanamycin or its combination (kanamycin, cycloheximide, deferoxamine and dextrose) would be one of effective antidotes against the CEES poisoning in mice.

참고문헌 (28)

  1. Protective effect of poly(ADP-ribose) polymerase inhibitors on 2-chloroethylethyl sulfide-induced cytotoxicity in murine lymphocytes , Choi, D.-S.;Park, Y.-K.;Kim, Y.-B.;Hur, G.-H.;Sok, D.-E. , Korean Biochem. J. / v.27,pp.544-549, 1994
  2. In vitro toxicological lesions of bis(betachloroethyl)sulfide (BCES) on human epidermis reconstituted in culture. Morphological alterations and biochemical depletion of glutathione , Gentilhomme, E.;Neveux, Y.;Hua, A.;Thiriot, C.;Faure, M.;Thivolet, J. , Toxicol. in Vitro / v.6,pp.139-147, 1992
  3. Early cytotoxic effects induced by bis-chloroethyl sulphide (sulfur mustard_: $[Ca^{2+}]$, rise and time-dependent inhibition of B77 fibroblast serum response , Hua, A.;Daniel, R.;Jasseron, M.P.;Thiriot, C. , J. Appl. Toxicol. / v.13,pp.161-168, 1993
  4. Effects of specific inhibitors of cellular functions on sulfur mustard-induced cell death , Clayson, E.;Kelly, S.A.;Meier, H.L. , Cell Biol. Toxicol. / v.9,pp.165-175, 1993
  5. Papirmeister, B.;Feister, A.J.;Robinson, S.I.;Ford, R.D. , Medical Defense against Mustard Gas: Toxic Mechanisms and Pharmacological Implications / v.,pp., 1991
  6. Effects of nicotinamide on biochemical changes and microblistering induced by sulfur mustard in human skin organ cultures , Mol, M.A.E.;Vries, R.;Kluivers, A.W. , Toxicol. Appl. Pharmacol. / v.107,pp.439-449, 1991
  7. The release of arylsulfatase from liver lysosomes exposed to 2-chloroethylethyl sulfide , Shin, S.;Choi, D.-S.;Kim, Y.-B.;Cha, S.-H.;Sok, D.-E. , Chem.-Biol. Interact. / v.97,pp.229-238, 1995
  8. Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress , Sakaida, I.;Kyle, M.E.;Farber, J.L. , Mol. Pharmacol. / v.37,pp.435-442, 1990
  9. Molecular basis for mustard-induced vesication , Papirmeister, B.;Gross, C.L.;Meier, H.L.;Petrali, J.P.;Johnson, J.B. , Fund. Appl. Toxicol. / v.5,pp.S134-S140, 1985
  10. Effect of cycloheximide on the bone marrow toxicity of nitrogen mustard , Weissberg, J.B.;Herion, J.C.;Walker, R.I.;Palmer, J.G. , Cancer Res. / v.38,pp.1523-1527, 1979
  11. Cellular pharmacology of deferrioxamine B and derivatives in cultured rat hepatocytes in relation to iron mobilization , Laub, R.;Schneider, Y.-J.;Octave, J.-N.;Trouet, A.;Crichton, R.R. , Biochem. Pharmacol. / v.34,pp.1175-1183, 1985
  12. Responses of mouse brain to a singel subcutaneous injection of the monofunctional sulfur mustard, butyl 2-chloroethyl sulfide (BCS) , Elsayed, N.M.;Omaye, S.T.;Klain, G.J.;Inase, J.L.;Hahlberg, E.T.;Wheeler, C.R.;Korte, D.W., Jr. , Toxicology / v.58,pp.11-20, 1989
  13. An additional mechanism for the cytotoxicity of 2-chloroethyethyl sulfide in spleen lymphocytes; lysosomal labilization , Choi, D.-S.;Shin, S.-H.;Kim, Y.-B.;Cha, S.-H.;Sok, D.-E. , J. Biochem. Mol. Biol. / v.28,pp.79-82, 1995
  14. Reversal of nitrogen mustard intoxication by anti-histamines , Field, J.B.;Mireles, A.;Dolendo, E.C.;Ershoff, B.H. , Proc. Soc. Exp. Biol. Med. / v.115,pp.1060-1062, 1964
  15. Therapeutic efficacy of saline and glucose-saline against dermally applied sulphur mustard intoxication in mice , Sugendran, K.;Jeevaratnam, K.;Vijayaraghavan, R.;Das Gupta, S. , Def. Sci. J. / v.44,pp.21-23, 1994
  16. Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron over-load , Myers, B.M.;Prendergast, F.G.;Holman, R.;Kuntz, S.M.;LaRusso, N.F. , J. Clin. Invest. / v.88,pp.1207-1215, 1991
  17. Inhibition of hepatocyte protein degradation by methylaminopurines and inhibitors of protein synthesis , Kovacs, A.L.;Seglen, P.O. , Biochim. Biophys. Acta / v.676,pp.213-220, 1981
  18. Reactive species and their accumulation on radical damaged proteins , Dean, R.T.;Gieseg, S.;Davies, M.J. , Trends Pharmacol. Sci. / v.18,pp.437-441, 1993
  19. Free radical-mediated lung response to the monofunctional sulfur mustard butyl 2-chloroethyl sulfide after subcutaneous injection , Elsayed, N.M.;Omaye, S.T.;Klain, G.J.;Korte, D.W., Jr. , Toxicology / v.72,pp.153-165, 1992
  20. Statistics for toxicologists , Gad, S.C.;Weil, C.S.;Hayes, W.(Ed.) , Principles and Methods of Toxicology / v.,pp.273, 1982
  21. The protective effect of different drugs in rats poisoned by sulfur and nitrogen mustards , Vojvodic, V.;Milosavljevic, Z.;Boskovic, B.;Bojanic, N. , Fund. Appl. Toxicol. / v.5,pp.S160-S168, 1985
  22. Dermal intoxication of mice with bis(2-chloroethyl)sulphide and the protective effect of flavonoids , Vijayaraghavan, R.;Sugendran, K.;Pant, S.C.;Husain, K.;Malhotra, R.C. , Toxicology / v.69,pp.35-42, 1991
  23. Enhanced lysosomal phospholipid degradation and lysophospholipid production due to free radicals , Weglicki, W.B.;Dickens, B.F.;Mak, I.T. , Biochem. Biophys. Res. Comm. / v.124,pp.229-235, 1984
  24. Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membrane , Ray, R.;Legere, R.H.;Majerus, B.J.;Petrali, J.P. , Toxicol. Appl. Pharmacol. / v.131,pp.44-52, 1995
  25. Protection by lysosomal hydrolase inhibitors against cytotoxicity of 2-chloroethylethyl sulfide , Sok, D.-E.;Choi, D.-S.;Park, Y.-K.;Kim, Y.-B.;Cha, S.-H. , Fd Chem. Toxicol. / v.33,pp.597-600, 1995
  26. Inhibitory effect of Fusarium T2-Toxin on lymphoid DNA and protein synthesis , Rosenberg, Y.;Lafrage-Frayssinet, C. , Toxicol. Appl. Pharmacol. / v.70,pp.283-288, 1973
  27. Protective effects of N-acetylcysteine and sodium thiosulfate on sulfur mustard poisoning in mice , Balali-Mood, M.;National Defence Research Establishment(ed.) , Supplement to Proceedings of the Third International Symposium on Protection Against Chemical Warfare Agents / v.,pp.201-210, 1989
  28. The determination and prevention of cytotoxic effects induced in human lymphocytes by the alkylating agent 2,2'-dichlorodiethyl sulfide (Sulfur mustard, HD) , Meier, H.L.;Johnson, J.B. , Toxicol. Appl. Pharmacol. / v.113,pp.234-239, 1992

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일