• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


LBD-001, a recombinant human interferon $\gamma$ produced by genetically engineered yeast as a host system, was intravenously administered to pregnant female rabbits (New Zealand White strain) from day 6 to 18 of gestation at dose levels of $0.35 \times 10^6$, $0. 69 \times 10^6$, and $1.38 \times 10^6$ I.U./kg/day. Hydrocortisone sodium succinate (0.3 mg/kg/day) was also given in the same way. Teratological effects of the test agents on the organogenesis of fetuses and the development of offsprings (F1 rabbits) were investigated. The results were as followings: (1) No significant changes by the treatment of LBD-001 or hydrocortisone sodium succinate were observed in the body weights, the food and water consumption, the lactating or nurshing behaviors, and the autopsy of the pregnant rabbits. (2) No significant changes in the resorption rate, the fetal organogenesis, and the normal develpoment of offsprings (F1) by the treatment of LBD-001 or hydrocortisone sodium succinate were detected. The results show that LBD-001 at the dose of $1.38 \times 10^6$ I.U./kg/day or less and hydrocortisone sodium succinate at the dose of 0.3 mg/kg/day are neither teratogenic in the organogensis of the fetuses and the development of the offsprings (F1) nor toxic to the mother rabbits.

참고문헌 (11)

  1. Teratological study of LBD-001, a recombinant interferon γ, in rats , Cho, S.I.;Lee, E.B. , J. Appl. Pharmacol / v.4,pp.301-309, 1996
  2. Studies of polyethylene glycol treated human immunoglobulin (GV-523), (3) Teratogenectity study in rabbits , Satoh, T.;Kaneko, Y.;Narama, I. , Pharmacometrics / v.27,pp.191-195, 1984
  3. Embryogical consideration in teratology; Methods for administering agents and detecting malformations in experimental animals , Wilson, J.G.;Wilson, J.G.(ed);Warkany J.(ed) , Teratology: Principles and Techniques / v.,pp.251-277, 1965
  4. Teratological studies on betamethasone 17-benzoate (MS-1112), Ⅱ. Teratogenecity and reproduction tests in rabbits , Ishimura, K.;Honda, Y.;Neda, K.;Ishikawa I.;Otawa, T.;Kawaguchi, Y.;Sato, H.;Henmi, Z. , Pharmacometrics / v.10,pp.685-694, 1975
  5. Shirasu, Y.;Matsuoka, O.;Shirasu, Y.(ed);matsuoka, O.(ed) , Environmental toxicology; Method and safety evaluation / v.,pp.281-332, 1981
  6. Fertility study of LBD-001, a recombinant human interferon γ, in rats , Lee, E.B.;Cho, S.I. , J. Appl. Pharmacol / v.4,pp.297-300, 1996
  7. National Institute of Safety Research of Korea , Toxicity test guidelines for drugs / v.,pp.36, 1986
  8. Induction of cleft palate in rabbits by several glucocorticoids , Walker, B.E. , Pro. Soc. Exp. Biol. Med. / v.125,pp.1281-1284, 1967
  9. A note on staining of the skeleton of cleared specimens with alizarin red S , Dawson, A.B. , Stain Technol / v.1,pp.123-125, 1926
  10. Test methods for assessing female reproductive and developmental toxicology , Manson, J.M.;Zenick, H.;Costlow, R.D.;Hayes, A., W.(eds) , Principles and Methods of Toxicology(3rd edition) / v.,pp.989-1037, 1994
  11. Reproduction studies of prednisolone 17-valproate 21-acetate (2) Teratological study in rabbits , Koga, T.;Ota, T.;Aoki, Y.;Suganuma, Y. , Pharmacometrics / v.20,pp.87-98, 1980

이 논문을 인용한 문헌 (1)

  1. 1997. "" 한국독성학회지 = The Korean journal of toxicology, 13(1): 175~182 


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일