• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


The elevation of intracellular calcium in various tissues due to oxidative stress induced by either menadione or adriamycin has been well documented. The increase of calcium level in platelets results in aggregation of platelets. To test the hypothesis that chemically induced calcium elevations can play a role in platelet aggregation, we have studied the effects of menadione and adriamycin on aggregation of platelets isolated from female rats. Treatment with menadione and adriamycin to platelet rich plasma (PRP) appeared to induce platelet aggregations up to 60%, as determined by aggregometry. However, exposure of PRP to rnenadione or adriamycin led to a loss of viability, as measured by lactate dehydrogenase (LDH) leakage. Morphological studies of platelets revealed that, when PRP was treated with menadione, aggregates of platelets were not observed and the numbers of platelets were decreased significantly. This suggests that menadione and adriamycin decreased turbidity by inducing platelet lysis rather than platelet aggregation. These cellular toxicities induced by menadione or adriamycin was not correlated with oxygen consumption rate but with depletion of protein thiols, suggesting that protein thiols might play an important role in chemical-induced platelet toxicity.

참고문헌 (27)

  1. Alteration in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes , Di Monte, D.;Ross, D.;Bellomo, G.;Eklow, L.;Orrenius, S. , Arch. Biochem. Biophys. / v.235,pp.334-342, 1984
  2. Redox cycling and sulfhydryl arylation: their relative importance in the mechanism of quienone cytotoxicity to isolated hepatocytes , Gant, T. W.;Rao, D. N. R.;Mason, R. P.;Cohen, G. M. , Chem. Biol. Interact. / v.65,pp.157-173, 1988
  3. Mechanisms of toxicity of naphthoquinones to isolated hepatocytes , Miller, M. G.;Rodgers, A.;Cohen, M. C. , Biochem. Pharmacol. / v.35,pp.1177-1184, 1985
  4. Comparison of the effects of redox cycling and arylating quinones on hepatobiliary function and glutathione homeostasis in rat hepatocyte couplets , Stone, V.;Coleman, R.;Chipman, J. K. , Toxicol. Appl. Pharmacol / v.138,pp.195-200, 1996
  5. Platelet-derived serotonin, the endothelium and cardiovascular disease , Vanhoutte, P.M. , J. Cardiovas. Pharmacol. / v.17,pp.6-12, 1991
  6. Modified smear method for screening potential inhibitors of platelet aggregation from plant sources , Yun, H.S.;Kim, S.O.;Kim, J.H.;Lee, J.R. , J. Nat. Prod. / v.48,pp.363-369, 1985
  7. Menadione-induced cyto-toxicity is associated with thiol oxidation and alteration in intracellular $Ca^{2+}$ homeostasis , Di Monte, D.;Bellomo, G.;Thor, H.;Nicotera, P.;Orrenius, S. , Arch. Biochem. Biophys. / v.235,pp.343-350, 1984
  8. Factors influencing platelet function : Adhesion, release and aggregation , Mustard, J.F.;Packman, M.A. , Pharmacol. Rev. / v.22,pp.97-187, 1979
  9. Platelets in hemostasis and thrombosis , Stormorken, H.;Holmsen, H.(ed.) , Platelet Responses and Metabolism / v.,pp.3-32, 1984
  10. Membrane depolarization inhibits thrombin-induced calcium influx and aggregation in human platelets , Kovacs, T.;Tordai, A.;Szasz, I.;Sarkadi, B.;Gardos, G. , FEBS Letter / v.266,pp.171-174, 1989
  11. Cytoplasmic free $Ca^{2+}$ in human platelets : $Ca^{2+}$ thresholds and $Ca^{2+}$-independent activation for shape change and secretion , Rink, T.J.;Smith, S.W.;Tsien, R.Y. , FEBS Letter / v.148,pp.21-26, 1982
  12. Disruption of mitochondrial calcium homeostasis following chronic doxorubicin administration , Solem, L.E.;Henry, T.R.;Wallace, K.B. , Toxicol. Appl. Pharmacol. / v.129,pp.214-222, 1994
  13. Mechanism of menadione-induced cytotoxicity in rat platelets , Kim, K. A.;Lee, J. Y.;Park, K. S.;Kim, M. J.;Chung, J. H. , Toxicol. Appl. Pharmacol / v.138,pp.12-19, 1996
  14. Increase of NAD(P)H:quinone reductase by dietary antioxidants: Possible role in protection against carcinogenesis and toxicity , Benson, A.M.;Hunkeler, M.J.;Talalay, P. , Proc. Natl. Acad. Sci. USA / v.77,pp.5216-5220, 1980
  15. Role of calcium ion in platelet serotonin uptake regulation , Nishio, H.;Nezasa, K.;Nakata, Y. , Eur. J. Pharmacol. / v.288,pp.149-155, 1995
  16. Measurement of ionized calcium in blood platelet with the photoprotein aequorin: Comparison with quin2 , Johnson, P.C.;Ware, J.A.;Clivden, P.B.;Smith, M.;Pvorak, A.M.;Salzman, E.W. , J. Biol. Chem. / v.260,pp.2069-2076, 1985
  17. Thompson, A.R.;Harker, L.A. , Manual of Hemostasis and Thrombosis / v.,pp., 1987
  18. Calcium-mediated mechanisms in chemically induced cell death , Nicotera, P.;Bellomo, G.;Orrenius, S. , Ann. Rev. Pharmacol. Toxicol. / v.32,pp.449-470, 1992
  19. Calcium homeostasis in unstimulated platelet , Brass L.F. , J. Biol. Chem. / v.259,pp.12563-12570, 1984
  20. Lactate dehydrogenase , Bergmeyer, H.U.;Bernt, E.;Hess, B.;H.U.Bergmeyer , Methods in Enzymatic Analysis / v.,pp.736, 1965
  21. Human platelet size, shape and related functions in health and disease , Frojmovic, M.M.;Milton, J.C. , Physiol. Rev. / v.62,pp.185-261, 1982
  22. The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes , Ross, D.;Thor, H.;Threadgill, M. D.;Sandy, M. S.;Smith, M. T.;Moldeus, P.;Orrenius, S. , Arch. Biochem. Biophys. / v.248,pp.460-466, 1986
  23. The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes , Thor, H.;Smith, M.T.;Hartzell, P.;Bellomo, G.;Jewell, S.A.;Orrenius, S. , J. Biol. Chem. / v.257,pp.12419-12425, 1982
  24. Contemporary issues in toxicology : Quinone chemistry and toxicity , Monks, T.J.;Hanzlik, R.P.;Cohen, G.M.;Ross, D.;Graham, D.G. , Toxicol. Appl. Pharmacol. / v.112,pp.2-16, 1992
  25. Molecular mechanisms of platelet activation , Siess, W. , Physiol. Rev. / v.69,pp.123-143, 1989
  26. Calcium signaling in human platelets , Rink, T.J.;Sage, S.O. , Ann. Rev. Physiol. / v.52,pp.431-439, 1990
  27. Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones , Doroshow, J.H. , Proc. Natl. Acad. Sci. USA / v.83,pp.4514-4518, 1986

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일