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논문 상세정보

랫드에 있어서 주야 시차가 Bromobenzene 대사에 미치는 영향

Effect of Circadian Rhythms on the Bromobenzene Metabolism in Rats

Abstract

To investigate the circadian variation in the bromobenzene metabolism, bromobenzene(400 mg/kg body weight) was intraperitoneally administered to the rats every other day for 6 days both in the night; 24:00 and the day; 12:00. Each group of animals was sacrificed at 8hr after last injection of bromobenzene. The contents of hepatic CYP were more increased in control rats of night phase than those of day phase but in case of bromobenzene treatment there were no differences in hepatic CYP between rats of the night phase and those of day phase and the injection of prednisolon inhibited the hepatic CYP content in rats. Furthermore, the decreasing rate of hepatic glutathione contents to the control was higher in rats of day phase than those of night phase by the bromobenzene treatment. And the hepatic glutathione S-transferase activities were increased both in control and bromobenzene treated rats of the night phase than those of day phase. On the other hand, liver weight per body weight(%), hepatic lipid peroxide content, serum levels of alanine aminotransferase were more increased both in bromobenzene-treated and control rats of the night phase than those in the day phase. These results indicate that the rats of night phase may induce more accelerated formation of bromobenzene 3,4-oxide from bromobezene than those of day phase in rats.

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참고문헌 (30)

  1. The role of glutathione and glutathione S-transferase in mercapturic acid biosynthesis , Boyland, E.;Chasseud, L. F. , Advances in Enzyme Regulation / v.32,pp.173-219, 1969
  2. Diurnal variations in the transferase and hydrolases involved in glucuronide and sulfate conjugation of rat liver , Belanger, P. M.;Lalande, M.;Labrecque, G.;Dor, F. , Drug Metabol. Dispo. / v.13,pp.386-389, 1985
  3. Bloom, W.;Fawcett, D. W. , A Textbook of Histology (10th ed.) / v.,pp., 1975
  4. Response of glutathione peroxidase to dietary selenium in rats , Chow, C. K.;Tappel, A. L. , Journal of Nutrition / v.104,pp.444-451, 1974
  5. Tissue sulfhydryl group , Ellman, G. L. , Archieves of Biochemistry and Biophysics / v.82,pp.70-77, 1959
  6. Susceptibility to ouabain and physiological 24-hour periodicity , Halberg, F.;Haus, E.;Stephens, A. , Federal Process / v.18,pp.63, 1959
  7. Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation , Martin, J. P.;Dailey, M.;Sugarman, E. , Archieves of Biochemistry and Biophysics / v.255,pp.329-336, 1987
  8. Day-night periodicity in phenobarbital response of mice and influence of sociopsychological conditions , Davis, W. M. , Experentia / v.18,pp.235-237, 1962
  9. The carbon monoxidebinding pigment of liver microsomes-Evidence for its hemoprotein nature , Omura, T.;Sato, R. , Journal of Biological Chemistry / v.239,pp.2370-2378, 1964
  10. A note on the spectrophotometer assay of glutamic oxaloacetic transminase in human blood serum , Karmen, A. , Journal of Clinical Investigation / v.34,pp.131-133, 1955
  11. Protein measurement with folin phenol reagent , Lowry, O. H.;Rosebrough, N. J.;Farr, A. L.;Randall, R. L. , Journal of Biological Chemistry / v.193,pp.265-275, 1951
  12. Premercapturic acid metabolites of bromobenzene derived via its 2,3- and 3,4-oxide metabolites , Zheng, J.;Hanzlik, R. P. , Xenobiotica / v.21,pp.535-546, 1991
  13. Browning, E. , Toxicology and Metabolism of Industrial Solvents / v.,pp., 1955
  14. Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction , Ohkawa, H.;Ohish, N.;Yaki, K. , Analytical Biochemistry / v.95,pp.351-355, 1979
  15. Circadian periodicity in susceptibility to lidocaine hydrochloride , Lutsch, E. F.;Morris, R. W. , Science / v.156,pp.100-102, 1967
  16. Schefler, W. C. , Statistics for the Biological Sciences / v.,pp., 1980
  17. Sex difference in testing pituitary-adrenal function in the rat , Critchlow, V.;Liebelt, R. A.;Bar-Sela, M.;Mountcastle, W.;Lipscomb, H. S. , American Journal of Physiology / v.205,pp.807-, 1963
  18. Glutathione S-transferase, The first enzymatic step in mercapturic acid formation , Habig, W. H.;Pabist, M. J.;Jakoby, W. B. , Journal of Biological Chemistry / v.249,pp.7130-7139, 1974
  19. Reinberg, A.;Smolensky, S. , Biological Rhythms and Medicine / v.,pp., 1957
  20. Possible mechanism of liver necrosis caused by aromatic orgnic compounds , Brodie, B. B.;Reid, W. D.;Cho, A. K.;Sipes, G.;Krishna, G.;Gillette, J. R. , Proc. Nat. Acad. Sci., USA. / v.68,pp.160-164, 1971
  21. Aspects of free radical reation in biological system , Leiborvitz, B. E.;Siegel, B. V. , Journal of Gerontology / v.35,pp.45-56, 1980
  22. Studies on the quantitative qualitative characterization of erythrocytes glutathione peroxidase , Peglia, E. D.;Valentine, W. N. , Journal of Laboratory and Clinical Medicine / v.70,pp.158-169, 1967
  23. Bromobenzene metabolism and hepatic necrosis , Ried, W. D.;Christie, B.;Krishna, G.;Mitchell, J. R.;Moskowitz, J.;Brodle, B. B. , Pharmacology / v.6,pp.41-55, 1971
  24. Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetycysteine and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes , Thor, H.;Moldeus, P.;Orrenius, S. , Archives of Biochemistry and Biophysics / v.192,pp.405-413, 1979
  25. Protective effect of diallyl disulfide on the bromobenzene induced hepatotoxicity in mice , Lee, S. I.;Yoon, C. G.;Huh, K. , Korean Journal of Pharmacology / v.26,pp.185-192, 1990
  26. Effect of starvation on NADPH- dependent enzymes in liver microsomes of male and female rats , Kato, R.;Gillette, J. R. , Journal of Pharmacology and Experimental Therapeutics / v.150,pp.279-284, 1965
  27. Circadian susceptibility rhythm of mice to librium , Marte, E.;F. Halberg , Federal Process / v.20,pp.305, 1961
  28. 사염화탄소를 투여한 흰쥐에서의 간장 및 혈청 xanthine oxidase 활성의 변동 , 윤종국 , 과학논집 / v.6,pp.75-82, 1980
  29. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase , Reitman, S.;Frankel, S. , American Journal of Clinical Pathology / v.28,pp.50-63, 1957
  30. Daily rhythmic variation in hepatic drug metabolism in the rat and mouse , Radzialowski, F. M.;Bousquet, W. F. , Journal of Pharmacology and Experimental Therapeutics / v.163,pp.229-238, 1968

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