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논문 상세정보

비타민 E 보강식이가 KK 마우스에서 지질과산화물과 신장 항산화계 효소 활성도에 미치는 영향

Effects of Vitamin E Supplementation on Lipid Persoxides and Renal Antioxidative Enzyme Activities in KK Mice

Abstract

We investigated the effects of vitamin E supplementation on lipid peroxidation and on the activities of antioxidative enzymes in kidney of KK mice of various age and duration of diabetes. Weaned KK mice were fed high fat a diet containing 20% corn oil(wt/wt), and were sacrificed at 4, 6, and 9 months of age. The high vitamin E diet consisted of the high fat diet supplemented with an excessive amount of dl-$\alpha$-tocopheryl acetate (2080 IU/kg diet) . In the diabetic groups, we found an increase in lipofuscin and decrease in antioxidative enzyme activities with aging. Treatment with vitamin E did not modify the level of fasting blood glucose. However, a significant decrease in lipofuscin and increase in antioxidative enzyme acitvities were observed in diabetic mice.

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이 논문을 인용한 문헌 (1)

  1. 1999. "Effects of Antioxidant Vitamins Supplementation on Antioxidative Status and Plasma Lipid Profile in Korean NIDDM Patients" 韓國營養學會誌 = The Korean journal of nutrition., 32(7): 775~780 

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