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흡연이 혈장의 비타민 C 함량과 지질과산화 및 지질의 농도 변화에 미치는 영향

Changes of Vitamin C Level , Lipid Peroxidation and Lipid Concentration in Plasma of Smokers and Non-smokers

Abstract

Cigarette smoking is a major risk factor of atherosclerosis and has been reported to contain an abundance of free radical species which could be expected to deplete antioxidants such as vitamin C . The present study was designed to investigate the relationship between smoking, plasma lipid and lipoprotein concentration, and plasma vitamin C level. Fifty-five healthy male smokers and 32 non-smokers were investigated in the study. Mean age, body weight , BMI and blood pressure made no differences in both smokers and non-smokers. Significantly, smokers has higher plasma total cholesterol and LDL-C , and lower HDL-C /LDL-C ratio compared with non-smokers. Plasma level of thiobartiturin acid reactive substances(TBARS), indicator of lipid peroxidation and increased susceptibility of LDL towards lipid perosidation, were elevated in smokers(p<0.001), while the plasma vitamin C level of smokers was significantly lower than that of non-smokers(p<0.05), indicating that elevated lipid peroxidation are associated with decreased plasma vitamin C content. In non-smokers a significantly positive correlation was observed between dietary vitamin C intake and plasma levels, but no such association observed in smokers. Lack of such a relationship and the decreased plasma vitamin C level in the smokers suggest that smoking may cause increased turnover of the plasma antioxidant. Consuquently, the sustained free radical load derived from smoking causes an imbalance in oxidant/antioxidant status and it could be expected that cigarette smoking renders plasma LDL more susceptible to oxidative modification . In the present study the possible explanations for that cigarette smokers have a higher risk of cardiovascular disease include the changes of blood lipid and lipoprotein concentration, and plasma vitamin C status which might have protective functions against free radicals -medaited lipid peroxidation.

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이 논문을 인용한 문헌 (5)

  1. 1998. "Effects of Vitamin C Supplementation on Immune Status in Smoking and Nonsmoking Male College Students" 韓國營養學會誌 = The Korean journal of nutrition., 31(8): 1244~1253 
  2. 1998. "The Relation of the Elevated Plasma Lipid Levels to Plasma Vitamin E Status and Activities of Erythrocyte Glutathione Perosicase in Smokers" 韓國營養學會誌 = The Korean journal of nutrition., 31(8): 1254~1262 
  3. 2000. "Effects of Smoking and Regular Physical Exercise Habits on the Status of Plasma Lipidsoluble Antioxidant Vitamins and Ubiquinone(Coenzyme Q10) in Korean Middle-aged Men" 韓國營養學會誌 = The Korean journal of nutrition., 33(2): 158~166 
  4. 2001. "Effect of Life Style and Dietary Factors on Plasma Total Radical-Trapping Antioxidant Potential (TRAP) in Korea Adult" 韓國營養學會誌 = The Korean journal of nutrition., 34(7): 762~769 
  5. 2003. "Comparison of Nutrient Intakes and Serum Mineral Levels between Smokers and Non-Smokers" 韓國營養學會誌 = The Korean journal of nutrition., 36(6): 635~645 

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