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Abstract ▼ AI-Helper

Background : Idebenone(CV-2619) is a synthetic chemical of benzoquinone derivative. It has been known to improve the physical, emotional and behavioral problems due to stroke. A single blind study was performed to assess the usefulness and safety of Idebenone in the treatment of patients with cerebr...

Background : Idebenone(CV-2619) is a synthetic chemical of benzoquinone derivative. It has been known to improve the physical, emotional and behavioral problems due to stroke. A single blind study was performed to assess the usefulness and safety of Idebenone in the treatment of patients with cerebral atherosclerosis and sequelae of cerebral infarction. Method : The effect and safety of Idebenone was investigated in 74 patients with symptoms of cerebral atherosclerosis (N=61) or sequelae of cerebral infarction (N=13). The patients were randomized to the Idebenone or the placebo group, which did not show any significant differences in the clinical characteristics. Clinical assessment was performed by using the check-list of comprehensive symptom groups before the trial of Idebenone and 4th 8th week after initiating the Idebenone or the placebo. Results : Forty one patients of the experimental group were treated with Idebenone and 33 of the control group with placebo. After 8 weeks, the Idebenone cup and the place group showed clinical improvement (Score 2) in 85% and 19% respectively. In 49% of the Idebenone group, there was more marked improvement (Score 3) in overall usefulness. In comparison to the placebo group, the Idebenone group experienced significant decrease in the severity of subjective symptoms and emotional problems (p<0.05). There showed the adverse effects of dizziness and skin rash in the Idebenone group. They were not serious and immediately disappeared after stopping the administration of Idebenone without any sequelae. Conclusion : We conclude that Idebenone can be used as an effective and safe agent to improve neurobehavioral complications in chronic cerebral atherosclerosis and infarction patients.

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