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Background: Many therapeutic trials for chronic liver diseases have been performed, however, the effects are still controversial. To evaluate the effect of colchicine in the patients of chronic liver diseases, we observed the changes of the clinical laboratory test variables, including albumin (Alb)...

Background: Many therapeutic trials for chronic liver diseases have been performed, however, the effects are still controversial. To evaluate the effect of colchicine in the patients of chronic liver diseases, we observed the changes of the clinical laboratory test variables, including albumin (Alb), bilirubin (BR), ALT, AST, cholesterol, and prothrombin time (PT), which are indirectly used to show the functional status of liver. Methods : We retrospectively analyzed the first and last laboratory test variables obtained from 73 colchicine groupand 61 non-colchicine group, which were followed-up for more than 2 years. The two groups were compared with the X value ; Multiple logistic regression analysis was performed on the clinical laboratory test variables obtained at the time of liver biopsy, which gave us a statistically meaningful equation. $[Z=10.0756-0.9418{\times}Alb+0.4791{\times}BR-0.0640{\times}PT,\;X=e^z/(e^z+1)$, as the X value increases from 0 to 1, chronic active hepatitis will progress into liver cirrhosis] Results : In mild and moderate chronic active hepatitis groups, improvements were noticed in both colchicine treated and non-treated groups, however, there was no statistical difference. (41.9% vs 46.4%) In severe chronic active hepatitis and liver cirrhosis (Child-Pugh A) groups, we could notice an improvment in colchine group. On the other hand, the non-colchicine group showed progressive worsening, which was statistically meaningful(51.4 % vs 25.8%) (p<0.05) Conclusion : Colchicine may prevent the progression of chronic liver disease, especially, in severe chronic active hepatitis and early cirrhotic patients without significant side effects. And this results also suggest that the stage of the progression in chronic liver disease would be important for colchicine treatment.

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