Matubara, H.
(Nippon Paint Co. Ltd.)
,
Miharu, K.
(Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy)
,
Kinoshita, K.
(Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy)
,
Koyama, K.
(Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy)
,
Ye, Yang
(Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy)
,
Takahashi, K.
(Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy)
,
Yoshimura, I.
(Kochi Gakuen College)
,
Yamamoto, Y.
(Nippon Paint Co. Ltd.)
,
Miura, Y.
(Nippon Paint Co. Ltd.)
,
Kinoshita, Y.
(Nippon Paint Co. Ltd.)
The analogues of lichen components showing anti-tyrosinase activities were synthesized. 4-Alkylresorcinol derivatives showed both the inhibitory activity and cytotoxicity in B-16 melanoma cells at the doses of 10 mM to 1.2 mM. Resorcinol and 4-methylresorcinol showed the inhibitory effect with a low...
The analogues of lichen components showing anti-tyrosinase activities were synthesized. 4-Alkylresorcinol derivatives showed both the inhibitory activity and cytotoxicity in B-16 melanoma cells at the doses of 10 mM to 1.2 mM. Resorcinol and 4-methylresorcinol showed the inhibitory effect with a low cytotoxicity at the doses of 2.5 mM and $600\;{\mu}M$ among 4-alkylresorcinols, respectively. Some diphenylmethane derivatives (Type A, B, and C) had strong activities with a low cytotoxicity. While xanthine derivatives had no effect. Glucosides of 4,5-alkylresorcinol and the diphenylmethane derivative (Type B) were prepared to decrease the cytotoxicity. As a result, no effect were observed. Liposome of the diphenylmethane derivative (Type B) was prepared for the same purpose, and the latter showed a remarkable effect at the dose of $15\;{\mu}M$ with a low cytotoxicity.
The analogues of lichen components showing anti-tyrosinase activities were synthesized. 4-Alkylresorcinol derivatives showed both the inhibitory activity and cytotoxicity in B-16 melanoma cells at the doses of 10 mM to 1.2 mM. Resorcinol and 4-methylresorcinol showed the inhibitory effect with a low cytotoxicity at the doses of 2.5 mM and $600\;{\mu}M$ among 4-alkylresorcinols, respectively. Some diphenylmethane derivatives (Type A, B, and C) had strong activities with a low cytotoxicity. While xanthine derivatives had no effect. Glucosides of 4,5-alkylresorcinol and the diphenylmethane derivative (Type B) were prepared to decrease the cytotoxicity. As a result, no effect were observed. Liposome of the diphenylmethane derivative (Type B) was prepared for the same purpose, and the latter showed a remarkable effect at the dose of $15\;{\mu}M$ with a low cytotoxicity.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.