$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

비타민 E와 비타민 C 첨가가 Scopolamine에 의한 인지능력 감퇴에 미치는 영향

Effects of Vitamin E and Vitamin C Supplementation on the Decrease in Cognitive Function Induced by Scopolamin

Abstract

With the increasing elderly population in Korea, dementia has become a mojor health problem in Korea. Several studies have been conducted on the association between dementia and dietary intake, especially vitamin E and vitamin C. The purpose of this study was to investigate the effect of vitamin E and vitamin C supplementation on the decrease in cognitive function induced by scopolamine(300mg/kg) in rats. Rats were divided into three groups : control, vitamin C, and vitamin E supplementation(2.4g Vit C or Vit E /100g diet) and fed the diets for 6 weeks. There were significant decreases in active avoidance response and brain acetylcholinesterase activity in the control group, but no significant differences were observed in the vitamin E and C groups after scopolamine treatment. Brain dopamine concentration of vitamin E and C groups was significantly higher than those of control group after scopolamine injection. The concentrations of brain norepinephrine also showed similar tendence, even though it was not statistically significant. These results indicate that vitamin E and vitamin C may protect against the cognitive function decrease induced by scopolamine. However, it is still unclear how vitamin E and C influence brain neurotransmitters and improve cognitive function. Further study is need to elucidate the role of vitamin E and C supplementation in the prevention of dementia.

저자의 다른 논문

참고문헌 (55)

  1. Kim SH;Yoo CH;Kim SH;Lee SS;Kang MH;Chang NS , Family nutritional -Daewoo science library-. / v.,pp., 1996
  2. Nutritional factors in physical and cognitive function of elderly people , Rosenberg IH;Miller JW , Am J Clin Nutr / v.55,pp.1237S-1243S, 1992
  3. The possible role of peroxynitrite in Alzheimer's disease : A simple hypothsis that could be tested more thoroughly , Van Dyke K , Medical Hypotheses / v.48,pp.375-380, 1997
  4. A new and rapid colorimetric determination of acetylcholinesterase activity , Ellman GL;Courtney D;Andres V Jr;Featherstone RM , Biochemical Pharmacology / v.7,pp.88-95, 1961
  5. A double-blind, placebo-controlled multicenter study of Tacrine for Alzheimer's disease , Davis KL;Thal LJ;Gamzu ER;Davis CS;Woolson RF;Gracon SI;Drachman DA;Schneider LS;Whitehouse PJ;Hoover TM;Morris JC;Kawas CH;Knopman DS;Earl NL;Kumar V;Doody RS , N Engl J Med / v.327,pp.1253-1259, 1992
  6. Experimental techniques for developing new drugs acting on dementia -Alzheimer's disease animal model induced by beta-amyloid protein , Nitta A;Nabeshima T , Nihon Shinkei Seishin Yakurigaku Zasshi / v.16,pp.85-90, 1996
  7. The vitamins , Gerald F;Combs JR , Fundamental aspects in nutrition and health / v.,pp., 1991
  8. Plasma concentrations of vitamin A and E and carotenoids in Alzheimer's disease , Zaman Z;Roche S;Fielden P;Frost PG;Niriella DC;Cayley ACD , Age Aging / v.21,pp.91-94, 1992
  9. Association between nutritional status and cognitive functioning in a healthy population , Goodwin JS;Good JM;Gerry PJ , JAMA / v.249,pp.2917-2921, 1983
  10. Handbook of vitamins , Lawrence JM , Nutritional, biochemical, and clinical aspects / v.,pp., 1984
  11. Kim SH;Kim WY , Aging-Daewoo science library-. / v.,pp., 1995
  12. Pharmacological evaluation of novel Alzheimer's disease therapeutics : Acetylcholinesterase inhibitors related to galanthamine , Bores GM;Huger FP;Petko W;Mutlib AE;Camacho F;Rush DK;Selk DE;Wolf V;Kosley RW JR;Davis L;Vargas HM , Journal of Pharmacology & Experimental Therapeutics / v.277,pp.728-738, 1996
  13. Dietary intakes and nutritional status of old people with dementia living at home in Oslo , Nes M;Sem SW;Rousseau B;Bjorneboe GEA;Engedal K;Trygg K;Pedersen JI , Europ J Clin Nutr / v.42,pp.581-593, 1988
  14. Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease , Iyo M;Namba H;Fukushi K;Shinotoh H;Nagatsuka S;Suhara T;Sudo Y;Suzuki K;Irie T , Lancet / v.349,pp.1805-1809, 1997
  15. Lipid peroxidation and free radical scavengers in Alzheimer's disease , Jeandel C;Nicolas MB;Dubois F;Nabet-Belleville F;Penin F;Cuny G , Gerontology / v.35,pp.275-282, 1989
  16. Clinical significance of cognitive performance by hypertensive patients , Elias MF;Robbins MA;Schultz NR;Streeten DH;Elias PK , Hypertension / v.9,pp.192-197, 1987
  17. Cho IH , SAS and statistics consulting / v.,pp., 1993
  18. Neurotransmitter-related enzymes in senile dementia of the Alzheimer type , Davis P , Brain Res / v.171,pp.319-327, 1979
  19. Influence of dietary linolenic acid/linoleic acid ratio on brain lipid composition and acetylcholinesterase activity in different aged rat , Yoon GA , Kor J Nutr / v.28,pp.706-716, 1995
  20. Board of Statistics. , Future estimation of population / v.,pp., 1991
  21. A study on the realtion between dietary intake and cognitive function in the elderly , Park SO;Han SS;Ko YS;Kim YJ;Lee HS;Kang NE;Lee JH;Kim WK;Kim SH , Kor J Diet Cult / v.7,pp.149-155, 1992
  22. Plasma catechols and monoamine oxidase metabolites in untreated Parkinson's and Alzheimer's diseases , Ahlskog JE;Uitti RJ;Tyce GM;O'Brien JF;Petersen RC;Kokmen E , J Neurol Sci / v.136,pp.162-168, 1996
  23. Effect of DHA and environmental enrichment on brain fatty acid composition and acetylcholinesterase activity , Kim MJ;Kim SH , Kor J Nutr / v.29,pp.32-40, 1996
  24. Laboratory examinations correlated with severity of dementia , Oishi M;Mochizuki Y;Yoshihashi H;Takasu T;Nakano E , Annals of Clinical & Laboratory Science / v.26,pp.340-345, 1996
  25. Harvey AL , Natural and Synthetic Neurotoxins / v.,pp., 1993
  26. Binstock RH;Post SG;Whitehouse PJ , Dementia and Aging -Ethics, Values, and Policy Choices-. / v.,pp., 1992
  27. Concentrations of gamma-tocopherol and its quinone derivative in cerebrospinal fluid from patients with vascular dementia of the Binswanger type and Alzheimer type dementia , Tohgi H;Abe T;Nakanishi M;Hamato F;Sasaki K;Takahashi S , Nueroscience Letter / v.174,pp.73-76, 1994
  28. Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus , Chapman CA;Yeomans JS;Blaha CD;Blackburn JR , Neuroscience / v.76,pp.177-186, 1997
  29. Ascorbic acid in cerebrospinal fluid -A possible protection against free radicals in the brain , Barabas J;Nagy E;Degrell I , Arch Gerontol Geriatr / v.21,pp.43-48, 1995
  30. Metrifonate improves spatial navigation and avoidance behavior in scopolamine-treated, medial septum-lesioned and aged rats , Riekkinen P Jr;Schmidt B;Stefanski R;Kuitunen J;Riekkinen M , Europ J Pharm / v.309,pp.121-130, 1996
  31. The effects of ascorbic acid and oxiracetam on scopolamine-induced amnesia in a habituation test in aged mice , de Angelis L;Furlan C , Neurobiology of Learning & Memory / v.64,pp.119-124, 1995
  32. Gruetzner H , Alzheimer's-A caregiver's guide and sourcebook-. / v.,pp., 1988
  33. Noradrenergic DSP-4 lesions aggravate impairment of working memory produced by hippocampal muscarinic blockade in rats , Ohno M;Yoshimatsu A;Kobayashi M;Watanabe S , Pharmacology Biochemistry & Behavior / v.57,pp.257-261, 1997
  34. Therapy options in Alzheimer's disease , Gottfries CG , Br J Clin Practice / v.48,pp.327-330, 1994
  35. Plasma 3-methoxy-4-hydroxyphenylglycol(MHPG) and clinical symptoms in Alzheimer's disease , Lawlor BA;Bierer LM;Ryan TM;Schmeidler J;Knott PJ;Williams LL;Mohs RC;Davis KL , Biological Psychiatry / v.38,pp.185-188, 1995
  36. The role of brain noradrenaline in cortical activation and behavior : A study of lesions of the locus coeruleus, medial thalamus and hippocampusneocortex and of muscarinic blockade in the rat , Vanderwolf CH;Baker GB , Behavioural Brain Research / v.78,pp.225-234, 1996
  37. The significance of the activity of CSF cholinesterases in dementias , Shen ZX , Medical Hypothesis / v.47,pp.363-376, 1996
  38. Nutritional status and cognitive functioning in a normally aging smaple : A6-y reassessment , Rue AL;Koehler KM;Wayne SJ;Chiulli SJ;Haaland KY;Garry PJ , Am J Clin Nutr / v.65,pp.20-29, 1997
  39. Posatirelin for the treatment of late-onset Alzheimer's disease : A double blind multicentre study vs citicoline and ascorbic acid , Parnetti L;Ambrosoli L;Abate G;Azzini C;Balestreri R;Barotorelli L;Bordin A;Crepaldi G;Cristianini G;Cucinotta D;Cuzzupoli M;De Candia O;Fabris F;Maggioni M;Scarpa R;Villardita C;Girardello R;Poli A;Senin U , Acta Neurol Scand / v.92,pp.135-140, 1995
  40. Effect of Hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain , Hirokawa S;Nose M;Ishige A;Amagaya S;Oyama T;Ogihara Y , J Ethnopharmacology / v.50,pp.77-84, 1996
  41. Regulatory effect of danggui-shaoyaosan on central cholinergic nervous system dysfunction in mice , Itoh T;Michijiri S;Murai S;Saito H;Nakamura K;Itsukaichi O;Fujiwara H;Ookubo N;Saito H , Am J Chinese Med / v.24,pp.205-217, 1996
  42. Rapid automated analysis of biogenic amines and their metabolites using reversed-phase high performance liquid chromatography with electrochemical detection , Saller CF;Salama AI , J Chrom / v.309,pp.287-298, 1984
  43. A controlled trial of Tacrine in Alzheimer's disease , Farlow M;Gracon SI;Hershey LA;Lewis KW;Sadowsky CH;Dolan-Ureno J , JAMA / v.268,pp.2523-2529, 1992
  44. Dopamine mediates the light-evoked suppression of serotonin N-acetyltransferase activity in retina , Iuvone PM;Boatright JH;Bloom MM , Brain Res / v.418,pp.314-324, 1987
  45. Assessment of dopamine metabolism in brain of patients with dementia by means of 18F-fluorodopa and PET , Itoh M Meguro K;Fujiwara T;Hatazawa J;Iwata R;Ishiwata K;Takahashi T;Ido T;Sasaki H , Ann Nucl Med / v.8,pp.245-251, 1994
  46. Biochemistry and molecular biology of dementia , Suh Y , Kor J Psychopharmacol / v.3,pp.13-21, 1992
  47. Variables associated with cognitive function in elderly California seventhday adventists , Raser GE;Singh PN;Bennett H , Am J Epidemiol / v.143,pp.1181-1190, 1996
  48. Dietary influences on the Synthesis of Neurotransmitters in the brain , Growdon JH;Wurtman RJ , Nutrition Reviews / v.37,pp.129-136, 1979
  49. A controlled trial of selegilline, alpha-tocopherol, of both as treatment for Alzheimer's disease. The Alzheimer's disease cooperative study , Sano M;Ernesto C;Thomas RG;Klauber MR;Schafer K;Grudman M;Woodbury P;Growdon J;Cotman CW;Pfeiffer E;Schneider LS;Thal LJ , N Engl J Med / v.336,pp.1216-1222, 1997
  50. Cholinergic learning deficits in the marmoset produced by scopolamine and 1CV hemicholinium , Ridley BM;Barratt NG;Baker HF , Psychopharmacology / v.83,pp.340-345, 1984
  51. Neurochemical characteristics of early and late onset types of Alzheimer's disease , Rossor MN;Iversen Ll;Reynolds GP;Mountjoy CQ;Roth M , Br Med J / v.288,pp.961-964, 1994
  52. Autonomic dysfunction in patients with dementia of the Alzheimer type , Vitiello B;Veith RC;Molchan Se;Martinez RA;Lawlor BA;Radcliffe J;Hill JL;Sunderland T , Biological Psychiatry / v.34,pp.428-433, 1993
  53. Influence of education and occupation on the incidence of Alzheimer's disease , Stern Y;Gurland B;Tatamichi TK;Tang MX;Wilder D;Mayeux R , JAMA / v.271,pp.1004-1010, 1994
  54. Biochemical study on Alzheimer's disease(I) , Kang SY;Kim SH;Kim TG;Jung KK;Ko HS;Huh YB;Lee SD;Lee YK , The annual report of KFDA / v.1,pp.497-503, 1996
  55. A 30-week randomized controlled trial of high-dose Tacrine in patients with Alzheimer's disease , Knapp MJ;Knopman DS;Solomon PR;Pendlebury WW;Davis CS;Gracon SI , JAMA / v.271,pp.985-991, 0000

이 논문을 인용한 문헌 (1)

  1. 2000. "The Role of Vitamin C and Vitamin E Supplementation on Iron Contents and Biomarkers of Oxidative Stress in Blood, Liver and Brain of Aging Rats" 韓國營養學會誌 = The Korean journal of nutrition., 33(5): 507~516 

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일