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생기액(生肌液)의 세포독성 및 자궁경부암 바이러스 (HPV 16 type) 암 유발인자 E6와 E7의 작용에 미치는 효과

The Effects of Somatid on the Cytotoxicity of Cancer Cells and Human Papillomavirus Type 16 E6 and E7 Oncogenes

약학회지 = Yakhak hoeji v.44 no.4 , 2000년, pp.340 - 346  
Abstract

Cervical cancer is one of the leading causes of female death from cancer worldwide with about 500,000 deaths per year. A strong association between certain human papilloma viruses (HPV types 16 and 18) and cervical cancer has been well known. An extract of natural products, named as Somatid, has been used to investigate whether this agent has the ability of inhibiting the oncogenes E6 and E7 of HPV type 16. This Somatid inhibited the proliferation of human cervical cancer cell lines (C-33A, SiHa, CaSki) and HaCaT keratinocytes in a dose response manner, In vitro binding assay and ELISA showed that Somatid inhibited the in vitro biding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53. In addition, Somatid inhibited the in vitro binding of E7 and Rb which is essential tumor suppressor for the control of cell cycle. The levels of mRNA for E6 and E7 were also decreased by Somatid. Our data suggested that Somatid inhibited the oncogenecity of E6 and E7 of HPV 16 type, thus can be used as a putative anti-HPV agent for the treatment of cervical carcinomas caused by HPV.

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참고문헌 (16)

  1. Development of screening systems for drugs against human papillomvirus-associated cervical cancer;based on E6-E6-AP binding , Cho, Y.S.;Cho, C.W.;Joung, O.;Lee, K.A.;Park, S.N.;Yoon, D.Y. , Antiviral Res. / v.,pp., 2000
  2. Potential Drugs Against Cervical Cancer;Zinc-Ejecting Inhibitors of the Human Papillomavirus Type 16 E6 Oncoprotein , Beerheide, W.;Bernard, H.U.;Tan, Y.J.;Ganesan, A.;Rice, W.G.;Ting, A.E. , J. Natl. Cancer Institute / v.91,pp.1211, 1999
  3. 李時珍(著) , 圖解本草綱目 / v.,pp., 1987
  4. Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection , Woodworth, C.D.;Cheng, S.;Simpson, S.;Hamacher, L.;Chow, L.T.;Broker, T.R.;Dipaolo, J.A. , Oncogene / v.7,pp.619, 1992
  5. Hepatitis B virus transcriptional activators;mechanisms and possible role in oncogenesis , Henkler, F.F.;Koshy, R. , J. Viral Hepat. / v.3,pp.109, 1996
  6. Cell cycle models for molecular biology and molecular oncology;exploring new dimensions , Shackney, S.E.;Shankey, T.V. , Cytometry / v.35,pp.97, 1999
  7. Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products , Marchuk, D.;Drumm, M.;Saulino, A.;Collins, F.S. , Nucleic Acids Res. / v.19,pp.1154, 1990
  8. Human papillomavirus E6 and E7;proteins which deregulate the cell cycle , Tomasino, M.;Crawford, L. , Bioessays / v.17,pp.509, 1995
  9. The level of tyrosine kinase activity regulates the expression of p21/WAF1 in cancer cells , Reddy, K.B.;Deshamouni, V.G.;Chen, Y.Q. , Int J. Oncol. / v.15,pp.301, 1999
  10. Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines , Isfort, R.J.;Cody, D.B.;Lovell, G.;Doersen, C.J. , Mol. Carcinog. / v.14,pp.170, 1905
  11. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines , Scheffner, M.;Munger, K.;Byrne, J.C.;Howley, P.M. , Proc. Natl. Acad. Sci. / v.88,pp.5523, 1991
  12. The human papillomavirus E6/E7 genes induce discordant changes in the expression of cell growth regulatory proteins , Pei, X.F. , Carcinogenesis / v.17,pp.1395, 1996
  13. LMP1 of epstein-barr virus induces proliferation of primary mouse embryonic fibroblasts and cooperatively transforms the cells with a p16-insensitive CDK4 oncogene , Yang, X.;Sham, J.S.;Ng, M.H.;Taso, S.W.;Zhang, D.;S.W.L; Cao, L. , J. Virol. / v.74,pp.883, 2000
  14. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product , Dyson, N.;Howley, P.M.;Munger, K.;Harlow, E. , Science / v.243,pp.934, 1989
  15. Viral oncogenes accelerate conversion to immortality of cultured conditionally immortal human mammary epithelial cells , Garbe, J.;Wong, M.;Wigington, D.;Yaswen, P.;Stampfer, M.R. , Oncogene / v.18,pp.2169, 1999
  16. Expression of cellular genes in HPV16-immortalized and cigarette smoke condensate-transformed human endovervical cells , Yang, X.;Nakao, Y.;Pater, M.M.;Tang, S.C.;Pater, A. , J. Cell. Biochem. / v.66,pp.309, 1977

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