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논문 상세정보

충치균 (Streptococcus mutans)에 대한 다시마 추출물의 항균활성

Antibacterial Activity of Sea-mustard, Laminaria japonica Extracts on the Cariogenic Bacteria, Streptococcus mutans

초록

우리 나라 연안에서 채취한 해조류 27종의 $80\%$ ethanol 추출물이 Streptococcus mutans KCTC 3300의 증식에 미치는 영향을 검색하고, 다시마의 추출용매별 항균성과, $80\%$ ethanol 추출물을 용매분획하였을 때 획분별 MIC를 측정하였다. S. mutans KCTC 3300에 대한 해조류 추출물의 항균활성은 다시마가 가장 강하였고, 갈파래, 청각, 감태, 곰피 및 미역도 비교적 높은 활성을 나타내었으며 홍조류보다 갈조류와 녹조류에 속하는 종이 대체적으로 강하였다 다시마의 항균활성은 추출용매에 따라 차이가 있었으나 용매별 가용성 획분의 량과 항균성간에는 뚜렷한 관련이 나타나지 않았다. 5. mutans KCTC 3300과 S. sobrinus KCTC 3307에 대한 해조류의 $80\%$ ethanol 추출물의 MIC는 해조류의 종뿐만 아니라 동일한 해조류 추출물의 경우에도 균종에 따라 차이가 있었다. 다시마의 $80\%$ ethanol 추출물을 유기용매를 사용하여 순차 분획하였을 때 항균활성 물질의 대부분은 ether 획 분에 이행하여 이 획분의 MIC는 105$\mu$g/mL이었고, 수용성 획분은 약 5,500$\mu$g/mL의 농도에서도 균의 증식을 저지하지 못하였다.

Abstract

In previous reports the authors have screened the inhibition effects of marine algae extracts on halitosis, and demonstrated that a brown algae, Eisenia bicyclis (' Daehwang') possess not only strong deodorant effect bug also considerable anticariogenic activities. In this study, we screened antibacterial effects of various marine algae, and measured minimum inhibitory concentration (MIC) value of them against mutans streptococci in vitro. Among the 27 species of marine algae, $80\%$ ethanol extract of dried sea-mustard, Laminaria japonica ('Dasima') showed the strongest inhibition activity against Streptococcus mutans KCTC 3300. The extracts of Ulva lactuca ('Galparae'), Codium fragile ('Cheonggak'), Ecklonia cava ('Gamtae'), E. stolonifera ('Gompi') and Undalia Pinnatifida ('Miyeok') showed slightly weaker inhibitory potency than L. japonica. Differences of MIC values in $80\%$ ethanol extract of some species of marine algae were observed depending on test bacterial species, i.e., S. mutans KCTC 3300 or S. sobrinus KCTC 3307. Eighty percent ethanol extract of dried L japonica was fractionated with diethyl ether, chloroform, ethyl acetate, n-buthanol and water successively, The ether-soluble fraction had inhibitory effect on S. mutans KCTC 3300, however the inhibitory effects were not found in the other fractions. The MIC values of $80\%$ ethanol extract and ether fraction were 180 and 105 $\mu$g/mL respectively, while no significant inhibition activity of water-soluble fraction was found even when the fraction was added up to 5,500 $\mu$g/mL.

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이 논문을 인용한 문헌 (11)

  1. Lee, So-Young ; Song, Eu-Jin ; Kim, Koth-Bong-Woo-Ri ; Yoon, So-Young ; Kim, Seo-Jin ; Lee, So-Jeong ; Hong, Yong-Ki ; Lim, Sung-Mee ; Ahn, Dong-Hyun 2009. "Antimicrobial Activity of Ethanol Extract from Sargassum thunbergii" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 38(4): 502~508 
  2. Lee, So-Young ; Song, Eu-Jin ; Kim, Koth-Bong-Woo-Ri ; Yoon, So-Young ; Kim, Seo-Jin ; Lee, So-Jeong ; Hong, Yong-Ki ; Lim, Sung-Mee ; Ahn, Dong-Hyun 2009. "Antimicrobial Activity of Ethanol Extract from Sargassum thunbergii" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 38(4): 502~508 
  3. Kim, Young-Kyoung ; Jeon, Min-Hee ; Park, Yong-Soo ; Hwang, Hyun-Jung ; Lee, Sang-Hyeon ; Kim, Sung-Gu ; Kim, Yuck-Young ; Kim, Mi-Hyang 2010. "The Effect of Ecklonia stolonifera Extracts on Blood Flow and Serum Lipid Level in Ovariectomized Rats" 생명과학회지 = Journal of life science, 20(12): 1851~1858 
  4. Kim, Young-Kyoung ; Kim, Mi-Hyang 2010. "Effect of Ecklonia stolonifera Extracts on Bone Turnover Markers in Ovariectomized Rats" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 39(12): 1769~1775 
  5. Ahn, Seon-Mi ; Hong, Yong-Ki ; Kwon, Gi-Seok ; Sohn, Ho-Yong 2010. "Evaluation of In-vitro Anticoagulation Activity of 35 Different Seaweed Extracts" 생명과학회지 = Journal of life science, 20(11): 1640~1647 
  6. Park, Sook-Jahr ; Park, Chan-Ik ; Kim, Sang-Chan 2010. "Antimicrobial activities of ethanolic extracts of marine resources against Propionibacterium acnes" 大韓本草學會誌 = The Korea journal of herbology, 25(2): 65~70 
  7. 2011. "" Fisheries and aquatic sciences, 14(4): 251~256 
  8. Ahn, Seon-Mi ; Hong, Yong-Ki ; Kwon, Gi-Seok ; Sohn, Ho-Yong 2011. "Evaluation of Antioxidant and Nitrite Scavenging Activity of Seaweed Extracts" 생명과학회지 = Journal of life science, 21(4): 576~583 
  9. Shim, Youn-Soo ; An, So-Youn ; Park, So-Young 2013. "The associations between dietary behavior and subjective measurements of serious dental diseases in nursing home staff" JKSDH : Journal of Korean Society of Dental Hygiene = 한국치위생학회지, 13(3): 377~385 
  10. Oh, Se In ; Sung, Jung Min ; Lee, Kun Jong 2014. "Physicochemical Characteristics and Antioxidative Effects of Barley Soybean Paste (Doenjang) Containing Kelp Extracts" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 43(12): 1843~1851 
  11. Choi, Min ; Yoo, Dong Il ; Shin, Younsook 2014. "Preparation of Lip Balm Utilizing Functionalities of Colorants Extracted from Marine Algae" 韓國染色加工學會誌 = Textile coloration and finishing, 26(2): 124~130 

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