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논문 상세정보


Alpha-viniferin was previously isolated as a cyclooxygenase (COX)-2 inhibitor from Carex humilis (Cyperaceae) and is an oligomeric stilbene compound with benzofuran (BF) moieties in its chemical structure. In the present study, a chemically synthetic BF compound, named as 3,3-dimethyl-2,3,4,6,7,8,9,10,11,12,13,14,15,16,17,18-hexadecahydro-1H-benzo[b] cyclopentadeca[d]furan-1-one, was discovered to inhibit bacterial lipo polysaccharide (LPS)-induced prostaglandin $E_2$ $(PGE_2)$ production in macrophages RAW 264.7. The BF compound exhibited a selectively preferred inhibitory effect on COX-2 activity over COX-1 activity. Furthermore, BF compound inhibited LPS-induced COX-2 expression at transcription level. As a down-regulatory mechanism of COX-2 expression shown by BF compound, suppression of nuclear factor $(NF)-{\kappa}B$ activation has been demonstrated. BF compound inhibited LPS-induced $NF-{\kappa}B$ transcriptional activity and nuclear translocation of $NF-{\kappa}B$ p65, in parallel, but did not affect LPS-induced degradation of inhibitory ${\kappa}B{\alpha}$ protein $(I{\kappa}B{\alpha})$. Taken together, anti-inflammatory effect of BF compound on $PGE_2$ production was ascribed by its down-regulatory action on LPS-induced COX-2 synthesis in addition to inhibitory action on enzyme activity of COX-2.

참고문헌 (18)

  1. Iniguez, M.A., Martinez-Martinez, S., Punzon, C., Redondo, J.M., and Fresno, M., An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes. J. Biol. Chem. 275, 23627-23635 (2000) 
  2. Inoue, H., Nanayama, T., Hara, S., Yokoyama, c., and Tanabe, T., The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells. FEBS Lett. 350, 51-54 (1994) 
  3. Marret, E, Flahault, A., Samama, C.-M., and Bonnet, F., Effects of postoperative, nonsteroidal, anti-inflammatory drugs on bleeding risk after tonsillectomy. Anesthesiology 98, 14971502 (2003) 
  4. Nagano, S., Otsuka, T., Niiro, H., Yamaoka, K, Arinobu, Y., Ogami, E, Akahoshi, M., Inoue, Y., Miyake, K, Nakashima, H., Niho, Y, and Harada, M., Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines. Int. Immunol. 14, 733-740 (2002) 
  5. Rao, A., Luo, C., and Hogan, P.G., Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707-747 (1997) 
  6. Shin, H.-M., Kim, M.-H., Kim, B.H., Jung, S.-H., Kim, Y.S., Park, H.J., Hong, J.T., Min, K.R, and Kim, Y., Inhibitory action of novel aromatic diamine compound on lipopoly saccharide-induced nuclear translocation of NF-KB without affecting IKB degradation. FEBS Lett. 571, 50-54 (2004) 
  7. Simon, L.S., Role and regulation of cyclooxygenase-2 during inflammation. Am. J. Med. 106, S37-42 (1999) 
  8. Yeo, S.J., Yoon, J.G., and Yi, A.K, Myeloid differentiation factor 88-dependent post-transcriptional regulation of cyclo oxygenase-2 expression by CpG DNA: tumor necrosis factoralpha receptor-associated factor 6, a diverging point in the Toll-like receptor 9-signaling. J Biol. Chem. 278, 40590-40600 (2003) 
  9. Moroianu, J., Nuclear import and export pathways. J. Cell. Biochem. 33, 76-83 (1999) 
  10. Needelman, P. and Isakson, P.C., The discovery and function of COX-2. J. Rheumatoz. 24, 6-8 (1997) 
  11. Vane, J.R and Botting, R.M., Overview-mechanisms of actions of anti-inflammatory drugs. In: Vane J, Botting J, Botting R, eds. Improved non-steroidal anti-inflammatory drugs: COX-2 enzyme inhibitors. Boston, Kluwer Academic, 1-127 (1996) 
  12. Moon, K.Y., Hahn, B.S.. Lee, J., and Kim, Y.S., A cell-based assay system for monitoring NF-kappaB activity in human HaCat transfectant cells. Anal. Biochem. 292, 17-21 (2001) 
  13. Chung, E.Y., Kim, B.H., Lee, M.K, Yun, Y.-P., Lee, S.H., Min, K.R, and Kim, Y., Anti-inflammatory effect of the oligomeric stilbene alpha-viniferin and its mode of the action through inhibition of cyclooxygenase-2 and inducible nitric oxide synthase. Planta Med. 69, 710-714 (2003) 
  14. Kolenko, V, Bloom, T., Rayman, P., Bukowski, R, His, E., and Finke, J., Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3. J. ImmunoZ. 163, 590-598 (1999) 
  15. Stamp, L.K, Cleland, L.G., and James, MJ., Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: role of interleukin 17 and tumor necrosis factor-alpha. J.Rheumatol. 31, 1246-1254 (2004) 
  16. Lee, Y.R., Kweon, H.I., Koh, W.S., Min, K.R., Kim, Y., and Lee, S.H., One-pot preparation of pyranoquinolinones by ytterbium(III) trifluoromethanesulfonate-catalyzed reactions : efficient synthesis of flindersine. Synthesis 12, 1851-1855 (2001) 
  17. Lee, S.-H., Shin, N.-H., Kang, S.-H., Park, J.S., Chung, S.R., Min, K.R.., and Kim, Y., Alpha-viniferin: a prostaglandin H2 synthase inhibitor from root of Carex humilis. Planta Med. 64, 204-207 (1998) 
  18. Sadikot, R.T., Christman, J.W., and Blackwell, T.S., Molecular targets for modulating lung inflammation and injury. Curro Drug Targets 5,581-588 (2004). 

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