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Abstract AI-Helper 아이콘AI-Helper

Brazilin shows hypoglycemic effect in diabetic animals through enhancement of glucose metabolisms in insulin responsive tissues. One of the major mechanisms of brazilin to enhance glucose metabolism is stimulation of glucose transport in adipocytes. In this study, the essential molecular moiety of b...

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제안 방법

  • In this study, we examined the production of hydrogen peroxide by brazilin and its role in glucose transport in isolated rat epididymal adipocytes, in order to find the essential moiety of brazilin for the stimulation of glucose transport.

대상 데이터

  • Sprague-Dawley rats were purchased from the Animal Breeding Center of Seoul National University, Korea. The animals were fed with autoclaved rodent laboratory chow and water ad libitum in an air-filtered room.

데이터처리

  • The statistical significance of the differences between groups was analyzed by Student's t. test or ANOVA test (Duncans multiplicity test).
  • The statistical significance of the differences between groups was analyzed by Student's t. test or ANOVA test (Duncans multiplicity test). A level ofP< 0.
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참고문헌 (26)

  1. Bialojan, C. and Takai, A. (1988). Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. Biochem. J. 256, 283-290 

  2. Bracke, M.E., De Pestel, G., Castronovo, V., Vyncke, B., Foidart, J.M., Vakaet, L.C. and Mareel, M.M. (1988). Flavonoids inhibit malignant tumor invasion in vitro. Prog. Clin. BioI. Res. 280, 219-233 

  3. Cohen, P., Alemany, S., Hemmings, B.A., Resink, T.J., Stralfors, P. and Tung, H.Y. (1988). Protein phosphatase-l and protein phosphatase-2A from rabbit skeletal muscle. Methods Enzymol. 159, 390-408 

  4. DeFronzo, R.A., Bonadonna, R.C. and Ferrannini, E. (1992). Pathogenesis of NIDDM. A balanced overview. Diabetes Care. 15,318-368 

  5. DeFronzo, R.A., Gunnarsson, R., Bjorkman, O., Olsson, M. and Wahren, J. (1985). Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J. Clin. Invest. 76, 149-155 

  6. Fidelus, R.K. (1988). The generation of oxygen radicals: a positive signal for lymphocyte activation. Cell. Immunol. 113, 175-182 

  7. Green, A. (1986). The insulin-like effect of sodium vanadate on adipocyte glucose transport is mediated at a post-insulinreceptor level. Biochem. J. 238, 663-669 

  8. Halliwell, B. and Gutteridge, J.M.C. (1988). Free radicals in biology and medicine. Oxford Press., UK 

  9. Hikino, H., Taguchi, T., Fujimura, H. and Hiramatsu, Y. (1977). The validity of oriental medicine. Planta Med. 31, 214-220 

  10. James, D.E. and Piper, R.C. (1994). Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4. J. Cell BioI. 126, 1123-1126, 1994 

  11. Jun, H., Bae, H.Y., Lee, B.R., Koh, K.S., Kim, Y.S., Lee, K.W., Kim, H. and Yoon, J. (1999). Pathogenesis of non-insulindependent (type m diabetes mellitus (NIDDM)-genetic predisposition and metabolic abnormalities. Adv. Drug Deliv. Rev. 35, 157-177 

  12. Khil, L.Y, Han, S.S., Kim, S.G., Chang, T.S., Jeon, S.D., So, D.S. and Moon, C.K. (1999). Effects of brazilin on GLUT4 recruitment in isolated rat epididymal adipocytes. Biochem. Pharmacol. 58, 1705-1712 

  13. Koshio, O., Akanuma, Y. and Kasuga, M. (1988). Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells. Biochem. J. 250, 95-101 

  14. Kruszynska, Y.T. and Olefsky, J.M. (1996). Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J. Investig. Med. 44,413-428 

  15. Mahadev, K., Zilbering, A., Zhu, L. and Goldstein, B.J. (2001). Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J. Biol. Chem. 276, 21938-21942 

  16. Martin, J.P. Jr, Dailey, M. and Sugarman, E. (1987). Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch. Biochem. Biophys. 255, 329-336 

  17. Masaki, H., Atsumi, T. and Sakurai, H. (1995). Detection of hydrogen peroxide and hydroxyl radicals in murine skin fibroblasts under UVB irradiation. Biochem. Biophys. Res. Commun. 206, 474-479 

  18. Moon, C.K., Lee, S.H., Chung, J.H., Won, H.S., Kim, J.Y, Khil, L.Y., et al. (1990). Effects of brazilin on glucose metabolism in isolated soleus muscles from streptozotocin induced diabetic rats. Arch. Pharm. Res. 13, 359-364 

  19. Moon, C.K., Lee, S.H., Lee, M.O. and Kim, S.G. (1993). Effects of Brazilin on glucose oxidation, lipogenesis and therein involved enzymes in adipose tissues from diabetic KK-mice. Life Sci. 53, 1291-1297 

  20. Moon, C.K., Yun, Y.P., Lee, J.H., Wagner, H. and Shin, YS. (1985). Inhibition of lens-aldose reductase activity by brazilin and haematoxylin. Planta Med. 47, 66-67 

  21. Olefsky, J.M. (1975). Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. J. Clin. Invest. 56, 1499-1508 

  22. Sommer, D., Coleman, S., Swanson, S.A. and Stemmer, P.M. (2002). Differential susceptibilities of serine/threonine phosphatases to oxidative and nitrosative stress. Arch. Biochem. Biophys. 404,271-278 

  23. Tanti, J.F., Grillo, S., Gremeaux, T., Coffer, P.J., Van Obberghen, E. and Le Marchand-Brustel, Y. (1997). Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Endocrinology. 138, 2005-2010 

  24. Tonks, N.K., Diltz, CD. and Fischer, E.H. (1988). Characterization of the major protein-tyrosine-phosphatases of human placenta. J. Biol. Chem. 263,6731-6737 

  25. Ugi, S., Imamura, T., Maegawa, H., Egawa, K., Yoshizaki, T., Shi, K., Obata, T., Ebina, Y., Kashiwagi, A. and Olefsky, J.M. (2004). Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-Ll adipocytes. Mol. Cell Biol. 24, 8778-8789 

  26. Yang, K.M., Jeon, S.D., So, D.S. and Moon, C.K. (2000). Brazilin augments cellular immunity in multiple low dose streptozotocin (MLD-STZ) induced type I diabetic mice. Arch. Pharm. Res. 23, 626-632 

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