• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


The Separation of two amino acids, phenylalanine and tryptophan, was carried out using laboratory simulated moving bed (SMB) chromatography. The SMB process consisted of four zones, with each zone having 2 columns. The triangle theory was used to obtain the operating conditions for the SMB. The mass transfer coefficients of the two amino acids were obtained from the best-fit values by comparing simulated and experimental pulse data. The competitive adsorption isotherms of the two amino acids were obtained by single and binary frontal analyses, taking into consideration the competition between the two components. A competitive Langmuir isotherm, obtained from single-component frontal chromatography, was used in the first run, and the isotherm from binary frontal chromatography in the second, with the flow rate of zone 1 modified to improve the purity. Compared to the first and second runs, the competitive Langmuir isotherm from the binary frontal chromatography Showed good agreement with the experimental results. Also, adjusting the flow rate in zone 1 increased the purity of the products. The purities of the phenylalanine in the raffinate and the tryptophan in the extract were 99.84 and $99.99\%$, respectively.

참고문헌 (23)

  1. Broughton, D. B. (1968) Molex case history of a process. Chem. Eng. Prog. 64: 60 
  2. Broughton, D. B., R. W. Neuzil, J. M. Pharis, and C. S. Brearley (1970) The Parex process for recovering paraxylene. Chem. Eng. Prog. 66: 70 
  3. Jupke, A., A. Epping, and H. Schmidt-Traub (2002) Optimal design of batch and simulated moving bed chromatographic separation processes. J. Chrornatogr. A944: 93-117 
  4. Juza, M. (1999) Development of a high-performance liquid chromatographic simulated moving bed separation from an industrial perspective. J. Chrornatogr. A865: 35-49 
  5. Jacobson, J. M. and J. H. Frenz (1990) Determination of competitive adsorption isotherms for modeling large-scale separations in liquid chromatography. J. Chromatogr. 499: 5-19 
  6. Zhu, J., A. M. Katti, and G. Guiochon (1991) Comparison of various isotherm models for predicting competitive adsorption data. J. Chromatogr. A552: 71-89 
  7. Khattabi, S., D. E. Cherrak, J. Fischer, P. Jandera, and G. Guiochon (2000) Study of the adsorption behavior of the enantiomers of 1-phenyl-1-propanol on a cellulose-based chiral stationary phase. J. Chrornatogr. A877: 95-107 
  8. Wu, D.-J., Y. Xie, Z. Ma, and N.-H. L. Wang (1998) Design of simulated moving bed chromatography for amino acid separations. Ind. Eng. Chem. Res. 37: 4023-4035 
  9. Kim, Y. S., C. H. Lee, Y. M. Koo, and P. C. Wankat (2003) Studies on the one-column analogue of a fourzone SMB. Proceedings of the Third Pacific Basin Conference on Adsorption Science and Technology. May 25-29, Kyongju, Korea 
  10. Pynnonen, B. (1998) Simulated moving bed process: Escape from the high-cost box. J. Chrornatogr. A827: 143-160 
  11. Jacobson, J. M., J. H. Frenz, and C. Horvath (1987) Measurement of competitive adsorption isotherms by frontal chromatography. Ind. Eng. Chem. Res. 26: 43-50 
  12. Khattabi, S., D. E. Cherrak, K. Mihlbachler, and G. Guiochon (2000) Enantioseparation of 1-phenyl-1-propanol by simulated moving bed under linear and nonlinear conditions. J. Chrornatogr. A893: 307-319 
  13. Pais, L. S., J. M. Loureiro, and A. E. Rodrigues (2000) Chiral separation by SMB chromatography. Sep. Purif Technol. 20: 67- 77 
  14. Hong, S. P., C. H. Lee, S. K. Kim, H. S. Yun, J. H. Lee, and K. H. Row (2004) Mobile phase compositions for ceramide 3 by normal phase high performance liquid chromatography. Biotechnol. Bioprocess Eng. 9: 47-51 
  15. Heuer, C., E. Kusters, T. Plattner, and A. SeidelMorgenstern' (1998) Designing of the simulated moving bed process based on adsorption isotherm measurements using a perturbation method. J. Chrornatogr. A827: 175-191 
  16. Xie, Y., Y. M. Koo, and N.-H. L. Wang (2001) Preparative chromatographic separation: Simulated moving bed and modified chromatography methods. Biotechnol. Bioprocess Eng. 6: 363-375 
  17. Juza, M., M. Mazzotti, and M. Morbidelli (2000) Simulated moving-bed chromatography and its application to chirotechnology. Trends Biotechnol. 18: 108-118 
  18. Huthmann, E. and M. Juza (2001) Modification of a commercial chiral stationary phase influences on enantiomer separations using simulated moving bed chromatography. J. Chrornatogr. A908: 185-200 
  19. Yang, Y. J., S. H. Hwang, S. M. Lee, Y. J. Kim, and Y. M. Koo (2002) Continuous cultivation of lactobacillus rhamnosus with cell recycling using an acoustic cell settler. Biotechnol. Bioprocess Eng. 7: 357-361 
  20. Ma, Z. and N.-H. L. Wang (1997) Standing wave analysis of SMB chromatography: Linear systems. AIChE J. 43: 2488-2508 
  21. Mazzotti, M., G. Storti, and M. Morbidelli (1997) Optimal operation of simulated moving bed units for nonlinear chromatographic separations. J. Chromatogr. 769: 3-24 
  22. Jacobson, S. C., A. Felinger, and G. Guiochon (1992) Optimizing the sample size and the reduced velocity to achieve maximum production rates of enantiomers. Biotechnol. Prog. 8: 533-539 
  23. Row, K. H., C. H. Lee, and J. H. Kang (2002) Parameter estimation of perillyl alcohol in RP-HPLC by moment analysis. Biotechnol. Bioprocess Eng. 7: 11-16 

이 논문을 인용한 문헌 (3)

  1. 2005. "" Biotechnology and bioprocess engineering, 10(3): 225~229 
  2. 2005. "" Biotechnology and bioprocess engineering, 10(4): 341~345 
  3. 2008. "" Bulletin of the Korean Chemical Society, 29(8): 1549~1553 


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일