• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


When SiHa cells were incubated for varying periods of time with extracts of PFF and PFM, the cytotoxicity of the ethanol extracts of PFF was higher than those of the other extracts. These results indicated that the extracts from fruiting bodies of p. ferulae contain antitumor Substances. When A549, SiHa and HeLa cells were incubated with different concentrations of PFF and PFM extracts, the ethanol extracts of PFF showed strong cytotoxicity against A549 tells at concentrations over $10{\mu}g/mL$ and against SiHa and HeLa cells at concentrations over $40{\mu}g/mL$. However, the differences in the cytotoxic effects of the hot water and ethanol extracts of PFM and the hot water extracts of PFF on all 3 cancer cells were not significant. Also, the PFF ethanol extracts induced synergistic effects on the TRAIL-induced apoptosis in A549 cells, which were strongly resistant to TRAIL. These results indicated that ethanol extracts of PFF were the most prominent antitumor agents toward lung cancer cells (A549).

참고문헌 (21)

  1. Wasser, S. P. and A. L. Weis (1999) Medicinal properties of substances occurring in higher Basidiomycetes mushrooms: Current perspectives. Int. J. Med. Mushrooms 1: 31-62 
  2. Ohno, N., Y. Adachi, I. Suzuki, K. Sato, S. Oikawa, and T. Yadomae (1986) Characterization of the antitumor glucan obtained from liquid cultured Grifola frondosa. Chem. Pharm. Bull. 34: 1709-1715 
  3. Gunde-Cimerman, N. (1999) Medicinal value of the genus Pleurotus (Fr.) P. Karst. Int. J. Med. Mushroom. 1: 69-80 
  4. Paulik, S., S. Svreck, J. Mojzisova, A. Durove, Z. Benishek, and M. Huska (1996) The immunomodulatory effect of the soluble fungal glucan (Pleurotus ostreatus) on delayed hypersensitivity and phagocytic ability of blood leukocytes in mice. Zentrabl Vecterinaermed Reihe B. 43: 129-135 
  5. Guchelaar, H. J., A. Vermes, I. Vermes, and C. Haaden (1997) Apoptosis: Molecular mechanism and implication for cancer chemotherapy. Pharm. World Sci. 19: 119-125 
  6. Ooi, V. E. C. and F. Liu (1999) A review of pharmacological activities of mushroom polysaccharides. Int. J. Med. Mushrooms 1: 195-206 
  7. Yanaki, T., W. Ito, and T. Kojima (1981) Ultrasonic degradation of schizaphyllan, an antitumor polysaccharide produced by Schizophyllum commune FRIES. Carbohydr. Res. 89: 121-135 
  8. Wang, H. and T. B. Ng (2000) Isolation of a novel ubiquitin- like protein from Pleurotus ostreatus mushroom with anti-human immunodeficiency virus, translation-inhibitory and ribonuclease activities. Biochem. Biophys. Res. Commun. 275: 810-816 
  9. Chang, S. T and P. G. Miles (1989) Edible Mushrooms and Their Cultivations. CRC Press Inc., Boca Raton, Florida, USA 
  10. Pitti, R. U., S. A. Marsters, S. Ruppert, C. I. Donahue, A. Moore, and A. Ashkenazi (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokin family. J. BioI. Chem. 271: 1267-1290 
  11. Tzianabos, A. O. (2000) Polysaccharide immunomodulators as therapeutic agents; structural aspects and biological function. Clin. Microbial. Rev. 13: 523-533 
  12. Mizuno, T., P. Yeohlui, T Kinoshita, C. Zhuang, H. Ito, and Y. Mayuzumi (1996) Antitumor activity and chemical modification of polysaccharide from Niohshimeji mush· room, Tricholoma giganteum. Biosci. Biotechnol. Biochem. 60: 30-33 
  13. Noda, S. (1990) A preparation for kidney treatment possessing anti-inflammatory activity, obtained from Basidiomycetes, e.g. Lentinus, Pleurotus, Flammulina, and Tricholoma. Japanese Paten 61,171,428 
  14. Mizuno, T., K. Ohsawa, N. Hagiwara, and R. Kuboyama (1986) Fractionation and characterization of antitumor polysaccharides from maitake Grifola frondosa. Agric. BioI. Chem. 50: 1679-1688 
  15. Borchers, A. T., J. S. Stern, R. M. Hackman, C. L. Keen, and E. M. Gershwin (1999) Mushrooms, Tumors, and Biologically Active Substances. Pergamon Press, New York, USA 
  16. Noda, S. (1998) Antibiotic fungicide extracted from Basidiomycetes culture (e.g. Shitake, Flammulina velutips, Polyporus, Pleurotus, etc.). Japanese Patent 60,190,800 
  17. Breene, W. M (1990) Nutritional and medicinal value of specially mushrooms. J. Food Protection 53: 83 
  18. Czop, J. K. and J. Kay (1991) Isolation and characterization of $\beta$-glucan receptors on human mononuclear phagocytes.J.Exp. Med. 173: 1511-1520 
  19. Suzuki, W. and T. Ikegawa (1998) Anti-cancer substance emitanin. Japanese Patent 53,006,494 
  20. Lorenzen, K. and T. Anke (1998) Basidiomycetes as a source for new bioactive natural products. Curr. Org. Chem. 2: 329-364 
  21. Opletal, L., L. Jahodar, V. Chabot, P. Zdansky, J. Lukes, M. Bratova, D. Solichova, G. Blunden, C. G. Dacke, and A. Patel (1997) Evidence for the anti-hyperlipidaemic activity of the edible fungus Pleurotus ostreatus. Br. Biomed. Sci. 54: 240-243 

이 논문을 인용한 문헌 (5)

  1. 2005. "" Biotechnology and bioprocess engineering, 10(4): 372~377 
  2. 2005. "" Biotechnology and bioprocess engineering, 10(6): 556~563 
  3. 2007. "" Biotechnology and bioprocess engineering, 12(2): 100~105 
  4. 2007. "" Biotechnology and bioprocess engineering, 12(5): 516~524 
  5. 2009. "" Biotechnology and bioprocess engineering, 14(2): 232~237 


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일