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논문 상세정보

초록

한국산 칡 (Pueraria thunbergiana)의 에스트로겐성을 평가하기 위하여 9종의 물질의 함량을 HPLC로 측정하였고, 그들의 에스트로겐성을 in vitro screening test인 estrogen receptor dependent transcriptional expression assay를 이용하여 평가하였다. Phytochemical 함량을 분석한 결과 칡의 대표적 에스트로겐성 물질인 daidzein의 경우, 뿌리>줄기>잎>꽃>종자의 순서로 나타났고, 칡에서 가장 함량이 많은 puerarin의 경우도 뿌리>줄기>일>꽃>종자 순서로 함유되어 있었다. Phytochemical들의 에스트로겐 활성도 측정 결과 효능(potency)은 daidzein>genistein>biochanin A>formononetin>puerarin>genistin >> glycitein = daidzin = glycitin 순이었다. 17$\beta$-estradiol에 대한 1 $\mu$M에서의 상대효율 (relative efficiency)은 genistein>biochanin A>daidzein>genistin>formononetin>puerarin>>glycitein = daidzin = glycitin순이었다. 또한 칡의 부위별, 지역에 따른 칡의 에스트로겐성을 조사하였다. 칡의 부위별 에스트희겐성은 뿌리>줄기>잎>꽃>종자 순으로 나타났다. 또한 지역별로도 칡의 에스트로겐성에서 차이를 보였다: Mokpo>Ulsan> Je-cheon>Pochon>Taebaek>Punggi. 이상의 결과 칡에는 다양한 에스트로겐성 물질이 다량 함유되어 있으며, 뿌리에 가장 많고, 줄기 등 다른 부위에도 함유되어 있음을 알 수 있었다.

Abstract

To assess the estrogenicities of Korean arrowroot (Pueraria thunbergiana) the contents of nine phytochemicals which are known to present were analyzed by HPLC. Also the estrogenecities of these phytochemicals were assayed using estrogen receptor dependent transcriptional expression assay. Daidzein and puerarin are major compounds in arrowroot, which were contained in the order of: root>stem>leaf>flower>seed. Among the assayed phytochemicals daidzein, genistein, biochanin A, formononetin, puerarin and genistin were highly estrogenic. The total estrogenicities in different parts of arrowroot and those by regions in Korea were also assessed. Roots had the highest estrogenic effects. The estrogenicities also were shown in stem and leaf. The differences in the estrogenicities of arrowroots by regions in Korea were shown. These results demonstrated that the estrogenic phytochemicals content was the highest in Korean arrowroot and also present in stem and leaf.

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이 논문을 인용한 문헌 (13)

  1. Park, Chul ; Kim, So-Jung ; Shin, Wan-Chul ; Kim, Hae-Gyoung ; Choe, Suck-Young 2004. "Assessing Heavy Metals for Estrogenicity Using a Combination of In vitro and In vivo Assays" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 33(9): 1486~1491 
  2. Choi, Sun-Young ; Lim, Sun-Hye ; Kim, Ji-Sun ; Ha, Tae-Youl ; Kim, Sung-Ran ; Kang, Kyung-Sun ; Hwang, In-Kyeong 2005. "Evaluation of the Estrogenic and Antioxidant Activity of Some Edible and Medicinal Plants" 한국식품과학회지 = Korean journal of food science and technology, 37(4): 549~556 
  3. Lee, Ji-Hee ; Soung, Yun-Hee ; Lee, Sun-Mee ; Jung, Hee-Sun ; Paik, Jae-Eun ; Joo, Na-Mi 2008. "Optimization of Iced Cookie with Arrowroot Powder Using Response Surface Methology" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 24(1): 76~83 
  4. Hwang, Eun-Hee ; Kim, Kee-Hwan 2008. "A Study on the Quality of Ramyon Made from Korean Wheat and Arrowroot(Pueraria thunbergiana B) Starch" 한국생활과학회지 = Korean journal of human ecology, 17(1): 151~158 
  5. Lee, Myung-Ye ; Chang, Kyung-Ho 2010. "Quality Properties and Isoflavone Contents of Chungkukjang Containing Isoflavone Extracted from Arrowroot (Pueraria lobata Ohwi)" 東아시아食生活學會誌 = Journal of the East Asian Society of Dietary Life, 20(4): 543~550 
  6. Seo, Seung-Min ; Jeong, Yeon-Shin ; Hari, Dhakal Krisna ; Shin, Dong-Hyun ; Lee, In-Jung ; Park, Eun-Sook ; Lee, Jeong-Dong ; Hwang, Young-Hyun 2011. "Variation of Pinitol Content for Domestic Legume Species in Korea" Korean journal of crop science = 韓國作物學會誌, 56(1): 50~56 
  7. 2011. "" Food science and biotechnology, 20(2): 335~341 
  8. 2011. "" Food science and biotechnology, 20(3): 829~833 
  9. Jin, So-Yeon 2011. "Study on Antioxidant Activities of Extracts from Different Parts of Korean and Iranian Pomegranates" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(8): 1063~1072 
  10. Han, Gyusang ; Hwang, Seong-Yun ; Rho, Sujung 2013. "Quality Characteristics of White Bread with Arrowroot Powder" 東아시아食生活學會誌 = Journal of the East Asian Society of Dietary Life, 23(6): 778~788 
  11. Lee, Eunji ; Kwon, Jung Eun ; Kim, Soojung ; Cha, Min-Seok ; Kim, Inhye ; Kang, Se Chan ; Park, Tae-Ho 2013. "Isoflavones and biotransformed dihydrodaidzein production with in vitro cultured callus of Korean wild arrowroot Pueraria lobata" Journal of plant biotechnology = 식물생명공학회지, 40(4): 217~223 
  12. Keum, Joon-Ho ; Seo, Yun-Soo ; Kang, Ok-Hwa ; Choi, Jang-Gi ; Kwon, Dong-Yeul 2013. "Anti-inflammatory effect of Seungmagalgeun-tang extract in human mast cells" 大韓本草學會誌 = The Korea journal of herbology, 28(5): 7~11 
  13. Lee, Jun Young ; Kim, Mi Kyeong ; Ha, Jun Young ; Kim, Yong Gyun ; Hong, Chang Oh ; Kim, So Young ; Kim, Chung-Hwan ; Kim, Keun Ki 2014. "Isolation and Identification of a Photosensitizer from Pueraria thunbergiana Leaves that Induces Apoptosis in SK-HEP-1 Cells" 생명과학회지 = Journal of life science, 24(3): 242~251 

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