$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Synthesis and Study of Antibacterial and Antifungal Activities of Novel 2-[[(Benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.27 no.11, 2004년, pp.1081 - 1085  

Kaplancikli, Zafer-Asim (Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry) ,  Gulhan, Turan-Zitouni (Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry) ,  Revial, Gilbert (Laboiratoire de Chimie Organique, CNRS (ESA 7084) ESPCI) ,  Guven, Kiymet (Anadolu University, Faculty of Science, Department of Biology)

Abstract AI-Helper 아이콘AI-Helper

Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of $K_2CO_3$. The chemical structures of the compounds w...

주제어

AI 본문요약
AI-Helper 아이콘 AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

대상 데이터

  • In this study, 12 new compounds were synthesized. The structures of the obtained compounds were elucidated by spectral data.

이론/모형

  • Antimicrobial activities of compounds were tested using the microbroth dilution method (Koneman et al., 1997). Tested microorganism strains were Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans and Candida globrata (isolates obtained from Osmangazi llni.
본문요약 정보가 도움이 되었나요?

참고문헌 (30)

  1. Alexander, B. D. and Perfect, J. R., Antifungal resistance trends towards the year 2000 Implications for therapy and new approaches. Drugs, 54, 657-678 (1997) 

  2. Amyes, S. G. B. and Gemmell, C. G., Antibiotic resistance Proceedings of a symposium held on 12 July 1996 at the University of Southampton. J. Med. Microbiol., 46, 436-470(1997) 

  3. Ates, O., Altintas, H. and Otuk, G., Synthesis and antimicrobial activity of 4-carbethoxymethyl-2-[(alpha-haloacyl)amino]thiazoles and 5-nonsubstituted/stituted 2-[(4-carbethoxy-methylthiazol-2-yl)imino]-4-thiazolidinones. Arzneim. Forsch., 50, 569-575 (2000). 

  4. Cassell, G. H. and Mekalanos, J., Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance. J. Am. Med. Assoc., 285, 601-605 (2001) 

  5. Cetinkaya, Y., Falk, P., and Mayhall, C.G., Vancomycin-resistant enterococci. Clin. Microbiol. Rev., 13, 686-707 (2000) 

  6. Chu, D. T. W., Plattner, J. J., and Katz, L., New directions in antibacterial research. J. Med. Chem., 39, 3853-3874 (1996) 

  7. Cunha, B. A., Antibiotic resistance. Drugs Today, 34, 691-698 (1998) 

  8. Doern, G. V., Antimicrobial use and the emergence of antimicrobial resistance with Streptococcus pneumoniae in the United States. Clin. lnfect. Dis., 33,187-192 (2001) 

  9. Goodman-Gilman, A., The pharmacological basis of therapeutics. McGraw-Hill company, USA, (2001) 

  10. Gringauz, A., Introduction to Medicinal Chemistry, How Drug Act and Why., Wiley-VCH Inc., USA (1997) 

  11. Healy, V. L., Lessard, I. A. D., Roper, D. I., Knox, J. R. and Walsh, C. T., Vancomycin resistance in enterococci: reprogramming of the D-Ala-D-Ala ligases in bacterial peptidoglycan biosynthesis. Chem. Biol., 7, 109-119 (2000) 

  12. Hood, S. and Denning, D. W., Treatment of fungal infection in AIDS, J. Antimicrob. Chemoth., 37, 71-85 (1996) 

  13. Hubschwerlen, C., Pflieger, P., Specklin, J. L., Gubernator, K., Gmunder, H., Angehrn, P., and Kompis, I., Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors. J. Med. Chem., 35, 1385-1392 (1992) 

  14. Joule, J. A. and Mills, K., Heterocyclic Chemistry, Blackwell Science Ltd., Oxford, (2000) 

  15. Kim J. S., Sun, Q., Gatto, B., Yu, C., Liu, A., Liu, L. F., and LaVoie, E. J., Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons. Bioorg. Med. Chem., 4, 621-630 (1996) 

  16. Koneman, E. W., Allen, S. D., and Winn, W. C., Colour Atlas and Textbook of Diagnostic Microbiology, Lippincott Raven Pub., Philadelphia, (1997) 

  17. Lakhan, R., Sharma, B. P., and Shukla, B. N., Synthesis and antimicrobial activity of 1-aryl-2-amino-3-(4-arylthiazol-2-yl)/(benzothiazol-2-yl)guanidines. Farmaco, 55, 331-337 (2000) 

  18. Levy, S. B., The challenge of antibiotic resistance. Sci. Am., 278, 46-53 (1998) 

  19. Lipsitch, M., The rise and fall of antimicrobial resistance. Trends Microbiol., 9, 438-444 (2001) 

  20. Lopez-Garcia, B., Veyrat, A., Perez-Paya, E., Gonzalez-Candelas, L., and Marcos, J. F., Comparison of the activity of antifungal hexapeptides and the fungicides thiabendazole and imazalil against postharvest fungal pathogens. Int. J. Food Microbiol., 89, 163-170, (2003) 

  21. Marchese, A., Schito, G. C., and Debbia, E. A, Evolution of antibiotic resistance in gram-positive pathogens. J. Chemotherapy, 12, 459-462 (2000) 

  22. Onoe, H. and Takahashi, H., Jpn. Kokai. Tokkyo Koho JP 03 87,841 (1994). Chem. Abstr., 121,205336 (1994) 

  23. Pandeya, S. N., Sriram, D., and Nath, G., Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4'-chlorophenyl)thiazol-2-yl] thiosemicarbazide. Eur. J. Pharm. Sci., 9, 25-31 (1999) 

  24. Perrin, L., Rakik, A., Yerly, S., Baumberger, C., Kinlochde-Loes, S., Pechere, M., and Hirschel, B., Combined therapy with zidovudine and L-697,661 in primary HIV infection. AIDS, 10, 1233-1237 (1996) 

  25. Rapp, R. P., Antimicrobial resistance in gram-positive bacteria: The myth of the MIC. Pharmacotherapy, 19, 112-119 (1999) 

  26. Rybak, M. J. and Akins, R. L., Emergence of methicillin-resistant Staphylococcus aureus with intermediate glycopeptide resistance-Clinical significance and treatment options. Drugs, 6,1-7 (2001) 

  27. Silverman, R. B., Organic chemistry of Drug Desing and Drug Action, Academic press, San Diego, (1992) 

  28. Thompson, L. A. and Ellman, J. A., Synthesis and applications of small molecule libraries. Chem. Rev., 96, 555-600 (1996) 

  29. Turan-Zitouni, G. and Kaplancikli, Z. A., Some new 2,3-dihydro-3-benzofuranamine derivatives. Boll. Chim. Farmaceutico, 137, 367-371 (1998) 

  30. Turan-Zitouni, G., Demirayak, S., Ozdemir, A., Kaplancikli, Z. A., and Yildiz, M. T., Synthesis of some 2-[(benzazole-2yl)thioacetylamino]thiazole derivatives and their antimicrobial activity and toxicity. Eur. J. Med. Chem., 39, 267-272 (2004) 

저자의 다른 논문 :

관련 콘텐츠

오픈액세스(OA) 유형

FREE

Free Access. 출판사/학술단체 등이 허락한 무료 공개 사이트를 통해 자유로운 이용이 가능한 논문

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트