Onkol, Tijen
(Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University)
,
Sahin, M.Fethi
(Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University)
,
Yidirim, Engin
(Department of Pharmacology, Faculty of Medicine, Osmangazi University)
,
Erol, Kevser
(Department of Pharmacology, Faculty of Medicine, Osmangazi University)
,
Ito, Shigero
(Institute for Medicinal and Dental Engineering, Tokyo Medicinal and Dental University)
In this study, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and $^1H-NMR$ spectral data and microanalysis. The compounds were tested for anti nociceptive activity by using the tail clip, ta...
In this study, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and $^1H-NMR$ spectral data and microanalysis. The compounds were tested for anti nociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods. The varying levels of anti nociceptive activity of the compounds were compared with those of dipyrone and aspirin. Among these compounds, compound 5e, 5g, and 5h have been found to be significantly more active than the others and the standards in all the tests.
In this study, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and $^1H-NMR$ spectral data and microanalysis. The compounds were tested for anti nociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods. The varying levels of anti nociceptive activity of the compounds were compared with those of dipyrone and aspirin. Among these compounds, compound 5e, 5g, and 5h have been found to be significantly more active than the others and the standards in all the tests.
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대상 데이터
Chemicals and all the solvents used in this study were locally purchased from Merck A. G. and Aldrich Chemical. Melting points were determined on Electrothermal-9300 Digit기 Melting Point Apparatus.
데이터처리
All tests were conducted between 9 and 12 a.m., and all results were expressed as the mean±S.D. Statistical comparisons were performed by using the St니dent's & test.
이론/모형
,2000), also show a central analgesic effect, the tail clip test to pressure, tail flick to radiant heat, and hot plate test were 니sed to test for central antinociceptive activity. Peripheral activity was evaluated using the acetic acid- ind니ced stretching test (Koster et al., 1959). All compounds had both the central and peripheral antinociceptive activities, and their activities were greater than that of dipyrone which was administered at the same dose.
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