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논문 상세정보

Abstract

The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.

참고문헌 (19)

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이 논문을 인용한 문헌 (4)

  1. Choi, Moo-Young ; Park, Hee-Juhn 2005. "In vitro Atiinflmmatory Activity of Paeonol from the Essential Oil and Its Derivative Methylpaeonol" 생약학회지, 36(2): 116~120 
  2. 2008. "" Natural product sciences, 14(3): 202~205 
  3. Lee, Jae-Woong ; Kim, Young-Hwa ; Ko, Byoung-Seob ; Ryuk, Jin-Ah ; Oh, Seung-Eun ; Park, Sang-Un ; Lee, Mi-Young 2010. "ITS-PCR Analysis for the Discrimination of Moutan Cortex" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 18(1): 40~45 
  4. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1443~1450 

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