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논문 상세정보

Abstract

Lonicera japonica Thunb.(Caprifoliaceae) has long been known as an anti-inflammatory. In the present study, the effect of water fraction of Lonicera japonica (LJ) on trypsin-induced mast cell activation was examined. HMC-1 cells were stimulated with trypsin (100 nM) in the presence or absence of LJ (10, 100, and 1000 $\mu$ g/mL). TNF-$\alpha$ and tryptase production were measured by enzyme-linked immunosorbent assay (ELISA) and reverse transcription-PCR. Extracellular signal-regulated kinase (ERK) phosphorylation was assessed by Western blot. Trypsin activity was measured by using Bz-DL-Arg-p-nitroanilide (BAPNA) as substrate. LJ (10, 100, and 1000 $\mu$g/mL) inhibited TNF-$\alpha$ secretion in a dose-dependent manner. LJ (10, 100, and 1000 $\mu$g/mL) also inhibited TNF-$\alpha$ and tryptase mRNA expression in trypsin-stimulated HMC-1. Furthermore, LJ inhibited trypsin-induced ERK phosphorylation. However, LJ did not affect the trypsin activity even 1000 $\mu$g/mL. These results indicate that LJ may inhibit trypsin-induced mast cell activation through the inhibition of ERK phosphorylation than the inhibition of trypsin activity.

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이 논문을 인용한 문헌 (3)

  1. 2007. "" Journal of plant biology = 식물학회지, 50(3): 315~320 
  2. Kim, Yong ; Yang, Su-Young ; Oh, Young-Seon ; Lee, Jin-Woo ; Lee, Yong-Koo ; Park, Yang-Chun 2010. "Research trends of Lonicera japonica over the last 10 years" 論文集 : 大田大學校 韓醫學硏究所. 韓醫學編, 19(1): 17~23 
  3. 2011. "" Oriental pharmacy and experimental medicine, 11(4): 287~292 

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