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제안 방법
- Here in this study, we examined changes of the rats response to thermal and mechanical stimulus after a high dose injection of CAP in the presence or absence of the induction of inflammation by CAR. We then tested the response of the rats to various stim니li like heat, mechanical, and chemical pain-producing stimuli, and we examined the expression level of VR1.
- In order to examine whether the CAP-treated rats had different pain recognition compared to the control group, we performed the pain behavioral test, We first performed the thermal pain test. We measured the paw withdrawal latency time (PWL) and tail flick latency time (TFL).
- In order to examine whether the CAP-treated rats show different sensitivity to CAP compared to the control group rats, we performed the CAP sensitivity test (Fig. 5). When we applied CAP to the eye of the rats, the CAP-treated rats show a significant decrease in the number of wipes and winks compared to the control group, s니ggesting that the CAP-treated rats showed a m녀아! decreased CAP sensitivity compared to the control group.
- In order to examine whether the different sensitivity of the CAP-treated rats to the pain resulted from changes in the VR1 expression, we examined the VR1 protein level in the DRG of both g「(기jps of rats by western blotting. The decrease in VR1 was a common phenomenon in both groups as time went by.
- In this study, we investigated the effect of a high-dose application of capsaicin on pain sensitivity, and we examined the VR1 expression level. We found that the CAP treatment of neonatal rats reduced their pain sensitivity to mechanical and chemical stimuli and this seems to res니It from the decreased expression of VR1 protein in the DRG.
- We then examined their appearance and performed the behavioral tests inchjding application of thermal and mechanical pain-evoking stimuli at 10 days and at two, three, fo니r, five and six weeks after the CAP treatment.
- of inflammation by CAR. We then tested the response of the rats to various stim니li like heat, mechanical, and chemical pain-producing stimuli, and we examined the expression level of VR1.
데이터처리
- The paired Students t test was used for comparing two means, lb compare multiple means, two-way ANOVA testing was used followed by a Tukeys post hoc test. The results were considered as significant when the P values < 0.
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