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초록

돼지 말초혈액 탐식세포(PMN 및 monocyte)의 탐식성에 있어서 CLA 이성체의 탐식증강 효과를 검토하였다. 탐식세포의 탐식석은 fowl cytomery로 분석하였으며 결과는 다음과 같다. 1. CLA 이성체(CLA mixture, 10t-12c CLA, 9c-11t CLA, 9c-11c CLA, 9t-11t CLA)를 직접 첨가하여 배양한 PMN과 PBMC 및 fowl cytometry cytograpy에서 세포크기에 의해 분획한 monocyte-rich fractiondpsms 탐식증강 효과가 없었다. 2. 각각의 CLA 이성체로 배양한 PBMN 배양상층액으로 PBMC의 탐식활성을 측정한 결과 증강효과는 관찰되지 않았다. 3. CLA 이성체로 배양한 PBMC 배양상층액 중 CLA mixture, 10t-12c CLA, 9c-11c CLA 처리군에서는 PMN과 monocyte-rich fraction의 탐식활성에 있어서 현저한 증강효과가 관찰되었다. 그러나, 말초혈액 탐식세포들은 9c-11c CLA와 9t-11t CLA로 배양한 PBMC 배양상층액에 의해서는 증강효과가 나타나지 않았다. 4. CLA 이성체로 배양한 PMN 배양상층액에 있어서는 PMN과 monocyte-rich fraction의 탐식성을 측정한 결과, 어느 경우에도 증강효과는 나타나지 않았다. 이상의 결과로부터 CLA 중 CLA mixture, 10t-12c CLA. 9c-11t CLA가 돼지 말초혈액 탐식세포에 대하여 탐식증강효과를 가지고 있으며 이러한 증강효과는 직접적이라기보다는 CLA에 의해 활성화된 단핵구세포에서 분비되는 탐식촉진인자를 함유한 가용성 물질에 의해 autocrine 또는 paracrine 양상으로 탐식세포에 작용하는 것으로 생각되었다.

Abstract

The immunoenhancing effect of CLA isomers (CLA mixture, 10t-12c CLA, 9c-11c CLA, 9c-11c CLA, and 9t-11t CLA) on phagocytic activity of porcine peripheral blood leukocytes was examined. The phagocytic activities of peripheral blood mononuclear cells (PBMC) and polymorphonuclear cells (PMN) were analyzed by a flow cytometry system. The direct treatments of CLA isomers have no effect on phagocytosis of PMN as well as PBMC composed of approximately 10% monocytes and 90% lymphocytes. However, the phagocytic activities of PMN and monocyterich fraction from PBMC were remarkably enhanced by culture supernatant from PBMC treated with CLA mixture, 10t-12c CLA and 9c-11t CLA but not 9c-11c CLA and 9t-11t CLA. The phagocytic activity of PBMC was not enhanced by culture supernatant from PBMC treated with all CLA isomers. These results indicated that CLA isomers such as CLA mixture, l0t -12c CLA and 9c-11t CLA have an enhancing effect on phagocytosis of PMN and monocytes, which may be mediated through active humoral substances produced by CLA-stimulated PBMC. This study suggested that CLA stimulates PBMC to elaborate soluble factor(s), which may be an important mechanism for the enhancement of phagocytosis in non-specific immunity.

참고문헌 (40)

  1. Beutler B, Cerami A. Cachectin: more than a tumor necrosis factor. N Engl J Med 1987; 316: 379-385 
  2. Boyaka PN, McGhee JR. Cytokines as adjuvants for the induction of mucosal immunity. Adv Drug Deliv Rev 2001; 51: 71-79 
  3. Hirota Y, Yang MP, Araki S, Yoshihara K, Furusawa S, Yasuda M, Mohamed A, Matsumoto Y, Onodera T. Enhancing effects of chicken egg white derivatives on the phagocytic response in the dog. J Vet Med Sci 1995; 57:825-829 
  4. Ip C, Chin SF, Scimeca JA, Pariza MW. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res 1991; 51: 6118-6124 
  5. Ip C, Singh M, Thompson HJ, Scimeca JA. Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res 1994; 54: 1212-1215 
  6. Kim JH, Chung CS, Lee CY, Yang MP. Immunoenhancing effects of conjugated linoleic acid on chemotactic activity of porcine peripheral blood polymorphonuclear cells. J Vet Clin 2003, 20: 1-6 
  7. Ko IK, Kim JH, Lee GS, Jeung EB, Yang MP. Phagocytosis promotingactivity in culture supernatant from porcine peripheral blood mononuclear cells (MNC) cultured with egg white derivatives (EWD) by tumor necrosis factor (TNF)-$\alpha. Korean J Vet Res 2001: 41 (suppl.): P49 
  8. Park SH, Yun YW, Yang MP. Effect of ginseng saponins on phasocytosis of feline peripheral blood phagocytes. Korean J Vet Clin Med 1998; 15: 116-123 
  9. Shalaby MR, Aggarwal BB, Rinderknecht E, Svedersky LP, Finkle BS, Palladino MA Jr. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factor. J Immunol 1985; 135: 2069-2073 
  10. Trinchieri G. A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigenspecific adaptive immunity. Annu Rev Immunol 1995; 13: 251-276 
  11. Underhill DM, Ozinsky A. Phagocytosis of microbes: Complexity in action. Annu Rev Immunol 2002; 20: 825-852 
  12. Thornton AJ, Strieter RM, Lindley I, Baggiolini M, Kunkel SL. Cytokine-induced gene expression of a neutrophil chemotactic factor/IL-8 in human hepatocytes. J Immunol 1990: 144: 2609-2613 
  13. Aloisi F, Care A, Borsellino G, Gallo P, Rosa S, Bassani A, Cabibbo A, Testa U, Levi G, Peschle C. Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1$\^a$ and tumor necrosis factor-$\alpha. J Immunol 1992; 149: 2358-2366 
  14. van der Pouw Kraan TC, Boeije LC, Smeenk RJ, Wijdenes J, Aarden LA. Prostaglandin-$E_2 is a potent inhibitor of human interleukin 12 production. J Exp Med 1995; 181: 775-779 
  15. Wong MW, Chew BP, Wong TS, Hosick HL, Boylston TD, Shultz TD. Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. Anticancer Res 1997; 17: 987-993 
  16. Ha YL, Storkson J, Pariza MW. Inhibition of benzo(a) pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res 1990; 50:1097-1101 
  17. DeVoney D, Pariza MW, Cook ME. Trans-lO, cis-l2 octa decadienoic acid increases lymphocyte proliferation. FASEBJ 1999; 13:456-461 
  18. Shultz TD, Chew BP, Seaman WR. Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. Anticancer Res 1992; 12: 2143-2145 
  19. Pariza MW, Park Y, Cook ME. Mechanisms of action of conjugated linoleic acid: evidence and speculation. Proc Soc Exp Biol Med 2000; 223: 8-13 
  20. Schonberg S, Krokan HE. The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation. Anticancer Res 1995; 15: 1241-1246 
  21. Sugano M, Tsujita A, Yamasaki M, Noguchi M, YamadaK. Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids 1998; 33: 521-527 
  22. Zhao B, Collins MT, Czuprynski CJ. Effects of gamma interferon and nitric oxide on the interaction of Mycobacterium avium subsp. paratuberculosis with bovine monocytes. Infect Immun 1997; 65: 1761-1766 
  23. Ha YL, Grimm NK, Pariza MW. Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J Agric Food Chem 1989; 37: 75-81 
  24. Pariza MW, Park Y, Cook ME. The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 2001; 40: 283-298 
  25. Ha YL, Grimm NK, Pariza MW. Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcionogenesis 1987; 8: 1881-1887 
  26. Li Y, Watkins BA. Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids 1998; 33: 417-425 
  27. Pece S, Giuliani G, Fumarola D, Mastroianni CM, Lichtner M, Vullo V, Antonaci S, Jirillo E. In vitro production of tumor necrosis factor-$\alpha, interleukin-6 and interleukin-8 from normal human peripheral blood mononuclear cells stimulated by Rhodococcus equi. Vet Microbio 1997; 56: 277-285 
  28. Yang MP, Kim KH. Effect of egg white derivatives on phagocytic response of feline peripheral blood phagocytes. Korean J Vet Clin Med 1999; 16: 37-41 
  29. Yang MP, Kim KH. Detection of phagocytosis-promoting factor of culture supernatant from feline peripheral blood mononuclear cells cultured with egg white derivates. Korean J Vet Clin Med 1999; 16: 31-36 
  30. Le J, Vilcek J. Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab Invest 1987; 56: 234-248 
  31. Sugano M, Tsujita A, Yamasaki M, Yamada K, Ikeda I, Kritchevsky D. Lymphatic recovery, tissue distribution, and metabolic effects of conjugated linoleic acid in rats. J Nutr Biochem 1997; 8: 38-43 
  32. Young MR, Wheeler E, Newby M. Macrophage mediated suppression of natural killer cell activity in mice bearing Lewis lung carcinoma. J Natl Cancer Inst 1986; 76: 745-750 
  33. Cook ME, Miller CC, Park Y, Pariza MW. Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression. Poult Sci 1993; 72: 1301-1305 
  34. Scales WE, Chensue SW, Ottemess I, Kunkel SL. Regulation of monokine gene expression: prostaglandin $E_2 suppresses tumor necrosis factor but not interleukin-l alpha or betamRNA and cell-associated bioactivity. J Leukoc Biol 1989;45: 416-42 
  35. Imir T, Sibbitt W, Bankhurst A. The relative resistance of lymphokine activated killer cells to suppression by prostaglandins and glucocorticoids. Prostaglandins Leukot Med 1987; 28: 111-118 
  36. Michal JJ, Chew BP, Schultz TD, Wong TS. Interaction of conjugated dienoic derivatives of linoleic acid with $\alpha carotene on cellular host defense. FASEB J 1992; 6: 1102-1108 
  37. Christie WW, Dobson G, Gunstone FD. Isomers in commercial samples of conjugated linoleic acid. Lipids 1997; 32: A1231 
  38. Shultz TD, Chew BP, Seaman WR, Luedecke LO. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells. Cancer Lett 1992; 63: 125-133 
  39. Liu KL, Belury MA. Conjugated linoleic acid modulation of phorbol ester-induced events in murine keratinocytes. Lipids 1997; 32: 725-730 
  40. Nugteren DH. Inhibition of prostaglandin biosynthesis by 8cis, 12trans, 14cis-eicosatrienoic acid and 5cis, 8cis, 12trans, 14cis-eicosatetraenoic acid. Biochim Biophys Acta 1970;210: 171-176 

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