• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보


Michael addition of certain nucleophiles on ${\alpha}$ , ${\beta}$-unsaturated ketones 1 led to the formation of adducts 2-7 as well as the reaction of arylidene derivatives with secondary amines afforded the amino compounds 9 and 11. Also, dialkylmalonates were treated with ${\alpha}$-cyano cinnamide to afford 13. On the other hand, double Michael cycloaddition of ethylcyanoacetate or tetrachlorophthalic anhydride to the suitable divinylketone were synthesized to produce 15-17. Selected compounds (13 and 6) were screened for muscle relaxant, anticonvulsant, and sedative activities using established pharmacological models. Their activities were compared with that of phenobarbital sodium taken as standard. Compound 6 was the most potent muscle relaxant while compounds 13a and 13c offered the highest anticonvulsant activity. Meanwhile compound 13c showed the highest potentiation of phenobarbital induced sleep in mice.

참고문헌 (20)

  1. Allen, L. E., Ferguson. H. C., and Kissel, J. W., Psychosedative Agents2,8-(4-substituted-1-piperazinylalkyl)-8-azaspiro-[4.5]decane- 7,9-diones. J. Med. Chem., 15, 477 (1972) 
  2. Braulio, I, Alfredo, P., John, V., and Jairo, Q., Synthesis of 2,3dihydropyrido and 2,3-dihydropyrimido[1,4] diazepines from triamino pyridine and triamino pyrimidine. J. Heterocyclic Chem., 34, 1555 (1997) 
  3. Reddy, D. B., Padmavathi, V., and Reddy, P. V. R., Cyclokexanone dicarboxylates as precursors for the synthesis of some spiropyrimidinetetrones and spiropyrazolidinetriones. Indian J. Chem., 31 B, 774 (1992) 
  4. Vollhardt, K. P. C., Organic Chemistry., W .H. Freeman and Company New York 3rd Edition, 1048 (1999) 
  5. Reddy, T. I. and Varma, R. S., Rare-earth (RE) exchanged nay zeolite promoted Knoevenagel condensation. Tetrahedron Lett., 38, 1721 (1997) 
  6. Sykes, P., A quidebook to Mechanism in Organic Chemistry Long mon London and New York, New York, 5th Edition, 198 (1985) 
  7. Carrol, F. A., Prespectives on structure and Mechanism. In Organic Chernistry. Brooks/Cole Publishing Company 3rd Edition 645 (1988) 
  8. Goehring, R. R, Greenwood, T. D., Nwokogus, G. C., Pisipati, J. S., Rogers, T. G., Wolfe, J. F. (Harvey W. Peters Res Cent. Study Parkinsons Dis. Disord. Cent. Nerv. Syst. Virginia Polytechnic Inst. And state Univ. Blacksburg. VA 24061 USA), Synthesis and anticonvulsant activity of 2-benzylglutarimides. J. Med. Chem., 33 (3), 926 (Eng) (1990). T.C.A 112, 118615p (1990) 
  9. Sergio, M., Tiziane, B., Enzo, B., Metlide, B. (Farmitalia Carlo Erba S.R.I.) Eur. Pat. Appl. Ep 449, 346 (CI C07D 457/02), 02 Oct 1991. GB Appl. 9016, 722, 27 Mar 1990; 9 pp.; preparation of [(4.piperidinyl)akyl] ergolines as antiparkinson agents; T.C.A. 116, 21303e (1992) 
  10. Osman, A. N., Kandeel, M. M., Said, M. M., and Ahmed, E. M., Synthesis and anticonvulsant activity of some spiro compound derived from barbituric and thiobarbituric acids. Indian J. Chem., 35 B, 1073 (1996) 
  11. James, A. R., Gordon, D. J., Witold, F. K., Teanby, H. S., and John, W. P. (wellcome Foundation Ltd.), PCT Int. Appl. WO 9501326 (CI. Co7 C233/25), 12 Jan 1995, GB Appl. 93/13, 459, 30 Jun 1993; 60pp., Preparation of antiatheroscierotic diaryl compounds; T.C.A. 123, 143447V. (1995) 
  12. Aboal-Enein, M. N. and El-Azzouny, A. A., A Facile Synthesis of 2',3',7',8'-Tetrahydro-7'-Aryl and Aralkylspiro[cycloalkyl 1,6'(5'H)-imidazo[1,2-a] pyrazin]-5'-ones. A Heterocycle of Potential Analgesic Profile. Egypt. J. Chem., 31, 141 (1988). 
  13. Bose, M., Dutta, D., Pathak, B., and Patra, B., Synthesis of some spiro[5.5] undecanes as possible Analgesic agents. J. Indian Chem. Soc., 62, 69 (1985) 
  14. Meyers, F. H. Jawetz, E., and GoldFien, A., Review of Medicinal Pharmaacology., Lange Medical Publications, Los Atlos, California; 5th Edition, 222 (1976) 
  15. Vogel, A. G. and Vogel, W. H., Drug Discovery and Evaluation, Pharmacological Assay, Spring, Berlin 260 (1997) 
  16. Villar, R., Laguna, M. R., Calleja, J. M., and Cadavid, I., Effect of Kseletonema statum extracts on the central nervous system. Planta Med., 38, 398 (1992) 
  17. Bloom, F., Neurotransmission and the Centralnervoussystem. In the Pharmacological basis of therapeutics. Hardman J, Limbird L, Goodman A (eds). 10th Edition McGraw Hill Companies Jne. New York, USA(2001). 
  18. Collins, I., Moyes, C., Davey, W., Rowley, M., Bromidge, F., Quirk, K., Atack, J., McKernan, R., Thompson, S. A., Wafford, K., Dawson, G., Pike, A., Sohal, B., Tsou, N., Bull, R., and Castro, J., 3-Heteroaryl-2-pyridones: Benzodiazepine site ligands with functional selectivity for $\alpha$2/$\alpha$3-subtypes of human GABAA receptor-ion channels. J. Med. Chem., 45, 1887-1900 (2002) 
  19. March, J., Advanced Organic Chemistry. John Willey and Sons, 4th Edition,741 (2000) 
  20. De, A. U. and Pal, D., Possible Antineoplastic Agents 11., J. Pharm. Sci., 66, 232 (1977) 

이 논문을 인용한 문헌 (1)

  1. 2013. "" Fisheries and aquatic sciences, 16(1): 1~5 


원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일