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논문 상세정보


Phosphodiesterase (PDE) 4 is an enzyme that degrades intracellular cAMP. In the present study, the effect of rolipram, a specific phosphodiesterase (PDE) 4 inhibitor, on osteoclast formation was investigated. Rolipram induced osteoclast formation in cocultures of mouse bone marrow cells and calvarial osteoblasts. This activity was not observed in the absence of calvarial osteoblasts, suggesting that calvarial osteoblasts are likely target cells of rolipram. Osteoclast formation by rolipram was completely blocked by the addition of osteoprotegerin (OPG), a soluble decoy receptor for the osteoclast differentiation factor, TNF-related activation-induced cytokine (TRANCE, identical to RANKL, ODF, and OPGL). Northern blot analysis revealed the effect of rolipram to be associated with the increased expression of TRANCE mRNA in mouse calvarial osteoblasts. Collectively, these data indicate that PDE4 inhibitor up-regulates the TRANCE mRNA expression in osteoblasts, which in turn controls osteoclast formation.

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참고문헌 (18)

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이 논문을 인용한 문헌 (3)

  1. Lee, Hyo-Keun ; Hwang, Gwi-Seo 2010. "Effects of Securinega suffructicosa(SS) Extract on Osteoclastogenesis and Gene Expression in RANKL-induced RAW Cell" 대한예방한의학회지 = Journal of Society of Preventive Korean Medicine, 14(3): 13~26 
  2. Song, Young-Hun ; Yoo, Jeong-Eun ; Lim, Hyun-Jung ; Yoo, Dong-Youl 2010. "Effects of Clematidis Radix Extract on Osteoclastogenesis and Gene Expression in RANKL-induced RAW 264.7 Cell" 大韓韓方婦人科學會誌 = The Journal of Korean obstetrics & gynecology, 23(3): 78~90 
  3. Kim, Joon-Yeon ; Hwang, Gwi-Seo 2010. "The Effects of Cuscuta japonica Chois on Gene Expression in RANKL-induced RAW 264.7 Cell" 대한예방한의학회지 = Journal of Society of Preventive Korean Medicine, 14(2): 77~89 


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