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Enantioseparation of Flurbiprofen and Ketoprofen in Patches and in Urine Excretions by Achiral Gas Chromatography 원문보기

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.27 no.12, 2004년, pp.1295 - 1301  

Paik, Man-Jeong (College of Pharmacy, Sungkyunkwan University) ,  Nguyen, Duc-Toan (College of Pharmacy, Sungkyunkwan University) ,  Kim , Kyoung-Rae (College of Pharmacy, Sungkyunkwan University)

Abstract AI-Helper 아이콘AI-Helper

The enantiomeric composition tests on flurbiprofen and ketoprofen present in patch products and in urine excretions following patch applications were performed as diastereomeric (R)-(+)- 1-phenylethylamides by achiral gas chromatography and by gas chromatography-mass spectrometry in selected ion mon...

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참고문헌 (24)

  1. Abushoffa, A. M., Fillet, M., Hubert, P., and Crommen, J.,Prediction of selectivity for enantiomeric separations of uncharged compoundsby capillary electrophoresis involving dual-cyclodextrin systems. J. Chromatogr. A, 948, 321-329 (2002) 

  2. Ameyibor, E. and Stewart, J. T., HPLC determination of ketoprofen enantiomers in human serum using a nonporous octadecylsilane 1.5 mm column with hydroxypropyl $\beta$ -cyclodextrin as mobile phase additive. J. Pharm. Biomed. Anal., 17, 83-88 (1998) 

  3. Blanco, M., Coello, J., Iturriaga, H., Maspoch, S., and PerezMaseda, C., Separation of profen enantiomers by capillary electrophoresis using cyclodextrins as chiral selectors. J. Chromatogr. A, 793, 165-175 (1998a) 

  4. Blanco, M., Cocello, J., Iturriaga, H., Maspoch, S., and PerezMaseda, C., Chiraland nonchiral determination of ketoprofen in pharmaceuticals by capillary zone electrophoresis. J . Chromatogr. A, 799, 301-307 (1998b) 

  5. Blanco, M., Gonzalez, J. M., and Valverde, E. T. I., Enantiomeric purity determination of ketoprofen by capillary electrophoresis: development and validation of the method. Anal. Bioanal. Chem., 375, 157-163 (2003) 

  6. Bhunshan, R. and Martens, J., Resolution of enantiomers of ibuprofen by liquid chromatography. Biomed. Chromatogr., 12, 309-316 (1998) 

  7. Davies, N. M., Method of analysis of chiral-non-steroidal antiinflammatory drugs. J. Chromatogr. B, 691, 229-261 (1997) 

  8. Gareil, F. L. P, Chiral separation of underivatized arylpropionic acids by capillary zone electrophoresis with various cyclodextrins acidity and inclusion constant determinations. J. Chromatogr. A, 735, 311-320 (1996) 

  9. Glowka, F. K. and Karazniewicz, M., Highperformance capillary electrophoresis for determination of enantiomers of 2arylpropionic acid derivatives in human serum pharmacokinetic studies of ketoprofen enantiomers following administration of standard and sustained release tablets. J. Pharm. Biomed. Anal., 35, 807-816 (2004) 

  10. Grubb, N. G., Rudy, D. W., andHall, S. D., Stereoselective highperformance liquid chromatographic analysis of ketoprofen and its acyl glucuronides in chronic renal insufficiency. J. Chromatogr. B, 678, 237-244 (1996) 

  11. Jamali, F. and Wainer, I. W. (Eds.). Drug Stereochemistry. Marcel Dekker Inc., New York, pp. 375-384, (1993) 

  12. Boisvert, J, Caille, G., McGilveray, I. J., and Qureshi, S. A., Quantification of ketoprofen enantiomers in human plasma basedon solid-phase extraction endenantioselective column chromatography: Chiral HPLC column was used. J. Chromatogr. B, 690, 189-193 (1997) 

  13. Kim, K. R., Shim, W. H., Shin Y. J., Park, J., Myung, S. W., and Hong, J., Capillary gas chromatography of acidic nonsteroidal antiinflammatory drugs as tert.-butyldimethylsilyl derivatives. J. Chromatogr., 641, 319-327 (1993) 

  14. Kim, K. R. and Yoon, H. R., Rapid screening for acidic nonsteroidal anti-inflammatory drugs in urine by gas chromatographic- mass spectrometry in the selected-ion monitoring mode. J. Chromatogr. B, 682, 55-66 (1996) 

  15. La, S., Kim, J., Kim, J-H., Goto, J., and Kim, K-R., Simultaneous chiral discrimination of multiples profens by cyclodextrinmodified capillary electrophoresis in normal and reversed polarity modes. Electrophoresis, 24, 2642-2649 (2003) 

  16. Levoin, N., Blondeau, C., Guillaume, G., Grandcolas, L., Chretien, F., Jouzeau, J. Y, Benoit, E., Chapleur, Y, Netter, P., and Lapicque, F., Elucidation of the mechanism of inhibition of cyclooxygenases by acyl-coenzyme A and acylglucuronicconjugatesof ketoprofen. Biochem. Pharmacol., in press (2004) 

  17. Lombardino, J. G., In Lombardino, J. G. (Ed.). Non-steroidal anti-inflammatory drugs. vol. 5, Wiley, New York, pp. 303-345, (1985) 

  18. Lovlin, R., Vakily, M., and Jamali, F., Rapid sensitive and direct chiral high-performance liquid chromatographic method for ketoprofen enantiomers. J. Chromatogr. B, 679, 196-198 (1996) 

  19. Oh, H. S., Lee, Y. S., Kim, H., and Lee, K. P., Formulation and skin permeation characteristics of ketoprofen patches. Yakhak Hoeji, 45, 506-512 (2001) 

  20. Paik, M. J., Lee, Y. S., Goto, J., and Kim, K. R., Chiral discrimination of multiple profens as diastereomeric (R)-(+)-1-phenylethylamides by achiral dual-column gas chromatography. J. Chromatogr. B, 803, 257-265 (2004) 

  21. Paik, M. J. and Kim, K. R., Optical Purity Determination of (S)Ibuprofen in Tablets by Achiral Gas Chromatography. Arch. Pharm. Res., 27, 820-824 (2004) 

  22. Rhee, G. J., Ko, Y. H., Woo, J. S., and Hwang, S. J., Formulation and pharmaceutical properties of transdermal patch of flurbiprofen. Yakhak Hoeji, 43, 447-457 (1999) 

  23. Teng, X. W., Wang, S. W. J., and Davis, N. M., Stereospecific high-performance liquid chromatographic analysis of flurbiprofen: application to pharmacokinetic studies. J. Pharm. Biomed. Anal., 33, 95-100 (2003) 

  24. Tracy, T. S. and Hall, S., Metabolic inversion of (R)-ibuprofen. Epimerization and hydrolysis of ibuprofenyl-coenzyme A. DrugMetabol. Dispos., 20, 322-327 (1992) 

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