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논문 상세정보

EFFECT OF TITANIUM SURFACE ROUGHNESS ON CELL ADHESION OF HUMAN OSTEOBLAST-LIKE CELLS (MG63

Abstract

Statement of problem. The effects of surface roughness have not or insufficiently been analyzed on earlier events such as cell adhesion though cell behavior most germane to implant performance is cell adhesion. Purpose. The purpose of this study was to evaluate cell adhesion of osteoblast-like cells (MG63) onto three types of titanium disks with varying roughness using the Elisa assay. Materials and methods. Representative disks from each group (SLA, HA, machined) were subjected to surface analysis and surface roughness was measured by the optical interferometer (Accura 2000, Intekplus Co., Seoul, Korea). Following this, MG63 cells were cultured on the titanium disks and released. Cell adhesion measurements using the Elisa assay were performed specifically at three points: after 24, 48, and 72 hours of culture. Results. Among the 3 types of surface analyzed, the SLA surface was the roughest with a Ra value of $1.114{\mu}m$ followed by HA coated surface and machined surface, consecutively. The optical density values for the SLA surface group was significantly higher than that of the machined and HA coated surface groups following 24 and 48 hours of culture. The cell culture on HA coated surface showed significantly higher values compared to the machined surface following 24, 48 and 72 hours of culture. Conclusion. The results suggest that surface treatment of titanium surfaces enhanced cell adhesion of human osteoblast-like cells (MG63).

참고문헌 (19)

  1. Branemark P-I. Osseointegration and its experimental background. Journal of Prosthetic Dentistry 1983;50:399-410 
  2. Branemark P-I. Introduction to osseointegration, in Branemark P-I, Zarb GA, AlbrektssonT (eds): Tissue-Integrated Prostheses: Osseointegration in Clinical Dentistry. Chicago, Quintessence Publishing Co, 1985, pp 11-76 
  3. Kasemo B, Lausamm J. Biomaterial and implant surfaces: A surface science approach. International Journal of Oral Maxillofacial Implants 1988;3:247-259 
  4. Stanford CM, Keller JC. Osseointegration and matrix production at the implant surface. Crit Rev Oral BioI Med 1991;2:83-101 
  5. Windeler AS, Bonewald LF, Khare AG, Boyan BD, Mundy GR.The influence of sputtered bone substitutes on cell growth and phenotypic expression. In: The Bone-Biomaterial Interface, J.E. Davies (Ed). Toronto: Toronto Press 1991:205-213 
  6. Martin JY, Schwartz Z, Hummert TW, Schraub DL, Boyan BD. Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63). Journal of Biomedical Materials Research 1995;29:389401 
  7. Boyan BD, Batzer R, Kieswetter K, Liu Y, Cochran DL, Szmuckler-Moncler S, Dean DD, Schwartz Z. Titanium surface roughness alters responsiveness of MG63 osteoblast-like cells to 1$\alpha$,25-(OH)2D3. Journal of Biomedical Materials Research 1998;39:7785 
  8. Bowers KT, Keller JC, Randolph BA, Wick DG, Michaels CM. Optimization of surface micromorphology for enhanced osteoblast responses in vitro. International Journal of Oral and Maxillofacial Implants 1992;7:302-310 
  9. Michaels CM, Keller JC, Stanford CM, Solursh M, Mackenzie IC. In vitro connective tissue cell attachment to cpTi. Journal of Dental Research 1989;68:276 
  10. Boyan BD, Hummert TW, Kieswtter K, Schraub D, Dean DD, Schwartz Z. Effect of titanium surface characteristics on chondrocytes and osteoblasts in vitro. Scanning Electron Microscopy (Cells & Materials) 1995;5:323-335 
  11. Brunette DM. The effects of implant surface topography on the behavior of cells. International Journal of Oral Maxillofacial Implants 1988;3:231-246 
  12. Buser D, Schenk R, Steinemann S, Fiorellini J, Fox C, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. Journal of Biomedical Materials Research 1991;25:889-902 
  13. Davies JE. In vitro modeling of the bone/implant interface. The Anatomical Record 1996;245:426-445 
  14. Davies JE, Lowenberg B, Shiga A. The bone-titanium interface in vitro. Journal of Biomedical Materials Research 1990;24:1289-1306v 
  15. Gotfredsen K, Wennerberg A, Johansson C, Skovgaard LTT, Hjorting-Hansen E. Anchorage of TiO2-blasted, HA-coated, and machined implants: An experimental study with rabbits. Journal of Biomedical Materials Research 1995;29:1223-1231 
  16. Kieswetter K, Schwartz Z, Hummert TW, Cochran DL, Simpson J, Dean DD, Boyan BD. Surface roughness modulates the local production of growth factors and cytokines by osteoblast-like MG63 cells. Journal of Biomedical Materials Research 1996;32:55-63 
  17. Larsson C, Thomsen P, Lausmaa J, Rodahl M, Kasemo B, Ericson LE. Bone response to surface modified titanium implants: studies on electropolished implants with different oxide thicknesses and morphology. Biomaterials 1994;15:1062-1074 
  18. Larsson C, Thomsen P, Aronsson BO, Rodahl M, Lausmaa J, Kasemo B, Ericson LE. Bone response to surface-modified titanium implants: studies on the early tissue response to machines and electropolished implants with different oxide thicknesses. Biomaterials 1996;17:605-616 
  19. Piatelli A, Scarano A, Piatelli M, Calabresse L. Direct bone formation on sand-blasted titanium implants: an experimental study. Biomaterials 1996;17:1015-1018 

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