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The present experimental study was designed to address two issues. The first was to investigate whether oxidation voltage of titanium implants influenced bone tissue responses after an in vivo implantation. The second aim was to investigate secondary stability change after 1 to 3months period. Screw-shaped implants with a wide range of oxide properties were prepared by electrochemical oxidation methods, where the oxide thickness varied in the range of $3-15{\mu}m$. The micro structure revealed pore sizes of $1-3{\mu}m$, the crystal structures of the titanium oxide were amorphous, anatase and a mixture of anatase and rutile type. Bone tissue responses were evaluated by resonance frequency measurements that were undertaken 1 to 3months after insertion in the rabbit tibia. It was concluded that no statistical difference of RFA values was found between the groups, RFA gains after Imonth and 3months were calculated.

참고문헌 (10)

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  3. Larsson, C, Thomsen, P., Aronsson, B.O., Lausmaa, J., Rodahl, M. & Kasemo, B. Bone response to surface-modified titanium implants: studies on the early tissue response to machined and electropolished implants with different oxide thickness. Biomaterials 1996;15:605-616 
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  5. Esposito, M., Lausmaa, J., Hirsch, J.M. & Thomsen, P. Surface analysis of failed oral titanium im-plants. Journal of Biomedical Materials Research 1999;48: 559-568 
  6. Meredith, N., Shagaldi, F., Alleyne, D., Sennerby, L. & Cawley, P. The application of resonance frequency measurements to study the stability of titanium implants during healing in the rabbit tibia. Clinical Oral Implants Research 1997;8:234-243 
  7. Sennerby, L., Thomsen, P. & Ericson, L.E. Ultrastructure of the bone-titanium interface in rabbits. Journal of Materials Science: Materials in Medicine 1992;3:262-271 
  8. Oron, U. & Hazan, R. Method of treating a metal prosthetic device prior to surgical implantation to enhance bone growth relative thereto following implantation. US Patent Number 5 080 671, 1992 
  9. Albrektsson, T., Branemark, P.I., Hansson, H.A., Kasemo, B., Larsson, K., Lindstrom, I., McQueen, D. & Skalak, R. The interface zone of inorganic implants in vivo: titaniumimplants in bone. Annals of Biomedical Engineering 1983;11: 1-27 
  10. McQueen, D., Sundgren, J.E., Ivarsson, B., Lindstrom, I., Ekenstam, B.F., Svensson, A., Albrektsson, T. & Branemark, P.I. Auger electron spectroscopic studies of titanium implants. In: Lee, A.J.C., Albrektsson, T. & Branemark, P.I., eds. Clinical Applications of Biomaterials, 1982;179-185. New York: John Wiley & Sons 

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