[논문]A Proposal for Optical Diagnostics Through the Enhancement of Diffraction Patterns Using Thin-film Interference Filters

Stefanita Carmen Gabriela; Shao Yun Feng

doi:10.1007/bf02933481

A Proposal for Optical Diagnostics Through the Enhancement of Diffraction Patterns Using Thin-film Interference Filters 원문보기

Biotechnology and bioprocess engineering : Bbe, v.9 no.6, 2004년, pp.428 - 434

Stefanita Carmen Gabriela (University of Alberta, Department of Electrical and Computer Engineering Edmonton) , Shao Yun Feng (University of Alberta, Department of Electrical and Computer Engineering Edmonton)

Abstract ▼ AI-Helper

Coarse clumping of solid materials within diseased biological cells can have a marked influence on the light scattering pattern. Perturbations in refractive index lead to distinct variations in the cytometric signature, especially apparent over wide scattering angles. The large dynamic range of scattering intensities restricts collection of data to narrow angular intervals believed to have the highest potential for medical diagnosis. We propose the use of an interference filter to reduce the dynamic range. Selective attenuation of scattering intensity levels is expected to allow simultaneous data collection over a wide angular interval. The calculated angular transmittance of a commercial shortwave-pass filter of cut-off wavelength 580 nm indicates significant attenuation of scattering peaks below ${\~}\;10^{circ}$, and reasonable peak equalization at higher angles. For the three-dimensional calculation of laser light scattered by cells we use a spectral method code that models cells as spatially varying dielectrics, stationary in time. However, we perform preliminary experimental testing with the interference filter on polystyrene microspheres instead of biological cells. A microfluidic toolkit is used for the manipulation of the microspheres. The paper intends to illustrate the principle of a light scattering detection system incorporating an interference filter for selective attenuation of scattering peaks.

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The proposed optical device is intended for single cell analysis. Consequently, using the μTK was necessary to ensure physical separation of the objects subjected to analysis, in this case polystyrene microspheres.

참고문헌 (22)

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DOI : 10.1007/BF02933481 [무료]
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