$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a disper­sion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the formation of colloidal microparitcles, various solvents like ethanol, DMF, DMAc, and acetone were used. The rosin microparticles containing IND were characterized by X­ray differactometry (XRD) and differential scanning calorimetry (DSC). The morphologies of rosin microparticles observed by scanning electron microscopy (SEM) were spherical. The solvents used to dissolve rosin significantly affected the drug content and drug release rate of IND. The release behaviors of IND from the rosin microparticles were dependent on the drug content and size of the particles. Rosin micorparticles with a higher drug content and of a larger particle size had a slower drug release rate. Also, the IND release rate from the rosin microparticles could be regulated by the rosin content in the microparticles. From these results, rosin microparticles have the potential of being used as a sustained release system of IND.

참고문헌 (23)

  1. Ramani, C. C., P. K. Puranik, and A. K. Dorle (1996) Study of diabietic acid as matrix forming material. Int. J. Pharm. 137: 11-19 
  2. Yeo, Y., N. J. Baek, and K. N. Park (2001) Microencapsulation methods for delivery of protein drugs. Biotechnol. Bioprocess Eng. 6: 213-230 
  3. Jung, S. W., Y. I. Jeong, and S. H. Kim (2003) Charac-terization of hydrophobized pullulan with various hydro-phobicities. Int. J. Pharm. 254: 109-121 
  4. Wilhelm, M., C. L. Zhao, Y. Wang, R. Xu, M. A. Winnik, J. L. Mura, G. Riess, and M. D. Croucher (1991) Poly (styrene-ethylene oxide) block copolymer micelle formation in water: A fluorescence probe study. Macromolecules 24: 1033-1040 
  5. Jeong, Y. I., J. B. Cheon, S. H. Kim, J. W. Nah, Y. M. Lee, Y. K. Sung, T. Akaite, and C. S. Cho (1998) Clonazepam release from core-shell type microparticles in vitro. J. Control. Release 51: 169-178 
  6. Kown, G. S., M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka (1995) Physical entrapment of adriamycin in AB block copolymer micelles. Pharm. Res. 12: 192-195 
  7. Mandaogade, P. M., P. M. Satturwar, S. V. Fulzele, B. B. Gogte, and A. K. Dorle (2002) Rosin derivatives: Novel film forming materials for controlled drug delivery. Reactive Func. Polymers 50: 233-242 
  8. Fulzele, S. V., P. M. Satturwar, and A. K. Dorle (2002) Polymerized rosin: Novel film forming polymer for drug delivery. Int. J. Pharm. 249: 175-84 
  9. Eis, M. J., B. M. Watkins, A. Philip, and R. E. Welling (1998) Non-steroidal-induced benign structures of colon: A case report and review of the literature. Am. J. Gastroenterol. 93: 120-121 
  10. Kim, S. Y., I. G. Shin, and Y. M. Lee (1999) Amphiphilic diblock copolymeric nanospheres composed of methoxy poly(ethylene glycol) and glycolide: Properties, cytotoxicity and drug release behavior. Biomaterials 20: 1033-1042 
  11. La, S. B., T. Okano, and K. Kataoka (1996) Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly(ethylene oxide)-poly ( -benzyl L-aspartate) block copolymer micelles. J. Pharm. Sci. 85: 85-90 
  12. Joseph, I. and S. Venkatoran (1995) Indomethacin sustained release from alginate-gelatin or pectin-gelatin coacervates. Int. J. Pharm. 126: 161-168 
  13. Jeon, H. J., Y. I. Jeong, M. K. Jang, Y. H. Park, and J. W. Nah (2000) Effect of solvent on the preparation of surfactant-free poly(DL-lactide-co-glycolide) nano-particles and norfloxacin release characteristics. Int. J. Pharm. 207: 99-108 
  14. Gref, R., Y. Minamitake, M. T. Peracchia, V. Trubetskoy, V. Torchilin, and R. Langer (1994) Biodegradable long-cir-culating polymeric nanospheres. Science 263: 1600-1603 
  15. Uzunkaya, G. and N. Bergisadi (2003) In vitro drug liberation and kinetics of sustained release indomethacin suppository. Il Farmaco 58: 509-512 
  16. Khanfar, M. S., N. M. Najib, and G. K. Pillai (1997) Dissolution behaviour of sustained release formulation of indomethacin with Eudragit RS. Acta Pharm. Hung. 67: 235-239 
  17. Puranik, P. K. and A. K. Dorle (1991) Study of a abietic acid-glycerol derivatives as microencapsulating materials. J. Microencapsulation 8: 247-252 
  18. Kam, S. H., E. S. Park, and S. C. Chi (1995) Skin Permeation of indomethacin from Gels. J. Kor. Pharm. Sci. 25: 129-136 
  19. Fulzele, S. V., P. M. Satturwar, and A. K. Dorle (2003) Study of the biodegradation and in vivo biocompatibility of novel biomaterials. Eur. J. Pharm. Sci. 20: 53-61 
  20. Lee, C. M., D. W. Kim, H. C. Lee, and K. Y. Lee, (2004) Pectin microspheres for oral colon delivery: Preparation using spray drying method and in vitro release of indomethacin. Biotechnol. Bioprocess Eng. 9: 191-195 
  21. Flower, R. J. (1994) Drugs which inhibit prostaglandin biosynthesis. Pharm. Rev. 26: 33-67 
  22. Karasulu, E., H. Y. Karasulu, G. Ertan, L. Kirilmaz, and T. Guneri (2003) Extended release lipophilic indomethacin microspheres: Formulation factors and mathematical equations fitted drug release rates. Eur. J. Pharm. Sci. 19: 9-104 
  23. Na, K., Y. E. Kim, and K. Y. Lee, (1999) Preparation of microparticles in drug delivery system using guar derivatives and dialysis method. J. Microbiol. Biotechnol. 9: 50-55 

이 논문을 인용한 문헌 (1)

  1. 2005. "" Biotechnology and bioprocess engineering, 10(6): 516~521 

원문보기

원문 PDF 다운로드

  • ScienceON :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일