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Rosin Microparticles as Drug Carriers: Influence of Various Solvents on the Formation of Particles and Sustained-release of Indomethacin 원문보기

Biotechnology and bioprocess engineering : Bbe, v.9 no.6, 2004년, pp.476 - 481  

Lee Chang Moon (Interdisciplinary Program of Biomedical Engineering, Chonnam National University) ,  Lim Seung (Ecobio Inc., Business Incubation Center, Chonnam National University) ,  Kim Gwang Yun (Ecobio Inc., Business Incubation Center, Chonnam National University) ,  Kim Do Man (School of biological Sciences and Technology and Research Institute for Catalysis, Chonnam National University) ,  Kim Dong Woon (Department of Health and Hygiene, Gwang-Yang Health College) ,  Lee Hyun Chul (Department of Microbiology, Chonnam National University Medical School) ,  Lee Ki Young (Department of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University)

Abstract ▼ AI-Helper 아이콘AI-Helper

The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a disper­sion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the form...

주제어

#rosin gum   #indomethacin   #sustained release   #microparticle  

AI 본문요약
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제안 방법

  • One of the characteristic points of this study was to investigate the influence of various organic solvents on the formation of microparticles without the addition of surfactant. Ethanol, acetone, DMF and DMAc were selected from various organic solvents, and the studies for the influence of these solvents were performed in the condition of a rosin to IND ratio of 200:100. All presented organic solvents were observed to form a microparticle without the addition of surfactant (Fig.
  • In order to investigate the crystallinity of the polymer, X-ray diffractograms were obtained using a Rigaku D/ Max-1200 (Rigaku, Japan) with Ni-filtered Cu Ka radiation (40 kY 30 mA). The instrument was operated in the step scan mode with an increment of 0.
  • One of the characteristic points of this study was to investigate the influence of various organic solvents on the formation of microparticles without the addition of surfactant. Ethanol, acetone, DMF and DMAc were selected from various organic solvents, and the studies for the influence of these solvents were performed in the condition of a rosin to IND ratio of 200:100.
  • The XRD and DSC analyses were used to investigate the physicochemical characteristics of rosin and IND in the microparticles (Figs. 2 and 3). During the formulation of particles, hydrophobic drug, IND, could be incorporated in the rosin microparticles because it is completely soluble in the polymer solution [2, 3].
  • The aim of this study was to prepare rosin microparticles containing IND for the sustained release of this drug, and to evaluate this release through in vitro dissolution tests. Furthermore, the influence of various organic solvents used in the preparation of the rosin microparticles was investigated for their affect on formulation, drug content, and drug release.
  • Rosin microparticles were prepared by a dispersion and dialysis method without the addition of surfactant and their physicochemical characteristics, such as particle shape, drug content and drug release rate were investigated against various solvents used for the preparation of microparticles. The particle shape and drug content of rosin microparticles were changed by the various solvents (Lh., ethanol, DMF, DMAc and acetone) used in the test. The morphological shape of the rosin microparticles prepared with ethanol as a solvent was uniform and smaller than those formed with the other solvents.
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참고문헌 (23)

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    상세보기 crossref

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