$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
안녕하세요!
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

Abstract

The cytotoxic activities of Cinnamomum cassia (Blume) bark-derived materials toward six human HeLa epithelioid cervix, A549 lung, SK-OV-3 ovarian, SK-MEL-2 melanoma, XF-498 central nerve system, and HCT-15 colon tumor cell lines were evaluated by using sulforhodamine B assay and compared to those of the anticancer agents, cisplatin and mitomycin C. The biologically active constituent of the Cinnamomum bark was characterized as trans­cinnamaldehyde by spectroscopic analysis. The cytotoxic activity of cinnamaldehyde against HeLa, SK-MEL-2, and HCT -15 cell lines was comparable to that of cisplatin and mitomycin C. The compound showed lower activity against A549, SK-OV-3, and XF-498 cell lines than the anticancer agents. Eugenol exhibited moderate activity against SK-OV­3, XF-498, and HCT-15 tumor cells, and trans-cinnamic acid, cinnamyl alcohol, $\alpha-pinene,\;and\;\beta-pinene$ showed little or no activity against model tumor cells. Cinnamaldehyde was not mutagenic against four strains (TA 98, TA 100, TA 1535, and TA 1537) of Salmonella typhimurium (Castel and Chalm). These results indicate at least one pharmacological action of C. cassia.

참고문헌 (29)

  1. Bokkenheuser, V. D. and J. Winter. 1983. Biotransformation of steroids, pp. 215-239. In D. J. Hentges (ed.). Human Intestinal Microflora in Health and Disease. Academic, New York, U.S.A 
  2. Goidin, A., A. A. Serpick, and N. Mantel. 1966. Experimental screening procedures and clinical predictability value. Cancer Chemoth. Rep. 50: 190-231 
  3. Goldman, P. 1983. Biochemical pharmacology and toxicology involving the intestinal flora, pp. 241-263. In D. J. Hentges (ed.). Human Intestianl Microflora in Health and Disease. Academic, New York, U.S.A 
  4. Lee, H. S. 2003. Inhibitory effects of quinizarin isolated from Cassia tora seeds against human intestinal bacteria and aflatoxin B$_1$ biotransformation. J. Microbiol. Biotechnol. 13(4): 529-536 
  5. Lee, H. S. and Y. J. Ahn. 1998. Growth-inhibiting effects of Cinnamomum cassia bark-derived materials on human intestinal bacteria. J. Agric. Food Chem. 46: 8-12. 
  6. Maron, D. M. and B. N. Ames. 1983. Revised methods for the Salmonella mutagenicity test. Mut. Res. 113: 173-215 
  7. Namba, T. 1993. The Encyclopedia of Wakan-Yaku (Traditional Sino-Japanese Medicines) with Color Pictures. Hoikusha, Osaka, Japan 
  8. Yi, H. J., J. Y. Kim, K. H. Kim, H. J. Lee, and H. J. Lee. 2003. Anticancer activity of peptide fractions from egg white hydrolysate against mouse lymphoma cells. Food Sci. Biotechnol. 12: 224-227 
  9. Cassady, J. M. and J. D. Douros. 1980. Anticancer Agents Based on Natural Product Models. Academic, New York, U.S.A 
  10. Barclay, A. S. and R. E. Jr. Perdue. 1976. Distribution of anticancer activity in higher plants. Cancer Treat. Rep. 50: 1081-1113 
  11. Oguni, I., K. Nasu, J. Oguni, S. Kanaya, H. Tachikawa, M. Fujino, Y. Oishi, Y. Ohta, M. Usami, and T. Masuki. 1983. On the regional difference in the mortality of cancer for cities, towns and villages in Shizuoka Prefecture (1971- 1978). Ann. Rep. Shizuoka Womens Coll. 29: 49-93 
  12. Park, J. W., B. S. Song, D. Ryu, C. Lee, and Y. B. Kim. 2002. In vitro bactericidal and anticancer activity of new metabolite, ARK42, isolated from Aspergillus repens K42. J. Microbiol. Biotechnol. 12(6): 1017-1021 
  13. Piantadosi, C., V. G. Skulason, J. L. Irvin, J. M. Powell, and L. Hall. 1964. Potential antitumor agents. Schiffbases and hydrazone derivatives of pyrimidine-4-carboxaldehyde. J. Med. Chem. 7: 337-348 
  14. Finegold, S. M., D. J. Flora, H. R. Attebery, and V. L. Sutter. 1975. Fecal bacteriology of colonic polyp patients and control patients. Cancer Res. 35: 3407-3417 
  15. Fujisawa, T., M. Kuno, T. Kokuba, R. Hirata, K. Sasaki, Y. Fujisawa, K. Nakamura, and T. Mitsuoka. 1992. Effects of apple and corn fiber supplemented with bifidobacteria and fructooligosaccharides preparation (A & C) on the fecal microflora and fecal properties in patients with dementia senilis. Bifidus. 5: 173-176 
  16. Kuwata, K., Y. Fujita, T. Yamane, Y. Sagara, M. Tanaka, J. Okuzumi, T. Takahashi, H. Fujiki, and T. Okuda. 1988. Anti-promotive effect of epigallocatechin gallate in the process of mouse duodenal carcinogenesis of ENNG, pp. 208. Proc. Ann. Meeting Jpn Soc. Cancer Res. Tokyo 
  17. Jeong, I. H., C. O. Lee, C. S. Kim, S. U. Kim, and Y. J. Ahn. 2000. Cytotoxic activity of medicinal plant extracts against human tumor cell lines. Agric. Chem. Biotech. 43: 59-61 
  18. Lee, K. D., K. H. Park, H. Kim, J. Kim, Y. S. Rim, and M. S. Yang. 2003. Cytotoxic activity and structural analogues of guaianolide derivatives from the flower of Chrysanthemum coronarium L. Agric. Chem. Biotech. 46: 29-32 
  19. Okubo, T., N. Ishihara, A. Oura, M. Serit, M. Kim, T. Yamamoto, and T. Mitsuoka. 1992. In vivo effects of tea polyphenol intake on human intestinal micorflora and metabolism. Biosci. Biotechnol. Biochem. 56: 588-591 
  20. Skehan, P., R. Storeng, D. A. Scudiero, A. Monks, J. B. McMahon, D. T. Visca, J. T. Warren, H. Bokesch, S. Kenney, and M. R. Boyd. 1990. New colorimetric cytotoxicity assay for anticancer drug screening. J. Natl. Cancer Inst. 82: 1107-1112 
  21. Ahn, Y. J., C. O. Lee, J. H. Kweon, J. W. Ahn, and J. H. Park. 1998. Growth-inhibitory effects of Galla Rhoisderived tannins on intestinal bacteria. J. Appl. Microbiol. 84: 439-443 
  22. Colegate, S. M. and J. J. Molyneux. 1993. Bioactive Natural Products: Detection, Isolation and Structure Determination. CRC, Boca Raton 
  23. Mitsuoka, T. 1981. Intestinal Flora and Carcinogenesis. Japan Scientific Society Press, Tokyo, Japan 
  24. Van der Bliek, A. M. and P. Borst. 1986. Multidrug resistance. Adv. Cancer Res. 52: 165-204 
  25. Ahn, Y. J., T. Kawamura, M. Kim, T. Yamamoto, and T. Mitsuoka. Tea polyphenols: Selective growth inhibitors of Clostridium spp. Agri. Biol. Chem. 55: 1425-1426 
  26. Kinghorn, A. D. and M. F. Balandrin. 1993. Human Medicinal Agents from Plants. ACS Symposium Series 534, American Chemical Society, Washington, D.C., U.S.A 
  27. FAO/WHO. Specifications for the identity and purity of food additives and their toxicological evaluation: Some flavoring substances and non-nutritive sweetening agents. Eleventh Report of the Joint FAO/WHO Expert Committee on Food Additives. FAO Nutrition Meetings Report Series No. 44, Wld Hlth Org. Techn. Rep. Ser. No. 383, 1968 
  28. Buckingham, J. 1992. Dictionary of Natural Products. Chapman & Hall, London 
  29. Malpas, J. S. 1991. Chemotheraphy, pp. 451-469. In: L. M. Franks, and N. M. Teich (eds.). Introduction to the Cellular and Molecular Biology of Cancer. Oxford University Press, Oxford, U.K 

이 논문을 인용한 문헌 (2)

  1. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(5): 443~447 
  2. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(5): 480~485 

원문보기

원문 PDF 다운로드

  • ScienceON :
  • KCI :

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일