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Abstract

In a previous study by the current authors, hepatocellular carcinoma (HCC) was determined to be epidemiologically sex-dependent, and the incidence and multiplicity of HCC found to decrease in estradiol-3 benzoate (EB)-treated F344 rats. Therefore, to ascertain the anticancer mechanism of EB, a commercially available cDNA microarray, with a total of 14,815 cDNA rat gene clones, was used to determine the differentially expressed genes in nontreated livers, EB-treated livers, and diethynitrosolamine (DEN)-induced HCC. In the sequenced experiment, a total of 85 genes were differentially expressed at either two or more times the rate of the normal expression, where 33 genes were downregulated by EB, and 52 genes upregulated. Candidate genes were selected according to significant changes observed in the mRNA expression in the EB-treated livers compared with the nontreated livers, then these genes were filtered according to their different expression patterns in the DEN-induced tumors compared to the estrogen-treated livers. To confirm the microarray data, a real-time PCR analysis was performed for ten selected genes: the H-ras revertant protein 107 (H­rev107), insulin-like growth factor binding protein (lOFBP), parathyroid hormone receptor (PI'HR), SH3 domain binding protein (SH3BP), metallothionein, src-suppressed C-kinase substrate (SSeCK) gene, phosphodiesterase I, CD44, epithelial membrane protein 3 (EMP3), and estrogen receptor a (ERa). The SSeCK and phosphodiesterase I genes were both upregulated in the DEN-induced hepatocarcinomas, yet their possible carcinogenic functions remain unknown. Meanwhile, the other genes were downregulated, including the genes related to growth regulation (IOFBP, H-revI07, ER$\alpha$), adipogenesis inhibition (PTHR), and tumor suppression (metallothionein).

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참고문헌 (35)

  1. Fillit, H., H. Weinreb, I. Cholst, V. Luine, B. McEwen, R. Amador, and J. Zabriskie. 1986. Observations in a preliminary open trial of estradiol therapy for senile dementia-Alzheimer’s type. Psychoneuroendocrinology 11: 337-345 
  2. La Vecchia, C., E. Negri, L. Cavalieri d’Oro, and S. Franceschi. 1998. Liver cirrhosis and the risk of primary liver cancer. Eur. J. Cancer Prev. 7: 315-320 
  3. Matsuura, B., Y. Taniguchi, and Y. Ohta. 1994. Effect of antiandrogen treatment on chemical hepatocarcinogenesis in rats. J. Hepatol. 21: 187-193 
  4. Sylvia, V. L., T. Hughes, D. D. Dean, B. D. Boyan, and Z. Schwartz. 1998. 17beta-estradiol regulation of protein kinase C activity in chondrocytes is sex-dependent and involves nongenomic mechanisms. J. Cell Physiol. 176:435-444 
  5. Xu, J. W., J. Gong, X. M. Chang, J. Y. Luo, L. Dong, Z. M. Hao, A. Jia, and G. P. Xu. 2002. Estrogen reduces CCL4-induced liver fibrosis in rats. World J. Gastroenterol. 8: 883-887 
  6. Kemp, C. J. and N. R. Drinkwater. 1989. Genetic variation in liver tumor susceptibility, plasma testosterone levels, and androgen receptor binding in six inbred strains of mice. Cancer Res. 49: 5044-5047 
  7. Dang, Z. C., R. L. van Bezooijen, M. Karperien, S. E. Papapoulos, and C. W. Lowik. 2002. Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J. Bone Miner. Res. 17: 394-405 
  8. Paassilta, M., A. Karjalainen, K. Kervinen, M. J. Savolainen, J. Heikkinen, A. C. Backstrom, and Y. A. Kesaniemi. 2000. Insulin-like growth factor binding protein-1 (IGFBP-1) and IGF-I during oral and transdermal estrogen replacement therapy: Relation to lipoprotein(a) levels. Atherosclerosis 149: 157-162 
  9. Stefan, C., W. Stalmans, and M. Bollen. 1996. Threonine autophosphorylation and nucleotidylation of the hepatic membrane protein PC-1. Eur. J. Biochem. 241: 338-342 
  10. Cai, L., C. J. Wang, Z. L. Xu, D. X. Deng, S. Chakrabarti, and M. G. Cherian. 1998. Metallothionein and apoptosis in primary human hepatocellular carcinoma from northern China. Anticancer Res. 18: 4667-4672 
  11. Choi, J. Y., M. Kim, and J. H. Lee. 2002. Reevaluation of the change of leuconostoc species and Lactobacillus plantarum by PCR during kimchi fermentation. J. Microbiol. Biotechnol. 12: 166-171 
  12. Segars, J. H. and P. H. Driggers. 2002. Estrogen action and cytoplasmic signaling cascades. Part I: Membraneassociated signaling complexes. Trends Endocrinol. Metab. 13: 349-354 
  13. Shimizu, I., M. Yasuda, Y. Mizobuchi, Y. R. Ma, F. Liu, M. Shiba, T. Horie, and S. Ito. 1998. Suppressive effect of oestradiol on chemical hepatocarcinogenesis in rats. Gut 42: 112-119 
  14. Ramirez, V. D. and J. Zheng. 1996. Membrane sex-steroid receptors in the brain. Front. Neuroendocrinol. 17: 402- 439 
  15. Cicchetti, P., A. J. Ridley, Y. Zheng, R. A. Cerione, and D. Baltimore. 1995. 3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts. EMBO J. 14: 3127-3135 
  16. Deng, D. X., S. Chakrabarti, M. P. Waalkes, and M. G. Cherian. 1998. Metallothionein and apoptosis in primary human hepatocellular carcinoma and metastatic carcinoma. Histopathology 32: 348-355 
  17. Lin, X., P. Nelson, and I. H. Gelman. 2000. SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G13S progression by controlling the expression and cellular compartmentalization of cyclin D. Mol. Cell. Biology 20: 7259-7272 
  18. Sawaki, M., K. Enomoto, H. Takahashi, Y. Nakajima, and M. Mori. 1990. Phenotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats. Carcinogenesis 11: 1857-1861 
  19. Weber, G. F., R. T. Bronson, J. Ilagan, H. Cantor, R. Schmits, and T. W. Mak. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res. 62: 2281-2286 
  20. Jeoung, D., J. H. Kim, Y. H. Lee, M. Baek, S. Lee, N. I. Baek, and H. Y. Kim. 2002. cDNA microarray analysis of transcriptional response to hyperin in human gastric cancer cells. J. Microbiol. Biotechnol. 12: 664-668 
  21. Colditz, G. A., K. M. Egan, and M. J. Stampfer. 1993. Hormone replacement therapy and risk of breast cancer: Results from epidemiologic studies. Am. J. Obstet. Gynecol. 168: 1473-1480 
  22. Even, C., G. Launoy, T. Collet, O. Duval, M. A. Piquet, A. Rougereau, J. C. Verwaerde, and T. Dao. 1997. Epidemiology of hepatocellular carcinoma in the department of Calvados. Gastroenterol. Clin. Biol. 21: 450-458 
  23. Horwitz, K. B., Y. Koseki, and W. L. McGuire. 1978. Estrogen control of progesterone receptor in human breast cancer: Role of estradiol and antiestrogen. Endocrinology 103: 1742-1751 
  24. Watson, P. H., L. J. Fraher, G. N. Hendy, U. I. Chung, M. Kisiel, B. V. Natale, and A. B. Hodsman. 2000. Nuclear localization of the type 1 PTH/PTHrP receptor in rat tissues. J. Bone Miner. Res. 15: 1033-1044 
  25. Pizzuti, A., L. Frittitta, A. Argiolas, R. Baratta, I. D. Goldfine, M. Bozzali, T. Ercolino, G. Scarlato, L. Iacoviello, R. Vigneri, V. Tassi, and V. Trischitta. 1999. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 48: 1881-1884 
  26. Yu, M. C., J. M. Yuan, S. Govindarajan, and R. Ross. 2000. Epidemiology of hepatocellular carcinoma. Can. J. Gastroenterol. 14: 703-709 
  27. Roder, K., K. H. Kim, and H. S. Sul. 2002. Induction of murine H-rev107 gene expression by growth arrest and histone acetylation: Involvement of an Sp1/Sp3-binding GCboxq. Biochem. Biophys. Res. Commun. 294: 63-70 
  28. Erdstein, J., S. Wisebord, S. Y. Mishkin, and S. Mishkin. 1989. The effect of several sex steroid hormones on the growth rate of three Morris hepatoma tumor lines. Hepatology 9: 621-624 
  29. Nelson, P. and I. H. Gelman. 1997. Cell-cycle regulated expression and serine phosphorylation of the myristylated protein kinase C substrate, SSeCKS: Correlation with cell confluency, G0 phase and serum response. Mol. Cell. Biochem. 175: 233-241 
  30. Yue, S. Q., Y. L. Yang, K. F. Dou, and K. Z. Li. 2003. Expression of PCNA and CD44 mRNA in colorectal cancer with venous invasion and its relationship to liver metastasis. World J. Gastroenterol. 9: 2863-2865 
  31. Henderson, B. E., R. K. Ross, A. Paganini-Hill, and T. M. Mack. 1986. Estrogen use and cardiovascular disease. Am. J. Obstet. Gynecol. 154: 1181-1186 
  32. Hoe, H. S., I. G. Jo, H. J. Shin, H. J. Jeon, H. K. Kim, J. S. Lee, Y. S. Kim, D. S. Lee, and S. T. Kwon. 2003. Cloning and expression of the gene for inorganic pyrophosphatase of Thermus caldophilus GK24 and properties of the enzyme. J. Microbiol. Biotechnol. 13: 139-145 
  33. Mishkin, S. Y., E. Farber, R. K. Ho, S. Mulay, and S. Mishkin. 1983. Evidence for the hormone dependency of hepatic hyperplastic nodules: Inhibition of malignant transformation after exogenous 17 beta-estradiol and tamoxifen. Hepatology 3: 308-316 
  34. Turner, R. T., B. L. Riggs, and T. C. Spelsberg. 1994. Skeletal effects of estrogen. Endocr. Rev. 15: 275-300 
  35. Mackay, A., C. Jones, T. Dexter, R. L. Silva, K. Bulmer, A. Jones, P. Simpson, R. A. Harris, P. S. Jat, A. M. Neville, L. F. Reis, S. R. Lakhani, and M. J. O’Hare. 2003. cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells. Oncogene 22: 2680-2688 

이 논문을 인용한 문헌 (2)

  1. 2006. "" Journal of microbiology and biotechnology, 16(12): 1841~1848 
  2. 2006. "" Journal of microbiology and biotechnology, 16(8): 1292~1300 

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