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Abstract

This study describes the purification and characterization of a novel antihypertensive angiotensin 1­converting enzyme (ACE) inhibitory peptide from Saccharomyces cerevisiae. Maximal production of the ACE inhibitor from Saccharomyces cerevisiae was obtained from 24 h of cultivation at $30^{\circ}C$ and its ACE inhibitory activity was increased by about 1.5 times after treatment of the cell-free extract with pepsin. After the purification of ACE inhibitory peptides with ultrafiltration, Sephadex G-25 column chromatography, and reverse-phase HPLC, an active fraction with an $IC_{50}$ of 0.07 mg and $3.5\%$ yield was obtained. The purified peptide was a novel decapeptide, showing very low similarity to other ACE inhibitory peptide sequences, and its amino acid sequence was Tyr-Asp-Gly-Gly-Val-Phe-Arg-Val-Tyr-Thr. The purified inhibitor competitively inhibited ACE and also showed a clear antihypertensive effect in spontaneously hypertensive rats (SHR) at a dosage of 1 mg/kg body weight.

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  3. Jang, Jeong-Hoon ; Kim, Jae-Ho ; Kim, Na-Mi ; Kim, Ha-Kun ; Lee, Jong-Soo 2010. "Production of Bioactive Compounds from Fungi Grown on Ginseng-Steaming Effluent" 한국미생물·생명공학회지 = Korean journal of microbiology and biotechnology, 38(2): 129~135 
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  6. Jang, In-Taek ; Kim, Young-Hun ; Yi, Sung-Hun ; Lim, Sung-Il ; Lee, Jong-Soo 2011. "Screening of a New Fibrinolytic Substances-Producing Yeast" 한국균학회지 = The Korean journal of mycology, 39(3): 227~228 
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  9. Baek, Seung-Ye ; Nam, Yun-Gyu ; Ju, Jung-Il ; Lee, Jong-Soo 2011. "Changes of Quality Characteristics during Storage of Gugija-Liriope tuber Makgeolli Made by Saccharomyces cerevisiae C-2" 한국균학회지 = The Korean journal of mycology, 39(2): 122~125 
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  11. Jang, In-Taek ; Kim, Young-Hun ; Kang, Min-Gu ; Yi, Sung-Hun ; Lim, Sung-Il ; Lee, Jong-Soo 2012. "Production of Tyrosinase Inhibitor from Saccharomyces cerevisiae" 한국균학회지 = The Korean journal of mycology, 40(1): 60~64 
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  13. Min, Jin Hong ; Lee, Hyang Burm ; Lee, Jong Soo ; Kim, Ha Kun 2013. "Identification of Yeasts Isolated from Wild Flowers Collected in Coast Areas of Korea Based on the 26S rDNA Sequences" 한국균학회지 = The Korean journal of mycology, 41(3): 185~191 
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  15. 2014. "" 한국균학회지 = The Korean journal of mycology, 42(2): 170~173 
  16. Kim, Young-Hun ; Shin, Ja-Won ; Lee, Jong-Soo 2014. "Production and Anti-hyperglycemic Effects of ${\alpha}$-Glucosidase Inhibitor from Yeast, Pichia burtonii Y257-7" 한국미생물·생명공학회지 = Korean journal of microbiology and biotechnology, 42(3): 219~224 

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