Shigellosis is a global human health problem. Four species of Shigella i.e. S. dysenteriae, S. flexneri, S. boydii and S. sonnei are able to cause the disease. These species are subdivided into serotypes on the basis of O-specific polysaccharide of the LPS. Shigella dysenteriae type 1 produces sever...
Shigellosis is a global human health problem. Four species of Shigella i.e. S. dysenteriae, S. flexneri, S. boydii and S. sonnei are able to cause the disease. These species are subdivided into serotypes on the basis of O-specific polysaccharide of the LPS. Shigella dysenteriae type 1 produces severe disease and may be associated with life-threatening complications. The symptoms of shigellosis include diarrhoea and/or dysentery with frequent mucoid bloody stools, abdominal cramps and tenesmus. Shigella spp. cause dysentery by invading the colonic mucosa. Shigella bacteria multiply within colonic epithelial cells, cause cell death and spread laterally to infect and kill adjacent epithelial cells, causing mucosal ulceration, inflammation and bleeding. Transmission usually occurs via contaminated food and water or through person-to-person contact. Laboratory diagnosis is made by culturing the stool samples using selective/differential agar media. Shigella spp. are highly fragile organism and considerable care must be exercised in collecting faecal specimens, transporting them to the laboratories and in using appropriate media for isolation. Antimicrobial agents are the mainstay of therapy of all cases of shigellosis. Due to the global emergence of drug resistance, the choice of antimicrobial agents for treating shigellosis is limited. Although single dose of norfloxacin and ciprofloxacin has been shown to be effective, they are currently less effective against S. dysenteriae type 1 infection. Newer quinolones, cephalosporin derivatives, and azithromycin are the drug of choice. However, fluoroquinolone-resistant S. dysenteriae type 1 infection have been reported. Currently, no vaccines against Shigella infection exist. Both live and subunit parenteral vaccine candidates are under development. Because immunity to Shigella is serotype-specific, the priority is to develop vaccine against S. dysenteriae type 1 and S. flexneri type 2a. Shigella species are important pathogens responsible for diarrhoeal diseases and dysentery occurring all over the world. The morbidity and mortality due to shigellosis are especially high among children in developing countries. A recent review of literature (KotIoff et al.,1999) concluded that, of the estimated 165 million cases of Shigella diarrhoea that occur annually, $99\%$ occur in developing countries, and in developing countries $69\%$ of episodes occur in children under five years of age. Moreover, of the ca.1.1 million deaths attributed to Shigella infections in developing countries, $60\%$ of deaths occur in the under-five age group. Travellers from developed to developing regions and soldiers serving under field conditions are also at an increased risk to develop shigellosis.
Shigellosis is a global human health problem. Four species of Shigella i.e. S. dysenteriae, S. flexneri, S. boydii and S. sonnei are able to cause the disease. These species are subdivided into serotypes on the basis of O-specific polysaccharide of the LPS. Shigella dysenteriae type 1 produces severe disease and may be associated with life-threatening complications. The symptoms of shigellosis include diarrhoea and/or dysentery with frequent mucoid bloody stools, abdominal cramps and tenesmus. Shigella spp. cause dysentery by invading the colonic mucosa. Shigella bacteria multiply within colonic epithelial cells, cause cell death and spread laterally to infect and kill adjacent epithelial cells, causing mucosal ulceration, inflammation and bleeding. Transmission usually occurs via contaminated food and water or through person-to-person contact. Laboratory diagnosis is made by culturing the stool samples using selective/differential agar media. Shigella spp. are highly fragile organism and considerable care must be exercised in collecting faecal specimens, transporting them to the laboratories and in using appropriate media for isolation. Antimicrobial agents are the mainstay of therapy of all cases of shigellosis. Due to the global emergence of drug resistance, the choice of antimicrobial agents for treating shigellosis is limited. Although single dose of norfloxacin and ciprofloxacin has been shown to be effective, they are currently less effective against S. dysenteriae type 1 infection. Newer quinolones, cephalosporin derivatives, and azithromycin are the drug of choice. However, fluoroquinolone-resistant S. dysenteriae type 1 infection have been reported. Currently, no vaccines against Shigella infection exist. Both live and subunit parenteral vaccine candidates are under development. Because immunity to Shigella is serotype-specific, the priority is to develop vaccine against S. dysenteriae type 1 and S. flexneri type 2a. Shigella species are important pathogens responsible for diarrhoeal diseases and dysentery occurring all over the world. The morbidity and mortality due to shigellosis are especially high among children in developing countries. A recent review of literature (KotIoff et al.,1999) concluded that, of the estimated 165 million cases of Shigella diarrhoea that occur annually, $99\%$ occur in developing countries, and in developing countries $69\%$ of episodes occur in children under five years of age. Moreover, of the ca.1.1 million deaths attributed to Shigella infections in developing countries, $60\%$ of deaths occur in the under-five age group. Travellers from developed to developing regions and soldiers serving under field conditions are also at an increased risk to develop shigellosis.
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대상 데이터
dysenteriae type 1, the first Shigella species isolated, was discovered by Kiyoshi Shiga in 1896 (Shiga, 1898). He was bom as the fifth child of Shin and Chiyo Sato on 5th February 1871 in Sendai, in northern Japan. His early years were difiEicuIt and due to economic hardship young Kiyoshi was raised in his maternal family and later adopted his mothers maiden name, Shiga, as his surname.
이론/모형
Antimicrobial susceptibility tests of all the confirmed Shigella isolates should be performed using an agar dif fusion technique method in accord with the National Committee for Clinical Laboratory Standards guidelines (NCCLS, 1997). The agar and broth dilution methods are also widely used (Ackerman and Dello, 1996) Newer methods like epsilometer strip method (E-test) is also a widely used method for accurate determination of mini mum inhibitoiy concentration (MIC) (Olssson-Liljequist, 1992).
성능/효과
Just two years after Shiga's complete description of S. dysenteriae type 1, Flexner found that parenteral injection of killed Shigella cultures in mice led to their death and on this basis concluded that disease was caused by “a toxic agent rather than infection per se." (Flexner, 1900).
참고문헌 (115)
Acheson, D.W.K., A. Donohue-Rolfe, and G.T. Keusch.1991. The family of Shiga and Shiga-like toxins. p. 415-433. In J E Alouf and J H Freer (ed.), Sourcebook of Bacterial Protein Toxins. Academic Press, New York
Ackerman, B.H and E.A. Dello Buono. 1996. In vitro testing of anti-biotics. Pharmacotherapy 16, 201-221
Angulo, F.J. and D.L. Swerdlow. 1995. Bacterial enteric infections in persons infected with human immunodeficiency virus. Clin. Inf. Dis. 21 Suppl. 1, S84-S93
Ashkenazi, S., G Dinari, A. Zevulunov, and M. Nitzan, 1987. Convulsions in childhood shigellosis. Clinical and laboratory features in 153 children. Am. J. Dis. Child. 141, 208-210
Ashkenazi, S, J. Amir, Y. Waisman, A. Rachmel, B.Z. Garty, Z. Samra, I. varsano, and M.M. Nitzan. 1993. A randomized, double-blind study compairing cefixime and trimethoprim-sulphamethoxazole in the treatment of childhood shigellosis. J. Paediatr. 123, 817-821
Ashkenazi, S., J.H. Passwell, E. Harlev, D. Miron, R. Dagan, N. Farzan, R. Ramon, E. Majady, D.A. Bryla, A.B. Karpas, J.B. Robbins, and R. Schneerson. The Israel Paediatric Shigella Study Group. 1999. Safety and immunogenecity of Shigella sonnei and Shigella flexneri 2a O specific polysaccharide conjugates in children. J. Infect. Dis. 179, 1565-1568
Basualdo, W., and A. Arbo. 2003. Randomized comparison of azithromycin versus cefixime for treatment of shigellosis in children. Pediatr: Infect. Dis. J. 22(4), 347-377
Batchelor, B.I, J.N. Kimari, and R.J. Brindle. 1996. Microbiology of HIV associated bacteraemia and diarrhoea in adults from Nairobi, Kenya. Epidemiol. Infect. 117, 139-144
Behring. E. and S. Kitasato. 1890. Ueber das Zustandkommen der Diphtherie-Immunitaet und der Tetanus-Immunitaet bei Thieren. Dtsch. Med. Wochenschr. 49,1-6
Bennish, M.L., M.A. Salam, R. Haider, and M. Barza 1990. Therapy for Shigellosis. II. Randomized,double-blind comparison of ciprofloxacin and ampicillin. J. Infect. Dis. 162, 711-716
Bennish, M.L., and B.J. Wojtyniak. 1991. Mortality due to shigellosis: community and hospital data. Rev. Infect. Dis. 13(Suppl. 4), S245-251
Bergey's manual of Determinative Bacteriology. 3rd ed. Williams & Wilkins Co., Baltimore, Maryland 1930: 357-363
Berlutti, E, M. Casalino, C. Zagaglia, P.A. Frandiani, P. Visca, and M. Nicoletti. 1998. Expression of the virulence plasmid-carried apyrase gene (apy) of enteroinvasive Escherichia coli and Shigella flexneri is under the control of H-NS and the VirF and VirB regulatory cascade. Infect. Immun. 66, 4957-4964
Bhattacharya, M.K., G.B. Nair, D. Sen, M. Paul, A. Debnath, A. Nag, D. Dutta, P. Dutta, S.C. Pal, and S.K. Bhattacharya. 1992. Efficacy of norfloxacin for shigellosis: A double-blind randomized clinical trial. J. Diarrhoeal. Dis. Res. 10, 146-150
Bhattacharya, S.K., P. Dutta, D. Dutta, M.K. Bhattacharya, D. Sen, M.R. Saha, G.B. Nair, P. Das, S.N. Sikdar, R. Bose, and S.C. Pal. 1987. Relative efficacy of trimethoprim-sulfamethoxazole and nalidixic acid for acute invasive diarrhoea. Antimicrob. Agent Chemother. 31,837
Bhattacharya, S.K., M.K. Bhattacharya, P. Dutta, D. Sen, R. Rasaily, A. Moitra, and S.C. Pal. 1991. Randomized clinical trial of norfloxacin for shigellosis. Am. J. Trop. Med. Hyg. 45, 683-687
Bhattacharya, S.K., M.K. Bhattacharya, D. Dutta, S. Dutta, M. Deb, A Deb, K.P. Das, H. Koley, and G.B. Nair. 1997. Double blind, randomized clinical trial for safety and efficacy of norfloxacin for shigellosis in children. Acta Paediatr. 86, 319-320
Bhattacharya, S.K., K. Sarkar, G.B. Nair, A.S.G. Faruque, and D.A. Sack. 2003 A regional alert of multidrug-resistant Shigella dysenteriae type 1 in South Asia. The Lancet. Inf. Dis. 3, 751
Black, R.E., K.H. Brown, S. Becker, A.R. Alim, and I. Huq. 1982. Longitudinal studies of infectious diseases and physical growth of children in rural Bangladesh. II. Incidence of diarrhoea and association with known pathogen. Am. J. Epidemiol. 115,315-324
Bose, R., J.N. Nashipuri, P.K. Sen, P. Dutta, S.K. Bhattacharya, D. Dutta, D. Sen, and M.K. Bhattacharya. 1984. Epidemic of dysentery in West Bengal: clinicians enigma. Lancet. 2, 1160
Butler, T., P. Speelman, I. Kabir, and J. Banwell. 1986. Colonic dysfunction during shigellosis. J. Infect. Dis. 154, 817-824
Chakrabarti, M.K., J. Bhattacharya, M.K. Bhattacharya, G.B. Nair, S.K. Bhattacharya, and D. Mahalanabis. 1999. Killed oral Shigella vaccine made from Shigella flexneri 2a protects against challenge in the rabbit model of shigellosis. Acta Paediatr. 88, 161-165
Cohen, D., M.S. Green, C. Block, R. Slepon, and Y. Lerman. 1992. Natural immunity to shigellosis in two groups with different previous risks of exposure to Shigella is only partly expressed by serum antibodies to lipopolysaccharide. J. Infect. Dis. 165, 785-787
Cohen, D., S. Ashkenazi, M.S. Green, M. Gdalevich, G. Robin, R. Slepon, M. Yavzori, N. Orr, C. Block, I. Ashkenazi, J. Shemer, D.N. Taylor, T.L. Hale, J.C. Sadoff, D. Pavliakova, R. Schneerson, and J.B. Robbins. 1997. Double-blind vaccine-controlled randomized efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults. Lancet. 349, 155-159
DuPont, H.L., R.B. Hornick, A.T. Dawkins, M.J. Snyder, and S.B. Formal. 1969. The response of man to virulent Shigella flexneri 2a. J. Infect. Dis. 119, 296-299
Du Pont, H.L., M.M. Levine, R.B. Hornick, and S.B Formal. 1989. Inoculum size in shigellosis and implications for expected mode of transmission J. Infect. Dis. 159, 1126-1128
DuPont, H.L., C.D. Ericsson, J.J. Mathewson, E. Palazzini, M.W. DuPont, Z.D. Jiang, A. Mosavi, and F.J. de la Cabada. 1998. Rifaximin, a nonabsorbed antimicrobial, in the therapy of travelers diarrhoea. Digestion. 59, 708-714
Ferreccio, C., V. Prado, A. Ojeda, M. Cayyazo, P. Abrego, L. Guers, and M.M. Levine. 1991.Epidemiologic patterns of acute diarrhoea and endemic Shigella infections in a poor periurban setting in Santiago, Chile. Am. J. Epidemiol. 134, 614-627
Finch, M., G. Rodey, D. Lawrence, and P. Blake. 1986. Epidemic Reiters syndrome following an outbreak of shigellosis. Eur. J. Epidemiol. 2, 26-30
Flexner, S. 1900. On the etiology of tropical dysentery. Bull. Johns Hopkins Hosp. 11, 231-242
Fontaine, A, J. Arondel, and P.J. Sansonetti. 1988. Role of Shiga toxin in the pathogenesis of bacillary dysentery studied using a tox mutant of Shigella dysenteriae type 1. Infect. Immun. 56, 3099-3109
Formal, S.B., R.M. Maenza, S. Austin, and E.H. LaBrec. 1967. Failure of parenteral vaccine to protect monkeys against experimental shigellosis. Proc. Soc. Exp. Biol. Med. 125, 347-349
Gangarosa, E.J., D.R. Perera, L.J. Mata, C.M. Morris, G Guzman, and L.B. Reller. 1970. Epidemic Shiga bacillus dysentery in Central America. II. Epidemiologic studies in 1969. J. Infect. Dis. 122, 181-190
Gotuzzo, E., R.A. Oberhelman, C. Maguina, S.J. Berry, A. Yi, M. Guzman, R. Ruiz, R. Leon-Barua, and B. Sack. 1989. Comparison of single-dose treatment with norfloxacin and standard 5-day treatment with trimethoprim-sulphamethoxazole for acute shigellosis in adults. Antimicrob. Agents Chemother. 33, 1101-1104
Guan, S. and N.K. Verma. 1998. Serotype conversion of a Shigella flexneri candidate vaccine strain via a novel site-specific chromosome-intigration system. FEMS Microbiol. Lett. 166, 79-87
Hartman, A.B. and M.M. Venkatesan. 1998. Construction of a stable attenuated Shigella sonnei Delta virG vaccine strain, WRSS1, and protective efficacy and immunogenecity in the guinea pig keratoconjunctivitis model. Infect. Immun. 66, 4572-4576
Hale, T.L. 1991. Genetic basis of virulence in Shigella species. Microbiol. Rev. 55, 206-224
Herrington, D.A., L. Van DeVerg, S.B. Formal, T.L. Hale, B.D. Tall, S.J. Cryz, E.C. Tramont, and M.M. Levine. 1990. Studies in volunteers to evaluate candidate Shigella vaccine: further experience with a bivalent Salmonella typhi-Shigella sonnei vaccine and protection conferred by previous Shigella sonnei disease. Vaccine 8, 353-357
Hong, M., M. Gleason, E.E. Wyckoff, and S.M. Payne. 1998. Identification of two Shigellaflexneri chromosomal loci involved in intercellular spreading. Infect. Immun. 66, 4700-4710
Keusch, G. T. 1998. The rediscovery of Shiga toxin and its role in clinical disease. Jpn. J. Med. Sci. Biol. 51(Suppl. I), S5-S22
Khan, W.A., C. Seas, U. Dhar, M.A. Salam, and M.L. Bennish. 1997. Treatment of shigellosis: V. Comparison ofazithromycin and ciprofloxacin. A double-blind randomized controlled trial. Ann. Intern. Med. 126(9),697-703
Kitasato, S. 1894. The bacillus of bubonic plague. Lancet. 2, 428-430
Koster, F., J. Levin, L. Walker, K.S. Tung, R.H. Gilman, M.M. Rahaman, M.M. Majid, S. Islam, and R.C. Williams. 1978. Hemolytic-uremic syndrome after shigellosis. Relation to endotoxemia and circulating immune complexes. N. Eng. J. Med. 298, 927-933
Kotloff, K.L., J.P. Nataro, G.A. Losonsky, S.S. Wasserman, T.L. Hale, D.N. Taylor, J.C. Sadoff, and M.M. Levine. 1995. A modified Shigella volunteer challenge model in which the inoculum is administered with bicarbonate buffer: clinical experience and implications for Shigella infectivity. Vaccine. 13, 1488-1494
Kotloff, K.L., J.P. Winickoff, B. Ivanoff, J.D. Clemens, D.L. Swerdlow, PJ. Sansonetti, G.K. Adak, and M.M. Levine. 1999. Global burden of Shigella infection:Implications for vaccine development and implementation of control strategies. Bull. WHO. 77, 651-666
Kotloff, K.L., F.R. Noriega, T. Samandari, M.B. Sztein, G.A. Losonsky, J.P. Nataro, W.D. Picking, E.M. Barry, and M.M. Levine. 2000. Shigellaflexneri 2a strain CVD 1207, with specific deletions in, virG, sen, set, and gua BA, is highly attenuated in humans. Infect. Immun. 68, 1034-1039
Kristjansson, M., B. Viner, and J.N. Maslow. 1994. Polymicrobial and recurrent bacteremia with in a patient with AIDS. Scand. J. Infect. Dis. 26, 411-416
Levine, O.S. and M.M. Levine. 1991. House flies (Musca domestica) as mechanical vectors of shigellosis. Rev. Infect. Dis. 13, 688-696
Mata, LJ., EJ. Gangarosa, A. Caceres, D.R. Perera, and M.L. Mejicanos. 1970. Epidemic Shiga bacillus dysentery in Central America. etiologic investigations in Guatemala, 1969. J. Infect. Dis. 122, 170-180
Mathan, V.I. and M.M. Mathan. 1991. Intestinal manifestations of invasive diarrhoeas and their diagnosis. Rev. Infect. Dis. 13 (Suppl 4), S311-313
McCormack, B.A., A.M. Siber, and A.T. Maurerelli. 1998. Requirement of the Shigella flexneri virulent plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epithelium. Infect. Immun. 66, 4237-4243
McKee, K.T. Jr, T.M Shields, P.R. Jenkins, J.M Zenilman, and G. E. Glass. 2000. Application of a geographic information system to the tracing and control of an outbreak of shigellosis. Clin. Inf. Dis. 31, 728-733
Mounier, J., V. Laurent, A. Hall, P. Fort, M.E. Carlier, P.J. Sansonetti, and C. Egile. 1999. Rho family Gl'Pases control entry of Shigella flexneri into epithelial cells but not intracellular motility. J. Cell Sci. 112, 2069-2080
Munshi, M.H., D.A. Sack, K. Halder, Z.U. Ahmed, M.M. Rahaman, and M.O. Murshed. 1987. Plasmid-mediated resistance to nalidixic acid in Shigella dysenteriae type 1. Lancet. 2,419-421
Murphy, G, L. Bodhidatta, P Echeverria, S. Tansuphaswadikul, C. W. Hoge, S. Imlarp, and K. Tamura. 1993. Ciprofloxacin and loperamide in the treatment of bacillary dysentery. Ann. Intern. Med. 118, 582
Nataro, J.P., J. Seriwatana, A. Fasano, D.R Maneval, L.D. Guers, F. Noriega, F. Dubovsky, M.M. Levine, and J.G Morris, Jr. 1995. Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains. Infect. Immun. 63, 4721-4728
National Committee for Clinical Laboratory Standards. 1997. Performance standard antimicrobial disk susceptibility tests: approved standards. M2-A6, 6th ed. National Committee for Clinical Laboratory Standards, Wayne, Pa
Nelson, J.D., H. Kusmiesz, and L.H. Jackson. 1976. Comparison of trimethoprim/ sulphamethoxazole and ampicillin therapy for shigellosis in ambulatory patients. J. Pediatr. 89, 491
Noriega, F.R., P.M. Liao, S.B. Formal, A. Fasano, and M.M. Levine. 1995. Prevalence of Shigella enterotoxin 1 among Shigella clinical isolates of diverse serotypes. J. Infect. Dis. 172, 1408-1410
Niyogi, S.K., U. Mitra, and P. Dutta. 2001. Changing pattern of serotypes and antimicrobial susceptibilities of Shigella species isolated from children in Calcutta, India. Jpn. J. Infect. Dis. 54, 121-122
Niyogi, S.K., M. Vargas, and J. Vila. 2004. Prevalence of the sat,set and sen genes among diverse serotypes of Shigella flexneri strains isolated from patients with acute diarrhoea. Clin. Microbiol. Infect. 10, 574-576
Pal, S.C. 1984. Epidemic bacillary dysentery in West Bengal. Lancet. 1, 1462
Panhotra, B.R., B. Desai, and P.L. Sharma, 1985. Nalidixic acid resistant Shigella dysenteriae type 1. Lancet. 1, 763
Pozsgay, V., C. Chiayung, L. Pannel, J. Wolfe, J.B. Robbins, and R. Schneerson. 1999. Protein conjugates of synthetic saccharides elicit higher levels of serum IgG lipopolysaccharide antibodies in mice than do those of the a-specific polysaccharide from Shigella dysenteriae type 1. Proc. Natl. Acad. Sci. USA 96, 5194-5197
Rahaman, M.M., M.M. Khan, K.M.S. Aziz, M.S. Islam, and A.K. Kibriya. 1975. An outbreak of dysentery caused by Shigella dysenteriae type 1 on a coral island in the bay of Bengal. J. Infect. Dis. 132, 15-
Robbins, J.B, C.Y. Chu, and R. Schneerson. 1992. Hypothesis for vaccine development: Protective immunity to enteric diseases caused by non-typhoidal Salmonella and Shigellae may be conferred by serum IgG antibodies to the O-specific polysaccharide of their lipopolysaccharides. Clin. Infect. Dis. 15,346-361
Robbins, J.B, R. Schneerson, and S.C. Szu. 1995. Perspective: hypothesis: serum IgG antibody is sufficient to confer protection against infectious disease by inactivating the inoculum. J. Infect. Dis. 171, 1378-1398
Ross, S., G. Controno, and W. Khan. 1972. Resistance of shigellae to ampicillin and other antibiotic. J. Am. Med. Assoc. 221, 45
Salam, M.A. and M.L. Bennish. 1988. Therapy for shigellosis I randomized double-blind trial of nalidixic acid in childhood shigellosis. J Pediatr. 113, 901-907
Salam, M.A. and M.L. Bennish. 1991. Antimicrobial therapy for shigellosis. Rev. Infect. Dis. 13(Suppl 4), S332-S341
Salam, M.A., C. Seas, W.A. Khan, and M.L. Bennish. 1995. Treatment of shigellosis: IV cefixime is ineffective in shigellosis in adults. Ann. Intern. Med. 123(7), 505-508
Sansonetti, P.J. and J. Arondel. 1989. Construction and evaluation of a double mutant of Shigella flexneri as a candidate for oral vaccination against shigellosis. Vaccine 7, 443-450
Sarkar, K., S. Ghosh, S.K. Niyogi, and S.K. Bhattacharya. 2003. Shigella dysenteriae type 1 with reduced susceptibility to fluoroquinolone. Lancet. 361, 785
Schuch, R. and A.T. Maurelli. 1999. The mxi-Spa type III secretory pathway of Shigella flexneri requires an outer membrane lipoprotein MxiM, for invasion translocation. Infect. Immun. 67, 1982-1991
Sen, D., P. Dutta, B.C. Deb, and S.C. Pal. 1988. Nalidixic acid resistant Shigella dysenteriae type 1 in Eastern India. Lancet. 2, 911
Shears, P. 1996. Shigella infection. Ann. Trop. Med. Parasitol. 90, 105-114
Shiga, K. 1898. Ueber den Erreger der Dysenterie in Japan. Vorlaufige Mitteilung Zentralbal Bakteriol Microbiol Hyg. 23, 599-600
Shiga, K. 1898. Ueber den Dysenterie bacillus (Bacillus dysenteriae), Zentralbl Bakteriol Parasitenkd Abt I Org. 24, 817-824
Shiga, K. 1906. Obsevation on the epidemiology of dysentery in Japan. Philippine J. of Sci. 1, 485-500
Shiga, K. and K. Kanwa. 1950. Tokyo: Nihon Iji Shimpo Shuppanbu
Shiga, K. 1936. The trend of prevention, therapy, and epidemiology of dysentery since the discovery of its causative organisms. N. Engl. J. Med. 215, 1205-1211
Sieper, J., J. Braun, P. Wu, R. Hauer, and S. Laitko. 1993. The possible role of Shigella in sporadic enteric reactive arthritis. Br. J. Rheumatol. 32, 582-585
Struelens, M.J., D. Patte, I. Kabir, A. Salam, S.K. Nath, and T. Butler. 1985. Shigella septicemia: prevalence, presentation, risk factors, and outcome. J. Infect. Dis. 152, 784-790
Sur, D., S.K. Niyogi, S. Sur, K.K. Datta, Y. Takeda, G.B. Nair, and S.K. Bhattacharya 2003. Multi-drug resistant Shigelaa dysenteriae type 1: Forerunners of a new epidemic strain in eastern India? Emerg. Inf. Dis. 9(3), 404-405
Taylor, D., P. Echeverria, T. Pal, O. Sethabutr, S. Saiborisuth, S. Sricharmorn, B. Rowe, and J. Cross. 1986. The role of Shigella spp., enteroinvasive Escherichia coli and other enteropathogens as cause of childhood dysentery in Thailand. J. Infect. Dis. 153, 1132-1138
Vargas, M., J. Gascon, M.T. Jimenez, De Anta., and J. Vila. 1999. Prevalence of Shigella enterotoxins 1 and 2 among Shigella strains isolated from patients with travelers diarrhoea. J. Clin. Microbiol. 37, 3608-3611
Varsano, I., T. Elditz-marcus, M. Nussinovch, and I. Elian. 1991. Comparative efficacy of ceftriaxone and ampicillin for treatment of severe shigellosis in children. J. Pediatr. 118, 627-632
Way, S.S., A.C. Borczuk, R. Dominit, and M.B. Goldberg. 1998. An essential role for gamma interferon in inate resistance to Shigella flexneri infection. Infect. Immun. 66, 1342-1348
World Health Organization. 1987. Manual for the investigation of acute enteric infections, programme for control of diarrhoeal diseases. Geneva CDD/83.3. Rev. 1
World Health Organization. 1995. The treatment of diarrhoea. A manual for physicians and other senior health workers. Geneva, Switzerland (WHO/CDR/95.3)
World Health Organization. 1997. New strategies for accelerating Shigella vaccine development. Weekly Epidemiol Record. 72, 73-80
World Health Organization. 2001. Antimicrobial resistance in shigellosis, cholera and campylobacteriosis. WHO/CDS/CSR/ DRS/2001.8. World Health Organization, Geneva, Switzerland
Yavzori, M., D. Cohen, and N. Orr. 2002. Prevalence of the genes for shigella enterotoxin 1 and 2 among clinical isolates of shigella in Israel. Epidemiol. Infect. 128, 533-535
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